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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
JAM2 58494 junctional adhesion molecule 2  21VE-JAM, JAM-B, JAMB, CD322 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
26137091   2015Cell line : -

Source : -

Sample Type : CRC tumor and normal tissue

No. of Sample : 26 colorectal cancer, 42 adenoma and 24 normal mucosa samples

Stage : -

-Down-regulation-Downregulation of CLDN5, CLDN8, CLDN23, CLDN15, JAM2 and CGN) in CRC patients.


Gene Details



NC_000021.8 (27011594..27089874)

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Gene Type protein coding
Gene Family CD molecules, "Immunoglobulin superfamily / V-set domain containing", "Immunoglobulin superfamily / I-set domain containing"
Description This gene belongs to the immunoglobulin superfamily, and the junctional adhesion molecule (JAM) family. The protein encoded by this gene is a type I membrane protein that is localized at the tight junctions of both epithelial and endothelial cells. It acts as an adhesive ligand for interacting with a variety of immune cell types, and may play a role in lymphocyte homing to secondary lymphoid organs. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2012]  
Chromosome 21
Location 21q21.2
Start 27011594  
End 27089874  
Strand +  
Gene Sequence

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Length 78281  
OMIM ID 606870   
HGNC ID HGNC:14686   
Unigene ID Hs.517227   
Ensembl ID ENSG00000154721   
PharmGKB ID PA29992   

mRNA Information


mRNA ID ?NM_001270407.1
Exon  
mRNA Sequence

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Length  



CDS Information


   
Location
CDS Sequence

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CCDS ID CCDS42911.1



Protein Information


      
Protein IDNP_001257336.1
Protein Namejunctional adhesion molecule 2
Molecular Wt. (Da)0
Protein Sequence

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Length 298  
Uniprot IDQ9BZD4
Ensembl Protein ID ENSP00000271452  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation280

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                              
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
2151F2RL23561NP_004092.1in vitro;in vivo1   295   305   617   057   640   
7082TJP13002NP_003248.3in vitro;in vivo12953056   


Pathway Information


                        
Pathway Name Pathway ID
Cell adhesion molecules (CAMs) hsa04514
Epithelial cell signaling in Helicobacter pylori infection hsa05120
Leukocyte transendothelial migration hsa04670
Tight junction hsa04530


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd00096151-222  Ig
cl11960151-222  Ig superfamily
cd05750153-221  Ig_Pro_neuregulin
cd05724142-232  Ig2_Robo
cd05760151-221  Ig2_PTK7
cd05746151-222  Ig4_Peroxidasin
cd05736153-221  Ig2_Follistatin_like
cd04978148-222  Ig4_L1-NrCAM_like
cd05733153-221  Ig6_L1-CAM_like
pfam13895137-221  Ig_2
cd05729147-221  Ig2_FGFR_like
cd05730140-221  Ig3_NCAM-1_like
cd05738160-223  Ig2_RPTP_IIa_LAR_like
pfam13927142-218  Ig_3
cd07693140-221  Ig1_Robo
cd05856148-221  Ig2_FGFRL1-like
cd04971160-221  Ig_TrKABC_d5
pfam00047148-216  ig
cd05728160-221  Ig4_Contactin-2-like
cd05748160-221  Ig_Titin_like
cd04968144-221  Ig3_Contactin_like
cd05848151-221  Ig1_Contactin-5
cd05743148-222  Ig_Perlecan_D2_like
cd05726148-221  Ig4_Robo
cd05857147-221  Ig2_FGFR
cd05731159-221  Ig3_L1-CAM_like
cd05773136-221  Ig8_hNephrin_like
cd0571481-130  Ig_CSPGs_LP
cl1196081-130  Ig superfamily
cd04969151-221  Ig5_Contactin_like
cd05875153-221  Ig6_hNeurofascin_like
cd05764148-221  Ig_2
cd05745148-224  Ig3_Peroxidasin
cd05852148-221  Ig5_Contactin-1
cd0587746-130  Ig_LP_like
cd0571382-130  Ig_MOG_like
cd05740151-224  Ig_CEACAM_D4
cd05874153-221  Ig6_NrCAM
cd0009660-112  Ig
cd05867148-221  Ig4_L1-CAM_like
cd05747148-221  Ig5_Titin_like
cd04967151-221  Ig1_Contactin
cd05876159-224  Ig3_L1-CAM
cd0587038-113  Ig5_NCAM-2
cd0587891-130  Ig_Aggrecan_like
cd05870144-221  Ig5_NCAM-2
cd0571736-109  Ig1_Necl-1-3_like
cd0573232-119  Ig5_NCAM-1_like
cd05868160-222  Ig4_NrCAM
cd05732144-221  Ig5_NCAM-1_like
smart0040646-111  IGv
cd0572432-109  Ig2_Robo
cd05725151-221  Ig3_Robo
cd04973142-221  Ig1_FGFR
cd05902102-130  Ig_Neurocan
cd0574894-132  Ig_Titin_like
cd0496989-109  Ig5_Contactin_like
cd05722142-218  Ig1_Neogenin
cd05855160-221  Ig_TrkB_d5
smart00408147-221  IGc2
smart0041035-130  IG_like
pfam07679148-221  I-set
smart00410144-221  IG_like
smart00409144-221  IG
smart0040935-130  IG
pfam0767936-130  I-set
PHA0282693-222  PHA02826


Ontology Information


   
HPRD ID18087
Molecular ClassAdhesion molecule
Molecular FunctionTranscription regulator activity (GO:0030528)
Biological ProcessRegulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO