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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
PTPRS 5802 protein tyrosine phosphatase, receptor type, S  19- 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
23096495   2013Cell line : -

Source : -

Sample Type : CRC Tumor and normal tissue

No. of Sample : 131

Stage : -

methyl specific PCR,microarrayMethylation-PTPR family has an important role in the etiology of CRC.


Gene Details



NC_000019.9 (5205514..5340814, complement)

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Gene Type protein coding
Gene Family Protein tyrosine phosphatases / Class I Cys-based PTPs : Transmembrane receptor-like, "Immunoglobulin superfamily / I-set domain containing", "Fibronectin type III domain containing"
Description The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this protein is composed of multiple Ig-like and fibronectin type III-like domains. Studies of the similar gene in mice suggested that this PTP may be involved in cell-cell interaction, primary axonogenesis, and axon guidance during embryogenesis. This PTP has been also implicated in the molecular control of adult nerve repair. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]  
Chromosome 19
Location 19p13.3
Start 5205514  
End 5340814  
Strand -  
Gene Sequence

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Length 135301  
OMIM ID 601576   
HGNC ID HGNC:9681   
Unigene ID Hs.744928   
Ensembl ID -   
PharmGKB ID PA34026   

mRNA Information


mRNA ID ?NM_002850.3
Exon join(31..140,54570..54754,66460..66605,67221..67362, 75608..75796,82677..82787,94759..95028,96322..96903, 100472..100605,101741..101885,109189..109494, 111120..111313,111462..111488,114960..115077, 117507..118115,118584..118681,119551..119804, 120451..120544,120650..120865,121337..121494, 122006..122017,122272..122384,124037..124084, 125209..125306,125392..125515,126068..126243, 126324..126443,128313..128467,128554..128839, 129036..129214,129999..130125,130210..130335, 132413..132567,132747..132882,133962..135301)  
mRNA Sequence

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Length 7283  



CDS Information


   
Location 205..6012
CDS Sequence

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CCDS ID CCDS12139.1



Protein Information


      
Protein IDNP_002841.3
Protein Nameprotein tyrosine phosphatase, receptor type, S
Molecular Wt. (Da)30082
Protein Sequence

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Length 1948  
Uniprot IDP49757
Ensembl Protein ID ENSP00000347169  



Post-translational Modification Information (Source : HPRD)


Residue Type site
NGlycosylation733
NGlycosylation720
SPhosphorylation396
SPhosphorylation383
SPhosphorylation387
SPhosphorylation383

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                                                                                                  
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
1937EEF1G11745NP_001395.1yeast 2-hybrid16169070   
1956EGFR579NP_005219.2in vivo10435588   
5786PTPRA1476NP_002827.1in vitro;in vivo10777529   
5791PTPRE2956NP_006495.1in vivo12376545   
5797PTPRM1479NP_001098714.1in vivo12376545   
9094UNC1194927NP_005139.1yeast 2-hybrid16169070   
9638FEZ19212NP_005094.1yeast 2-hybrid16169070   
9869SETDB16828NP_001138887.1yeast 2-hybrid16169070   
10524KAT53245NP_874369.1in vitro;yeast 2-hybrid16169070   
10813UTP14A6712NP_006640.2yeast 2-hybrid16169070   
11021RAB355010NP_006852.1yeast 2-hybrid16169070   
25843MOBKL310165NP_056202.2yeast 2-hybrid16169070   
57562KIAA137717212NP_065853.2yeast 2-hybrid16169070   
197131UBR19342NP_777576.1yeast 2-hybrid16169070   


Pathway Information


No matching records could be found.

Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd000471418-1647  PTPc
cl214831418-1647  PTPc superfamily
cd000471708-1938  PTPc
cl214831708-1938  PTPc superfamily
cd05739259-327  Ig3_RPTP_IIa_LAR_like
cl11960259-327  Ig superfamily
cd05738152-235  Ig2_RPTP_IIa_LAR_like
cl11960152-235  Ig superfamily
cd00063332-421  FN3
cl21522332-421  FN3 superfamily
cd00063525-613  FN3
cl21522525-613  FN3 superfamily
cd00063428-520  FN3
cl21522428-520  FN3 superfamily
cd00063621-715  FN3
cl21522621-715  FN3 superfamily
cd00063723-828  FN3
cl21522723-828  FN3 superfamily
cd00063932-1029  FN3
cl21522932-1029  FN3 superfamily
cd00063838-920  FN3
cl21522838-920  FN3 superfamily
cd000631037-1097  FN3
cl215221037-1097  FN3 superfamily
smart000121835-1938  PTPc_DSPc
smart004041835-1938  PTPc_motif
smart004041546-1647  PTPc_motif
smart000121546-1647  PTPc_DSPc
pfam00041334-414  fn3
smart00060525-603  FN3
pfam00041621-708  fn3
pfam00041526-606  fn3
smart00060332-411  FN3
smart00060428-510  FN3
pfam00041428-513  fn3
cd00096152-228  Ig
cd05724151-234  Ig2_Robo
cd0769332-120  Ig1_Robo
cl1196032-120  Ig superfamily
smart00060621-705  FN3
pfam00041932-1022  fn3
cd0009650-121  Ig
cd0572550-124  Ig3_Robo
pfam00041723-821  fn3
cd0572438-124  Ig2_Robo
cd0574654-123  Ig4_Peroxidasin
smart00060723-818  FN3
pfam13895135-234  Ig_2
cd0496832-124  Ig3_Contactin_like
cd0572234-124  Ig1_Neogenin
cd05746156-228  Ig4_Peroxidasin
smart00060932-1019  FN3
cd00096262-325  Ig
cd0572854-124  Ig4_Contactin-2-like
pfam00041838-916  fn3
cd05748159-223  Ig_Titin_like
cd07693135-234  Ig1_Robo
cd0497847-125  Ig4_L1-NrCAM_like
cd05729156-223  Ig2_FGFR_like
cd0585132-124  Ig3_Contactin-1
cd05728156-234  Ig4_Contactin-2-like
smart00060836-914  FN3
cd05731156-223  Ig3_L1-CAM_like
cd0576350-125  Ig_1
cd05728255-328  Ig4_Contactin-2-like
cd0574547-124  Ig3_Peroxidasin
cd05856156-223  Ig2_FGFRL1-like
smart000601036-1097  FN3
cd0574732-123  Ig5_Titin_like
cd04968151-223  Ig3_Contactin_like
pfam13927244-315  Ig_3
cd05857142-223  Ig2_FGFR
cd05733156-228  Ig6_L1-CAM_like
cd05729258-328  Ig2_FGFR_like
cd04978151-234  Ig4_L1-NrCAM_like
cd0572352-124  Ig4_Neogenin
cd05737141-223  Ig_Myomesin_like_C
cd05894159-235  Ig_C5_MyBP-C
cd05730151-223  Ig3_NCAM-1_like
pfam145661556-1606  PTPlike_phytase
cd05726150-223  Ig4_Robo
cd05732152-224  Ig5_NCAM-1_like
cd0573053-122  Ig3_NCAM-1_like
cd05725266-328  Ig3_Robo
cd05745150-223  Ig3_Peroxidasin
cd05891141-223  Ig_M-protein_C
cd04972250-328  Ig_TrkABC_d4
cd05736263-329  Ig2_Follistatin_like
cd05747141-223  Ig5_Titin_like
cd05732257-319  Ig5_NCAM-1_like
pfam000411037-1097  fn3
cd05743151-229  Ig_Perlecan_D2_like
cd0576547-124  Ig_3
pfam09294526-599  Interfer-bind
cd05736152-224  Ig2_Follistatin_like
cd05764150-223  Ig_2
pfam00047259-313  ig
cd05848154-232  Ig1_Contactin-5
cd05763152-234  Ig_1
pfam0004747-109  ig
pfam1392732-111  Ig_3
cd0585847-125  Ig3_FGFR-2
cd0573650-114  Ig2_Follistatin_like
cd0573154-121  Ig3_L1-CAM_like
cd0572952-124  Ig2_FGFR_like
cd05763266-328  Ig_1
cd05750157-223  Ig_Pro_neuregulin
cd05856259-328  Ig2_FGFRL1-like
cd05857258-328  Ig2_FGFR
cd05743259-320  Ig_Perlecan_D2_like
cd0584833-116  Ig1_Contactin-5
cd05869146-224  Ig5_NCAM-1
cd05851150-235  Ig3_Contactin-1
cd0496947-124  Ig5_Contactin_like
cd0576447-124  Ig_2
cd05764259-329  Ig_2
pfam1389547-117  Ig_2
cd05749247-327  Ig2_Tyro3_like
cd04968259-328  Ig3_Contactin_like
cd04978259-328  Ig4_L1-NrCAM_like
cd05725152-223  Ig3_Robo
pfam13927135-220  Ig_3
cd05723266-328  Ig4_Neogenin
cd05870259-318  Ig5_NCAM-2
cd05759152-222  Ig2_KIRREL3-like
cd04969259-328  Ig5_Contactin_like
cd05870152-223  Ig5_NCAM-2
cd0497246-124  Ig_TrkABC_d4
cd0585654-124  Ig2_FGFRL1-like
cd001271837-1916  DSPc
pfam00047151-218  ig
cd0496733-116  Ig1_Contactin
cd0577344-115  Ig8_hNephrin_like
cd04970152-235  Ig6_Contactin_like
cd0572647-124  Ig4_Robo
cd04972140-224  Ig_TrkABC_d4
cd05765151-224  Ig_3
cd05876153-223  Ig3_L1-CAM
cd04967153-231  Ig1_Contactin
cd05867151-223  Ig4_L1-CAM_like
pfam09294621-692  Interfer-bind
pfam13895253-328  Ig_2
cd05745259-328  Ig3_Peroxidasin
smart001951569-1643  DSPc
smart001941392-1647  PTPc
smart001941679-1938  PTPc
pfam0767933-124  I-set
smart00408150-223  IGc2
smart00410251-328  IG_like
pfam001021416-1647  Y_phosphatase
pfam001021705-1938  Y_phosphatase
COG55991680-1947  COG5599
COG55991382-1647  COG5599
PHA027381416-1645  PHA02738
PHA027471703-1931  PHA02747
PHA027461407-1645  PHA02746
PHA027471407-1642  PHA02747
PHA027381705-1944  PHA02738
PHA027421705-1939  PHA02742
PHA027421416-1647  PHA02742
PHA027461675-1935  PHA02746
PHA027401700-1940  PHA02740
PHA027401389-1645  PHA02740
smart00410141-234  IG_like
smart00409141-234  IG
smart0041039-124  IG_like
smart0040939-124  IG
smart00409251-328  IG
pfam07679151-223  I-set
COG24531493-1646  CDC14
pfam07679245-328  I-set
smart0040846-114  IGc2
smart00408258-318  IGc2
PHA0278564-315  PHA02785
COG24531856-1937  CDC14


Ontology Information


   
HPRD ID2878
Molecular ClassReceptor tyrosine phosphatase
Molecular FunctionReceptor signaling complex scaffold activity (GO:0030159)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


View SNP Geneview Report   

Drug Information


Uniprot ID DrugBank ID Name Type
Q13332DB00630AlendronateSmallMoleculeDrug
Q13332DB01077Etidronic acidSmallMoleculeDrug

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO