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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
RAB1A 5861 RAB1A, member RAS oncogene family  2YPT1 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
25446900   2014Cell line : -

Source : -

Sample Type : -

No. of Sample : -

Stage : -

-Up-regulation- Rab1A is overexpressed in colorectal cancer (CRC), which is correlated with elevated mTORC1 signaling, tumor invasion, progression, and poor prognosis.


Gene Details



NC_000002.11 (65313988..65357435, complement)

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Gene Type protein coding
Gene Family RAB, member RAS oncogene
Description This gene encodes a member of the Ras superfamily of GTPases. Members of the gene family cycle between inactive GDP-bound and active GTP-bound forms. This small GTPase controls vesicle traffic from the endoplasmic reticulum to the Golgi apparatus. Multiple alternatively spliced transcript variants have been identified for this gene which encode different protein isoforms. [provided by RefSeq, Oct 2008]  
Chromosome 2
Location 2p14
Start 65313988  
End 65357435  
Strand -  
Gene Sequence

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Length 43448  
OMIM ID 179508   
HGNC ID HGNC:9758   
Unigene ID Hs.310645   
Ensembl ID ENSG00000138069   
PharmGKB ID PA34107   

mRNA Information


mRNA ID ?NM_004161.4
Exon complement(<43294..>43448)  
mRNA Sequence

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Length 5877  



CDS Information


   
Location 215..2488
CDS Sequence

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CCDS ID CCDS46305.1



Protein Information


      
Protein IDNP_004152.1
Protein NameRAB1A, member RAS oncogene family
Molecular Wt. (Da)24477
Protein Sequence

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Length 205  
Uniprot IDQ9Y4H2
Ensembl Protein ID ENSP00000365016  



Post-translational Modification Information (Source : HPRD)


Residue Type site
CPrenylation204
CPrenylation205
SAcetylation2
TPhosphorylation37
SPhosphorylation194

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                       
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
1122CHML341NP_001812.2in vitro97   308   288   294   464   
6624FSCN14068NP_003079.1yeast 2-hybrid16169070   
6861SYT52870NP_003171.2yeast 2-hybrid16169070   
22924MAPRE316156NP_036458.2yeast 2-hybrid16169070   
23539SLC16A811568NP_037488.2yeast 2-hybrid16169070   
51042ZNF59315866NP_056955.2yeast 2-hybrid16169070   
55312RFK17969NP_060809.2yeast 2-hybrid16169070   
57143ADCK110630NP_065154.2yeast 2-hybrid16169070   
79735TBC1D1715471NP_078958.1yeast 2-hybrid16169070   


Pathway Information


      
Pathway Name Pathway ID
Legionellosis hsa05134


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd0186910-175  Rab1_Ypt1
cl2145510-175  P-loop_NTPase superfamily
cd018679-175  Rab8_Rab10_Rab13_like
smart0017512-175  RAB
cd0015412-169  Rab
cd041107-205  Rab35
cd018689-172  Rab11_like
cd0186312-172  Rab18
cd018649-172  Rab19
cd018668-175  Rab2
cd0186012-172  Rab5_related
cd041147-172  Rab30
cd0186511-165  Rab3
cd0411110-179  Rab39
cd0411712-169  Rab15
cd0412013-176  Rab12
cd0186112-172  Rab6
cd0411512-173  Rab33B_Rab33A
cd0411312-172  Rab4
cd0412210-172  Rab14
cd0186212-169  Rab7
cd041278-176  Rab27A
cd0411212-175  Rab26
cd0412312-172  Rab21
cd0087613-172  Ras
cd0410712-205  Rab32_Rab38
cd041218-192  Rab40
smart0001012-175  small_GTPase
smart0017312-175  RAS
cd0413912-174  RalA_RalB
cd0411611-165  Rab9
cd0411913-172  RJL
cd0413812-173  H_N_K_Ras_like
cd0413713-184  RheB
cd0414512-168  M_R_Ras_like
cd0410613-170  Rab23_like
cd0417612-172  Rap2
cd0410912-172  Rab28
cd0410813-170  Rab36_Rab34
cd0015713-165  Rho
cd0413612-172  Rap_like
cd0417512-174  Rap1
cd0417712-172  RSR1
cd0412413-165  RabL2
smart0017414-165  RHO
cd0414413-187  Ras2
cd0410113-170  RabL4
cd0411813-205  Rab24
cd041329-182  Rho4_like
cd0088215-169  Ras_like_GTPase
cd0087712-169  Ran
cd0414112-175  Rit_Rin_Ric
cd0414613-165  RERG_RasL11_like
cd0414012-165  ARHI_like
cd0412913-205  Rho2
cd0412813-165  Spg1
cd0413313-167  Rop_like
cd0413013-165  Wrch_1
cd0187013-167  RhoA_like
pfam0847713-127  Miro
cd0414812-175  RGK
cd0087813-165  Arf_Arl
cd0187513-165  RhoG
cd0417213-160  Rnd3_RhoE_Rho8
cd0991413-162  RocCOR
cd0413113-170  Rnd
cd0413413-170  Rho3
cd0412613-205  Rab20
cd0414713-178  Ras_dva
cd0417313-149  Rnd2_Rho7
cd0413512-128  Tc10
cd0417413-149  Rnd1_Rho6
cd0415916-163  Arl10_like
cd0187113-165  Rac1_like
cd041531-148  Arl5_Arl8
cd0416015-164  Arfrp1
cd0414312-170  Rhes_like
smart0017713-148  ARF
pfam0002512-129  Arf
cd0187413-141  Cdc42
cd0415212-128  Arl4_Arl7
cd0189313-165  Miro1
PTZ0013313-176  PTZ00133
cd0087913-177  Sar1
cd0415613-128  ARLTS1
PLN0022313-148  PLN00223
cd0415513-146  Arl3
cd0414913-148  Arf6
cd0410213-127  RabL3
cd0415013-148  Arf1_5_like
PLN0002313-131  PLN00023
cd0415412-128  Arl2
cd0414212-128  RRP22
COG222913-157  Srp102
cd0187311-165  RhoBTB
cd0415113-153  Arl1
cd0410313-172  Centaurin_gamma
cd0416214-130  Arl9_Arfrp2_like
cd0410515-132  SR_beta
cd0415813-92  ARD1
cd0415714-161  Arl6
cd0416412-163  trmE
cd0189211-149  Miro2
cd0416114-128  Arl2l1_Arl13_like
cd0184987-181  YlqF_related_GTPase
pfam0192616-119  MMR_HSR1
cd01850Dec-69  CDC_Septin
cd0088016-170  Era_like
pfam0000943-162  GTP_EFTU
pfam0007113-174  Ras
PLN031088-205  PLN03108
PLN031107-205  PLN03110
PLN031182-205  PLN03118
COG11008-205  Gem1
TIGR0023112-165  small_GTP
PTZ0009934-172  PTZ00099
PTZ0036912-187  PTZ00369
PTZ0013212-169  PTZ00132
PLN0307112-169  PLN03071
smart0017617-172  RAN
COG048612-163  MnmE
PRK0529152-186  trmE
COG116187-180  RbgA
pfam0467013-116  Gtr1_RagA
smart0017813-127  SAR
TIGR0045012-162  mnmE_trmE_thdF
pfam0943915-132  SRPRB


Ontology Information


   
HPRD ID4885
Molecular ClassGTPase
Molecular FunctionTranslation regulator activity (GO:0045182)
Biological ProcessProtein metabolism (GO:0019538); Translation (GO:0043037)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO