CoReCG

Evidence Information

Pubmed ID	Year	Sample Information	Techniques	Mechanism	Fold Change	Remark
22065111	2012	Cell line : DLD1, Caco Source : ATCC and First Afiliated hospital of Xi'an jianotong university. Sample Type : CRC Tumor and normal tissue No. of Sample : 83 CRC and 54 normal tissue Stage : TNM Stage I-IV.	Immunohistochemistry, western blotting, ELISA	Up-regulation	-	PTN could serve as a prognostic factor for this cancer. Considering that PTN shows very limited expression in normal tissue, it may represent an attractive new target for CRC therapy.

Gene Details

NC_000007.13 (136912088..137028606, complement)
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Gene Type	protein coding
Gene Family	Endogenous ligands
Description	-
Chromosome	7
Location	7q33
Start	136912088
End	137028606
Strand	-
Gene Sequence	Download   Select all
Length	116519
OMIM ID	162095
HGNC ID	HGNC:9630
Unigene ID	Hs.371249
Ensembl ID	ENSG00000105894
PharmGKB ID	PA33974

mRNA Information

mRNA ID	?NM_002825.5
Exon	join(1..422,88887..89002,90224..90397,92470..92631, 115789..116520)
mRNA Sequence	Download   Select all
Length	1606

CDS Information

   

Location	424..927
CDS Sequence	Download   Select all
CCDS ID	CCDS5844.1

Protein Information

      

Protein ID	NP_002816.1
Protein Name	pleiotrophin
Molecular Wt. (Da)	32597
Protein Sequence	Download   Select all
Length	168
Uniprot ID	O14936
Ensembl Protein ID	ENSP00000367400

Post-translational Modification Information (Source : HPRD)

Residue	Type	site
C	Disulfide Bridge	109;141
C	Disulfide Bridge	47;76
C	Disulfide Bridge	55;85
C	Disulfide Bridge	62;89
C	Disulfide Bridge	99;131

Enzyme Information

No matching records could be found.

PPi Information

(Click to view network : Source STRING)      View   

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       

Interactant Gene ID (Source: HPRD)	Gene Symbol	HPRD ID	Ref Seq ID	Technique	References
60	ACTB	32	NP_001092.1	in vivo	9739080
238	ALK	104	NP_004295.2	in vitro;in vivo	11278720
832	CAPZB	11872	NP_004921.1	yeast 2-hybrid	16169070
3910	LAMA4	2532	NP_001098676.1	yeast 2-hybrid	16169070
5034	P4HB	7181	NP_000909.2	yeast 2-hybrid	16169070
5515	PPP2CA	8912	NP_002706.1	yeast 2-hybrid	16169070
5708	PSMD2	5870	NP_002799.3	yeast 2-hybrid	16169070
5717	PSMD11	5119	NP_002806.2	yeast 2-hybrid	16169070
5802	PTPRS	3344	NP_002841.3	yeast 2-hybrid	16169070
6016	RIT1	10195	NP_008843.1	yeast 2-hybrid	16169070
6176	RPLP1	1611	NP_000994.1	yeast 2-hybrid	16169070
6303	SAT1	2431	NP_002961.1	yeast 2-hybrid	16169070
6449	SGTA	4568	NP_003012.1	yeast 2-hybrid	16169070
6745	SSR1	2924	NP_003135.2	yeast 2-hybrid	16169070
6866	TAC3	8877	NP_001006668.1	yeast 2-hybrid	16169070
7159	TP53BP2	11803	NP_001026855.2	yeast 2-hybrid	16169070
8195	MKKS	5356	NP_061336.1	yeast 2-hybrid	16169070
8614	STC2	4717	NP_003705.1	yeast 2-hybrid	16169070
8665	EIF3F	4887	NP_003745.1	yeast 2-hybrid	16169070
9238	TBRG4	10263	NP_004740.2	yeast 2-hybrid	16169070
9587	MAD2L1BP	10065	NP_001003690.1	yeast 2-hybrid	16169070
9627	SNCAIP	4804	NP_005451.2	yeast 2-hybrid	16169070
9804	TOMM20	3507	NP_055580.1	yeast 2-hybrid	16169070
9905	SGSM2	15284	NP_055668.2	yeast 2-hybrid	16169070
9913	SUPT7L	18115	NP_055675.1	yeast 2-hybrid	16169070
10190	TXNDC9	15592	NP_005774.2	yeast 2-hybrid	16169070
10249	GLYAT	7603	NP_964011.2	yeast 2-hybrid	16169070
10399	GNB2L1	1503	NP_006089.1	yeast 2-hybrid	16169070
10406	WFDC2	11684	NP_006094.3	yeast 2-hybrid	16169070
10425	ARIH2	9286	NP_006312.1	yeast 2-hybrid	16169070
10927	SPIN1	18096	NP_006708.2	yeast 2-hybrid	16169070
11243	PMF1	11441	NP_009152.2	yeast 2-hybrid	16169070
11266	DUSP12	5323	NP_009171.1	yeast 2-hybrid	16169070
23654	PLXNB2	5050	NP_036533.2	yeast 2-hybrid	16169070
26292	MYCBP	8406	NP_036465.2	yeast 2-hybrid	16169070
50618	ITSN2	9193	NP_006268.2	yeast 2-hybrid	16169070
51019	CCDC53	13031	NP_057137.1	yeast 2-hybrid	16169070
51236	C8orf30A	17423	NP_057542.2	yeast 2-hybrid	16169070
51631	LUC7L2	17456	NP_057103.2	yeast 2-hybrid	16169070
51726	DNAJB11	7485	NP_057390.1	yeast 2-hybrid	16169070
54544	CRCT1	16635	NP_061933.1	yeast 2-hybrid	16169070
54622	ARL15	12471	NP_061960.1	yeast 2-hybrid	16169070
54810	GIPC2	17040	NP_060125.4	yeast 2-hybrid	16169070
55147	RBM23	15227	NP_001070819.1	yeast 2-hybrid	16169070
55186	SLC25A36	7688	NP_001098117.1	yeast 2-hybrid	16169070
55643	BTBD2	12252	NP_060267.2	yeast 2-hybrid	16169070
55755	CDK5RAP2	9740	NP_060719.4	yeast 2-hybrid	16169070
56647	BCCIP	16542	NP_057651.1	yeast 2-hybrid	16169070
56893	UBQLN4	5670	NP_064516.2	yeast 2-hybrid	1   616   907   016   713   560
57050	UTP3	18016	NP_065101.1	yeast 2-hybrid	16169070
60489	APOBEC3G	6172	NP_068594.1	yeast 2-hybrid	16169070
78987	CRELD1	6206	NP_001026887.1	yeast 2-hybrid	16169070
79101	TAF1D	14679	NP_077021.1	yeast 2-hybrid	16169070
79663	HSPBAP1	12197	NP_078886.2	yeast 2-hybrid	16169070
79886	C9orf82	12981	NP_079104.3	yeast 2-hybrid	16169070
84141	FAM176A	7827	NP_115557.1	yeast 2-hybrid	16169070
266812	NAP1L5	17626	NP_715638.1	yeast 2-hybrid	16169070

Pathway Information

No matching records could be found.

Structure Information

No matching records could be found.

Domain Information

ID	Location	Description
smart00193	47-131	PTN
cl02505	47-131	PTN_MK_N superfamily
pfam01091	96-151	PTN_MK_C
cl03092	96-151	PTN_MK_C superfamily
pfam05196	45-95	PTN_MK_N

Ontology Information

   

HPRD ID	4469
Molecular Class	Cytokine
Molecular Function	Transcription factor activity (GO:0003700)
Biological Process	Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219)

SNP Information

View SNP Geneview Report