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General Information
- Evidence
- Gene
- mRNA
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- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 18795671 | 2008 | Cell line : - Source : - Sample Type : CRC tumor No. of Sample : 15 colonoscopic biopsy and 25 colectomy colorectal cancer samples, 12 hyperplastic colon polyps, and 18 tubular and 19 villous adenoma cases Stage : - | Immunohistochemistry | Down-regulation | - | Decrease of supranuclear granular staining with Bak and Bcl-xl, and survivin expression, can be used as indicators of poor prognosis. |
| 24939147 | 2014 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | Immunohistochemistry | Down-regulation | - | Association was found between Bak protein in primary tumor and in adjacent metastatic lymph nodes. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form oligomers or heterodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein localizes to mitochondria, and functions to induce apoptosis. It interacts with and accelerates the opening of the mitochondrial voltage-dependent anion channel, which leads to a loss in membrane potential and the release of cytochrome c. This protein also interacts with the tumor suppressor P53 after exposure to cell stress. [provided by RefSeq, Jul 2008] |
| Chromosome | 6 |
| Location | 6p21.31 |
| Start | 33540323 |
| End | 33548072 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 7750 |
| OMIM ID | 600516 |
| HGNC ID | HGNC:949 |
| Unigene ID | Hs.485139 |
| Ensembl ID | ENSG00000030110 |
| PharmGKB ID | PA25253 |
mRNA Information
| mRNA ID | NM_001188.3 |
|---|---|
| Exon | join(7..275,2665..2765,4372..4507,4859..5002,6086..6266, 6393..7754) | mRNA Sequence | Download Select all |
| Length | 2203 |
Protein Information
| Protein ID | NP_001179.1 |
|---|---|
| Protein Name | BCL2-antagonist/killer 1 |
| Molecular Wt. (Da) | 23278 |
| Protein Sequence | Download Select all |
| Length | 211 |
| Uniprot ID | P03956 |
| Ensembl Protein ID | ENSP00000322788 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 581 | BAX | 2498 | NP_004315.1 | in vivo | 11571294 |
| 596 | BCL2 | 1045 | NP_000624.2 | in vitro;in vivo | 11 728 179 946 338 100 000 000 |
| 598 | BCL2L1 | 2497 | NP_612815.1 | in vitro;in vivo | 11 175 750 159 016 700 000 000 000 000 000 |
| 2081 | ERN1 | 4943 | NP_001424.3 | in vitro;in vivo | 16645094 |
| 3329 | HSPD1 | 318 | NP_002147.2 | in vitro;in vivo | 12070120 |
| 7157 | TP53 | 1859 | NP_000537.3 | in vitro;in vivo | 15077116 |
| 7416 | VDAC1 | 5137 | NP_003365.1 | in vitro | 106 391 219 843 949 |
| 7417 | VDAC2 | 1904 | AAA60144.1 | in vitro;in vivo | 12881569 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| MicroRNAs in cancer | hsa05206 |
| Protein processing in endoplasmic reticulum | hsa04141 |
| Viral carcinogenesis | hsa05203 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd06845 | 29-183 | Bcl-2_like |
| cl02575 | 29-183 | Bcl-2_like superfamily |
| pfam00452 | 78-177 | Bcl-2 |
| smart00337 | 78-177 | BCL |
| TIGR00865 | 49-183 | bcl-2 |
Ontology Information
| HPRD ID | 386 |
|---|---|
| Molecular Class | Adapter molecule |
| Molecular Function | Metallopeptidase activity (GO:0008237) |
| Biological Process | Protein metabolism (GO:0019538) |
Drug Information
No matching records could be found.