Search results:


General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
FANCM 57697 Fanconi anemia, complementation group M  14FAAP250 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
23585368   2013Cell line : -

Source : -

Sample Type : CRC tumor and normal tissue

No. of Sample : 50

Stage : -

-Mutation-Somatic mutations in the corresponding genes in the CRCs of the patients harboring the germline lesions and found biallelic inactivation of FANCM, LAMB4, PTCHD3, LAMC3, and TREX2, potentially implicating these genes as tumor suppressors.


Gene Details



NC_000014.8 (45605136..45670093)

View Larger Image
   
Gene Type protein coding
Gene Family Fanconi anemia, complementation groups
Description The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group M. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]  
Chromosome 14
Location 14q21.3
Start 45605136  
End 45670093  
Strand +  
Gene Sequence

   Download   Select all

Length 64958  
OMIM ID 609644   
HGNC ID HGNC:23168   
Unigene ID Hs.509229   
Ensembl ID -   
PharmGKB ID PA134943156   

mRNA Information


mRNA ID ?NM_001308133.1
Exon  
mRNA Sequence

   Download   Select all

Length  



CDS Information


   
Location
CDS Sequence

   Download   Select all

CCDS ID CCDS32070.1



Protein Information


      
Protein IDNP_001295062.1
Protein NameFanconi anemia, complementation group M
Molecular Wt. (Da)0
Protein Sequence

   Download   Select all

Length 2048  
Uniprot IDQ96GC9
Ensembl Protein ID ENSP00000262291  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation1437
SPhosphorylation997
TPhosphorylation470
TPhosphorylation470

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

No matching records from HPRD source could be found.

Pathway Information


      
Pathway Name Pathway ID
Fanconi anemia pathway hsa03460


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd12091298-413  FANCM_ID
cl17041298-413  helicase_insert_domain superfamily
cd00079439-589  HELICc
cl21455439-589  P-loop_NTPase superfamily
cd00046106-248  DEXDc
cl21455106-248  P-loop_NTPase superfamily
pfam00271521-579  Helicase_C
smart00490490-580  HELICc
pfam00270106-255  DEAD
pfam027321828-1948  ERCC4
cl105941828-1948  ERCC4 superfamily
smart008911819-1899  ERCC4
pfam0485188-248  ResIII
cd09639475-594  Cas3_I
pfam094441508-1589  MRC1
cl096841508-1589  MRC1 superfamily
COG111183-617  MPH1
PRK1376692-612  PRK13766
COG19481842-2038  MUS81
smart0048790-264  DEXDc
COG106192-584  SSL2
PRK137661814-2026  PRK13766
COG0513450-596  SrmB
COG1204106-247  BRR2
TIGR005961832-2027  rad1
PRK11192472-579  PRK11192
PRK01297478-579  PRK01297
COG1201523-595  Lhr
COG1205106-320  YprA
PRK11634480-597  PRK11634
COG4098442-580  comFA
COG0556524-703  UvrB
TIGR00580488-582  mfd
PTZ00424521-579  PTZ00424
PRK00254106-250  PRK00254
TIGR01587475-612  cas3_core
PRK11776522-579  PRK11776
TIGR00631524-703  uvrb
PRK04837510-579  PRK04837
COG1200488-579  RecG
PTZ00110522-579  PTZ00110
PRK13767547-586  PRK13767
COG1197487-583  Mfd
COG1203438-595  Cas3
COG4581108-247  Dob10
PRK10590532-579  PRK10590
COG1205456-588  YprA


Ontology Information


   
HPRD ID6874
Molecular ClassATPase
Molecular FunctionTranscription regulator activity (GO:0030528)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO