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General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 19899082 | 2010 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | 2-D Gel electrophoresis ,Western blotting v | Up-regulation | - | - |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes an enzyme that catalyzes the NAD(P)H-dependent conversion of pyrroline-5-carboxylate to proline. This enzyme may also play a physiologic role in the generation of NADP(+) in some cell types. The protein forms a homopolymer and localizes to the mitochondrion. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013] |
| Chromosome | 17 |
| Location | 17q25.3 |
| Start | 79890260 |
| End | 79895203 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 4944 |
| OMIM ID | 179035 |
| HGNC ID | HGNC:9721 |
| Unigene ID | Hs.163451 |
| Ensembl ID | ENSG00000183010 |
| PharmGKB ID | PA34064 |
mRNA Information
| mRNA ID | ?NM_001282280.1 |
|---|---|
| Exon | join(1..67,468..581,1136..1206,1813..1992,2182..2403, 2840..3003,3953..4945) | mRNA Sequence | Download Select all |
| Length | 1811 |
Protein Information
| Protein ID | NP_001269209.1 |
|---|---|
| Protein Name | pyrroline-5-carboxylate reductase 1 |
| Molecular Wt. (Da) | 80971 |
| Protein Sequence | Download Select all |
| Length | 319 |
| Uniprot ID | O15524 |
| Ensembl Protein ID | ENSP00000329418 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Acetylation | 2 |
| S | Acetylation | 2 |
| S | Phosphorylation | 233 |
| S | Phosphorylation | 233 |
| S | Phosphorylation | 303 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Arginine and proline metabolism | hsa00330 |
| Biosynthesis of amino acids | hsa01230 |
| Metabolic pathways | hsa01100 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam14748 | 162-268 | P5CR_dimer |
| cl20674 | 162-268 | P5CR_dimer superfamily |
| pfam03807 | Mar-98 | F420_oxidored |
| cl21454 | Mar-98 | NADB_Rossmann superfamily |
| pfam01210 | 2-104 | NAD_Gly3P_dh_N |
| PLN02688 | 1-268 | PLN02688 |
| COG0345 | 1-268 | ProC |
| PRK11880 | 1-268 | PRK11880 |
| TIGR00112 | 47-267 | proC |
| PRK12491 | 3-274 | PRK12491 |
| PRK07679 | 1-274 | PRK07679 |
| PTZ00431 | 1-268 | PTZ00431 |
| PRK07634 | 1-246 | PRK07634 |
| PRK07680 | 1-254 | PRK07680 |
| PRK06928 | 3-238 | PRK06928 |
| PRK06476 | 1-266 | PRK06476 |
| COG2085 | Jan-95 | COG2085 |
| COG0240 | Jan-99 | GpsA |
| PRK06522 | 1-170 | PRK06522 |
Ontology Information
| HPRD ID | 6795 |
|---|---|
| Molecular Class | Enzyme: Oxidoreductase |
| Molecular Function | Translation regulator activity (GO:0045182) |
| Biological Process | Protein metabolism (GO:0019538) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P32322 | DB00172 | L-Proline | SmallMoleculeDrug |