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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| PTPRO | 5800 | protein tyrosine phosphatase, receptor type, O | 12 | PTPU2, GLEPP1, PTP-U2, PTP-oc, NPHS6 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 25301722 | 2014 | Cell line : HCT15, HCT116, SW480, CACO2, LOVO, LIM1215, DIFI, DKO4, COLO205, HT29, DLD1, HKE3, HCA-46, HKH2 Source : ATCC Sample Type : - No. of Sample : - Stage : - | Immunoblotting and immunoprecipitation,Collaborative enzyme enhance reactive Immuno Assay ),In vitro substrate trapping assay,In vitro dephosphorylation assay | Down-regulation | - | PTPRO contribution in negative regulation of SRC/EGFR signaling and also suggest that tumors with low PTPRO expression may be therapeutically targetable by anti-SRC therapies. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Protein tyrosine phosphatases / Class I Cys-based PTPs : Transmembrane receptor-like, "Fibronectin type III domain containing" |
| Description | This gene encodes a member of the R3 subtype family of receptor-type protein tyrosine phosphatases. These proteins are localized to the apical surface of polarized cells and may have tissue-specific functions through activation of Src family kinases. This gene contains two distinct promoters, and alternatively spliced transcript variants encoding multiple isoforms have been observed. The encoded proteins may have multiple isoform-specific and tissue-specific functions, including the regulation of osteoclast production and activity, inhibition of cell proliferation and facilitation of apoptosis. This gene is a candidate tumor suppressor, and decreased expression of this gene has been observed in several types of cancer. [provided by RefSeq, May 2011] |
| Chromosome | 12 |
| Location | 12p13-p12 |
| Start | 15475191 |
| End | 15751265 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 276075 |
| OMIM ID | 600579 |
| HGNC ID | HGNC:9678 |
| Unigene ID | Hs.160871 |
| Ensembl ID | ENSG00000151490 |
| PharmGKB ID | PA34023 |
mRNA Information
| mRNA ID | ?NM_002848.3 |
|---|---|
| Exon | join(1..545,161718..161991,174989..175147,177186..177338, 179364..179807,181652..181813,186315..186511, 193242..193362,194507..194700,197945..198056, 202558..202709,203886..204006,224313..224452, 226838..226970,229295..229415,235199..235267, 237937..238020,243337..243372,247161..247242, 256597..256687,257783..257859,258441..258575, 259423..259545,264641..264795,267199..267334, 272681..272801,273834..276075) | mRNA Sequence | Download Select all |
| Length | 6379 |
Protein Information
| Protein ID | NP_002839.1 |
|---|---|
| Protein Name | protein tyrosine phosphatase, receptor type, O |
| Molecular Wt. (Da) | 215323 |
| Protein Sequence | Download Select all |
| Length | 1216 |
| Uniprot ID | P42330 |
| Ensembl Protein ID | ENSP00000369927 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 3815 | KIT | 1287 | NP_000213.1 | in vivo | 10397721 |
| 5292 | PIM1 | 1292 | NP_002639.1 | in vitro;in vivo | 11368509 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00047 | 965-1193 | PTPc |
| cl21483 | 965-1193 | PTPc superfamily |
| cd00063 | 434-526 | FN3 |
| cl21522 | 434-526 | FN3 superfamily |
| cd00063 | 530-630 | FN3 |
| cl21522 | 530-630 | FN3 superfamily |
| cd00063 | 723-805 | FN3 |
| cl21522 | 723-805 | FN3 superfamily |
| smart00404 | 1092-1192 | PTPc_motif |
| smart00012 | 1092-1192 | PTPc_DSPc |
| pfam00041 | 725-805 | fn3 |
| pfam00041 | 435-521 | fn3 |
| smart00060 | 723-802 | FN3 |
| pfam14566 | 1101-1149 | PTPlike_phytase |
| smart00060 | 530-612 | FN3 |
| smart00195 | 1094-1148 | DSPc |
| PTZ00242 | 1084-1149 | PTZ00242 |
| smart00060 | 436-510 | FN3 |
| pfam00782 | 1083-1148 | DSPc |
| smart00194 | 937-1192 | PTPc |
| pfam00102 | 962-1193 | Y_phosphatase |
| COG5599 | 960-1193 | COG5599 |
| PHA02742 | 962-1192 | PHA02742 |
| PHA02738 | 962-1194 | PHA02738 |
| PHA02746 | 960-1193 | PHA02746 |
| PHA02747 | 960-1189 | PHA02747 |
| PHA02740 | 962-1209 | PHA02740 |
| COG2453 | 1080-1192 | CDC14 |
Ontology Information
| HPRD ID | 4669 |
|---|---|
| Molecular Class | Receptor tyrosine phosphatase |
| Molecular Function | Receptor signaling complex scaffold activity (GO:0030159) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.