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General Information
- Evidence
- Gene
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- Protein
- PTM
- Enzyme
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 21949851 | 2011 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | - | Mutation | - | Mononucleotide tracts in the coding regions of the TGFBR2 and BAX genes are commonly mutated in microsatellite instability-high (MSI-high) colon cancers. Role of TGFBR2 or BAX mononucleotide mutation in colorectal cancer as a prognostic biomarker remains uncertain. Compared to MSS/MSI-low cases, MSI-high colorectal cancer is associated with longer cancer-specific survival, regardless of TGFBR2 or BAX mononucleotide tract mutation status. |
| 22811811 | 2010 | Cell line : - Source : UAB Hospital Sample Type : - No. of Sample : - Stage : - | Mutational analysis and Immunohistochemistry | Mutation | - | Bax expression is a candidate prognostic and predictive marker of colorectal cancer. Tissues of CRCs from 56 patients who received a complete regimen of 5-FU-based chemotherapy after surgery, and 56 patients matched for age, gender, ethnicity, tumor stage, tumor location, and tumor differentiation who had undergone only surgery (without any pre- or post-surgery therapy), were evaluated. Ddecreased expression of Bax in CRCs which exhibited mutations in the poly G(8) region of the bax gene. |
| 22997602 | 2012 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | - | Mutation | - | BAX may be used as a marker for CRC. Mutationm due to inactivation of DNA mismatch repair syste,results MSI. |
| 21462329 | 2011 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | Cell cycle analyses, Detection of apoptosis and Immunoblot analyses | Unknown | - | 5OH-PMF isolated from orange, namely 5HHMF and 5HTMF, potently induced apoptosis and cell-cycle arrest in multiple human colon cancer cells. 5OH-PMFs, especially 5HHMF and 5HTMF induce apoptosis and cell cycle arrest by p53, Bax and p21 dependent mechanisms. |
| 21862870 | 2011 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | Cell death assay, Immuno-citochemistry, Histochemical procedures and RT-qPCR. | Unknown | - | Pro-apoptotic effect of PGC1 is mediated by Bax. activation of proteins Bax/Bak is a direct trigger of the outer mitochondrial membrane pore formation for the consequent cyt c release. HCT116 cell line were used. |
| 23180349 | 2012 | Cell line : - Source : - Sample Type : CRC tumor and Normal tissue No. of Sample : 49 Stage : - | Immunohistochemistry | Unknown | - | Bax-negative colorectal cancer may identify a specific phenotype of patients with significantly higher chance to respond to doublet irinotecan-based chemotherapy. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene. [provided by RefSeq, Jul 2008] |
| Chromosome | 19 |
| Location | 19q13.3-q1 |
| Start | 48954860 |
| End | 48961798 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 6939 |
| OMIM ID | 600040 |
| HGNC ID | HGNC:959 |
| Unigene ID | Hs.624291 |
| Ensembl ID | ENSG00000087088 |
| PharmGKB ID | PA25269 |
mRNA Information
| mRNA ID | NM_001291428.1 |
|---|---|
| Exon | join(1..103,689..740,828..974,1339..1474,5951..6055, 6624..6939) | mRNA Sequence | Download Select all |
| Length | 888 |
CDS Information
| Location | join(70..103,689..740,828..974,1339..1474,5951..6055, 6624..6815) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | - |
Protein Information
| Protein ID | NP_001278357.1 |
|---|---|
| Protein Name | BCL2-associated X protein |
| Molecular Wt. (Da) | 24204 |
| Protein Sequence | Download Select all |
| Length | 221 |
| Uniprot ID | Q13740 |
| Ensembl Protein ID | ENSP00000305988 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 87 |
| S | Phosphorylation | 87 |
| S | Phosphorylation | 87 |
| S | Phosphorylation | 87 |
| S | Phosphorylation | 38 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 291 | SLC25A4 | 58 | NP_001142.2 | in vivo;yeast 2-hybrid | 9748162 |
| 596 | BCL2 | 1045 | NP_000624.2 | in vitro;in vivo;yeast 2-hybrid | 911 104 283 587 909 000 000 000 000 000 000 000 000 000 000 |
| 598 | BCL2L1 | 2497 | NP_612815.1 | in vitro;in vivo;yeast 2-hybrid | 1 128 301 891 110 420 000 000 000 000 000 000 000 |
| 637 | BID | 3590 | NP_932070.1 | in vivo;yeast 2-hybrid | 15574335 |
| 2081 | ERN1 | 4943 | NP_001424.3 | in vitro;in vivo | 16645094 |
| 8996 | NOL3 | 5572 | NP_003937.1 | in vivo | 15383280 |
| 10971 | YWHAQ | 886 | NP_006817.1 | in vitro;in vivo | 12426317 |
| 27113 | BBC3 | 16165 | NP_001120712.1 | yeast 2-hybrid | 15574335 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| AGE-RAGE signaling pathway in diabetic complications | hsa04933 |
| Amyotrophic lateral sclerosis (ALS) | hsa05014 |
| Apoptosis | hsa04210 |
| Colorectal cancer | hsa05210 |
| Hepatitis B | hsa05161 |
| HTLV-I infection | hsa05166 |
| Huntington's disease | hsa05016 |
| Longevity regulating pathway - mammal | hsa04211 |
| Neurotrophin signaling pathway | hsa04722 |
| Non-alcoholic fatty liver disease (NAFLD) | hsa04932 |
| p53 signaling pathway | hsa04115 |
| Pathways in cancer | hsa05200 |
| Prion diseases | hsa05020 |
| Protein processing in endoplasmic reticulum | hsa04141 |
| Sphingolipid signaling pathway | hsa04071 |
| Tuberculosis | hsa05152 |
| Viral carcinogenesis | hsa05203 |
Structure Information
| PDB ID | 1F16 |
|---|---|
| Resolution | - |
| Method | SOLUTION NMR� |
| Chains | A |
| Molecule | PROTEIN (APOPTOSIS REGULATOR BAX, MEMBRANE ISOFORM ALPHA) |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| cd06845 | 25-164 | Bcl-2_like |
| cl02575 | 25-164 | Bcl-2_like superfamily |
| smart00337 | 63-158 | BCL |
| pfam00452 | 63-158 | Bcl-2 |
| TIGR00865 | 5-192 | bcl-2 |
Ontology Information
| HPRD ID | 3389 |
|---|---|
| Molecular Class | Adapter molecule |
| Molecular Function | Cell adhesion molecule activity (GO:0005194) |
| Biological Process | Immune response (GO:0006955) |
Drug Information
No matching records could be found.