Search results:


General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
RAC1 5879 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)  7TC-25, p21-Rac1, Rac-1 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
24833563   2014Cell line : -

Source : Spain

Sample Type : CRCTumor

No. of Sample : 157

Stage : TNM Stage IV.

Mutation analysis, Genotyping, MSI analysis,real time RT-PCRUp-regulation--

25171475   2014Cell line : Lovo

Source : -

Sample Type : -

No. of Sample : -

Stage : -

 Western blottingUp-regulation- Rac1�protein was overexpressed in human�colorectal cancer�cells and in human�colorectal�tissue

25529012   2015Cell line : -

Source : Southwest Hospital, Third Military Medical University

Sample Type : CRC Tumor

No. of Sample : 187

Stage : -

Western blotting, Real-time RT-PCR,Flow cytometry,MicroarrayUp-regulation-GTP-Rac1 expression was inversely correlated with SEMA3F levels in CRC samples and patients with SEMA3F(low)/GTP-Rac1(high) CRC showed poorer prognosis.


Gene Details



NC_000007.13 (6414126..6443598)

View Larger Image
   
Gene Type protein coding
Gene Family Endogenous ligands
Description The protein encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]  
Chromosome 7
Location 7p22
Start 6414126  
End 6443598  
Strand +  
Gene Sequence

   Download   Select all

Length 29473  
OMIM ID 602048   
HGNC ID HGNC:9801   
Unigene ID Hs.413812   
Ensembl ID ENSG00000136238   
PharmGKB ID PA34162   

mRNA Information


mRNA ID ?NM_006908.4
Exon join(1..276,12718..12789,17430..17547,24168..24224, 25632..25694,27374..27533,27822..29473)  
mRNA Sequence

   Download   Select all

Length 2398  



CDS Information


   
Location 242..877
CDS Sequence

   Download   Select all

CCDS ID CCDS5348.1



Protein Information


      
Protein IDNP_008839.2
Protein Nameras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
Molecular Wt. (Da)71559
Protein Sequence

   Download   Select all

Length 192  
Uniprot IDO15372
Ensembl Protein ID ENSP00000429931  



Post-translational Modification Information (Source : HPRD)


Residue Type site
CMethylation208
CMethylation145
SPhosphorylation71
SPhosphorylation71
SPhosphorylation27

Enzyme Information


No matching records could be found.

PPi Information


No STRING Network could be found.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
58ACTA130NP_001091.1in vivo11027608   
60ACTB32NP_001092.1in vitro;in vivo11027608   
396ARHGDIA3565NP_004300.1in vitro;in vivo;yeast 2-hybrid115   135   791   067   342   000   000   000   
857CAV13028NP_001744.2in vivo15976327   
1123CHN1319NP_001813.1in vitro8496137   
1535CYBA1989NP_000092.2in vitro10486263   
1856DVL23690NP_004413.1in vivo12533515   
2316FLNA2060NP_001104026.1in vivo10051605   
3895KTN12661NP_891556.1yeast 2-hybrid8769096   
4216MAP3K43886NP_005913.2in vitro9305638   
4296MAP3K112502NP_002410.1in vitro9427749   
4688NCF21991NP_000424.2in vitro;in vivo;yeast 2-hybrid11   090   627   118   960   600   000   000   000   000   000   000   000   000   000   
4690NCK12740NP_006144.1in vivo10766742   
4843NOS21225NP_000616.3in vitro;yeast 2-hybrid1   145   772   511   422   780   
4983OPHN12130NP_002538.1in vitro119   986   879   582   072   
5295PIK3R11381NP_852664.1in vitro1   208   687   680   346   240   000   000   
5364PLXNB13032NP_002664.2in vitro;in vivo12123608   
5521PPP2R2B5059NP_858062.1in vivo17245428   
5578PRKCA1498NP_002728.1in vivo11284700   
5580PRKCD1501NP_006245.2in vivo19356729   
5584PRKCI2105NP_002731.4in vivo11260256   
5610EIF2AK21468NP_002750.1in vitro7738010   
5923RASGRF17362Q13972in vitro;in vivo10220378   
6772STAT12777NP_009330.1in vivo15494521   
6774STAT326NP_644805.1in vivo;yeast 2-hybrid11021801   
6780STAU13422NP_059347.2in vitro15121898   
7074TIAM12820NP_003244.2in vitro;in vivo1   159   574   911   130   060   
7097TLR24323NP_003255.2in vivo11101877   
7204TRIO3537NP_009049.2in vitro;in vivo11595749   
7277TUBA4A1851NP_005991.1in vivo8631991   
7454WAS2314NP_000368.1in vivo8643625   
8874ARHGEF75688NP_001106983.1in vitro14557270   
10988METAP23522NP_006829.1in vitro7738010   
84612PARD6B18703NP_115910.1in vitro;yeast 2-hybrid11260256   


Pathway Information


                                                                                                                                                                                                                                    
Pathway Name Pathway ID
Adherens junction hsa04520
AGE-RAGE signaling pathway in diabetic complications hsa04933
Amyotrophic lateral sclerosis (ALS) hsa05014
Axon guidance hsa04360
B cell receptor signaling pathway hsa04662
Bacterial invasion of epithelial cells hsa05100
cAMP signaling pathway hsa04024
Chemokine signaling pathway hsa04062
Choline metabolism in cancer hsa05231
Colorectal cancer hsa05210
Epithelial cell signaling in Helicobacter pylori infection hsa05120
Fc epsilon RI signaling pathway hsa04664
Fc gamma R-mediated phagocytosis hsa04666
Focal adhesion hsa04510
Leukocyte transendothelial migration hsa04670
MAPK signaling pathway hsa04010
Natural killer cell mediated cytotoxicity hsa04650
Neurotrophin signaling pathway hsa04722
Non-alcoholic fatty liver disease (NAFLD) hsa04932
Osteoclast differentiation hsa04380
Pancreatic cancer hsa05212
Pancreatic secretion hsa04972
Pathways in cancer hsa05200
Phagosome hsa04145
PI3K-Akt signaling pathway hsa04151
Proteoglycans in cancer hsa05205
Rap1 signaling pathway hsa04015
Ras signaling pathway hsa04014
Regulation of actin cytoskeleton hsa04810
Renal cell carcinoma hsa05211
Salmonella infection hsa05132
Shigellosis hsa05131
Sphingolipid signaling pathway hsa04071
Toll-like receptor signaling pathway hsa04620
VEGF signaling pathway hsa04370
Viral carcinogenesis hsa05203
Viral myocarditis hsa05416
Wnt signaling pathway hsa04310


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd018713-176  Rac1_like
cl214553-176  P-loop_NTPase superfamily
smart001746-179  RHO
cd001574-175  Rho
cd018751-192  RhoG
cd018744-177  Cdc42
cd041324-192  Rho4_like
cd041304-175  Wrch_1
cd041333-177  Rop_like
cd041354-177  Tc10
cd018705-177  RhoA_like
cd041295-177  Rho2
cd041314-177  Rnd
cd041345-189  Rho3
cd041722-175  Rnd3_RhoE_Rho8
cd041735-169  Rnd2_Rho7
cd041745-192  Rnd1_Rho6
cd001544-174  Rab
cd018734-175  RhoBTB
cd008765-174  Ras
smart001754-177  RAB
smart001735-176  RAS
smart000105-176  small_GTPase
cd041234-170  Rab21
cd018615-170  Rab6
cd041445-192  Ras2
cd008827-174  Ras_like_GTPase
cd041385-176  H_N_K_Ras_like
cd041775-178  RSR1
cd041455-176  M_R_Ras_like
cd018634-176  Rab18
cd018625-177  Rab7
cd041365-176  Rap_like
cd018674-177  Rab8_Rab10_Rab13_like
cd018605-177  Rab5_related
cd041765-174  Rap2
cd041117-161  Rab39
cd041064-122  Rab23_like
cd041395-176  RalA_RalB
cd018932-179  Miro1
cd018695-159  Rab1_Ypt1
cd041274-161  Rab27A
cd018665-177  Rab2
cd008774-123  Ran
cd041415-189  Rit_Rin_Ric
cd041135-176  Rab4
cd041465-176  RERG_RasL11_like
cd041375-191  RheB
cd041755-176  Rap1
cd018685-169  Rab11_like
cd041125-161  Rab26
cd041164-176  Rab9
cd041175-169  Rab15
cd041184-169  Rab24
cd041105-189  Rab35
cd041155-121  Rab33B_Rab33A
pfam084775-118  Miro
cd041015-175  RabL4
cd041225-176  Rab14
cd018645-169  Rab19
cd041244-119  RabL2
cd041284-128  Spg1
cd018655-178  Rab3
cd041085-169  Rab36_Rab34
cd041194-177  RJL
cd041145-171  Rab30
cd041405-173  ARHI_like
cd041485-176  RGK
cd099144-138  RocCOR
cd041075-175  Rab32_Rab38
cd041475-188  Ras_dva
cd041207-182  Rab12
cd041214-189  Rab40
cd041094-119  Rab28
cd041424-178  RRP22
cd041437-169  Rhes_like
cd041264-185  Rab20
cd018924-119  Miro2
cd041522-186  Arl4_Arl7
cd00880107-174  Era_like
pfam00025Feb-80  Arf
cd041535-165  Arl5_Arl8
cd04163107-171  Era
cd01897107-177  NOG
cd041598-135  Arl10_like
pfam000715-177  Ras
COG11001-177  Gem1
TIGR002314-157  small_GTP
PTZ001324-123  PTZ00132
PTZ003691-192  PTZ00369
PLN031183-171  PLN03118
PLN030713-135  PLN03071
PLN031085-169  PLN03108
smart001769-135  RAN
PLN031105-169  PLN03110
PTZ0009926-171  PTZ00099
TIGR03594109-187  GTPase_EngA
PRK00089106-171  era
PRK00093109-187  PRK00093
PRK12299109-177  obgE


Ontology Information


   
HPRD ID5087
Molecular ClassGTPase
Molecular FunctionReceptor signaling complex scaffold activity (GO:0030159)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


View SNP Geneview Report   

Drug Information


Uniprot ID DrugBank ID Name Type
P63000DB00514DextromethorphanSmallMoleculeDrug

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO