Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| RAD21 | 5885 | RAD21 homolog (S. pombe) | 8 | KIAA0078, hHR21, SCC1 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 24548858 | 2014 | Cell line : - Source : St Vincent's Hospital, Sydney and the John Radcliffe Hospital, Oxford, UK. Sample Type : CRC tumor No. of Sample : 652 Stage : TNM Stage I-IV | Tissue microarray,immunohistochemistry,DNA Methylation,Western blotting | Up-regulation | - | RAD21 expression in CRC is associated with aggressive disease especially in KRAS mutant tumours and resistance to chemoradiotherapy. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad21, a gene involved in the repair of DNA double-strand breaks, as well as in chromatid cohesion during mitosis. This protein is a nuclear phospho-protein, which becomes hyperphosphorylated in cell cycle M phase. The highly regulated association of this protein with mitotic chromatin specifically at the centromere region suggests its role in sister chromatid cohesion in mitotic cells. [provided by RefSeq, Jul 2008] |
| Chromosome | 8 |
| Location | 8q24.11 |
| Start | 117858173 |
| End | 117887105 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 28933 |
| OMIM ID | 606462 |
| HGNC ID | HGNC:9811 |
| Unigene ID | Hs.81848 |
| Ensembl ID | ENSG00000164754 |
| PharmGKB ID | PA34170 |
mRNA Information
| mRNA ID | ?NM_006265.2 |
|---|---|
| Exon | join(1..256,8106..8281,11608..11737,12927..13026, 16409..16515,17394..17600,18096..18221,18579..18701, 20399..20622,22159..22318,22771..22919,24100..24249, 25838..25921,27176..28933) | mRNA Sequence | Download Select all |
| Length | 3773 |
Protein Information
| Protein ID | NP_006256.1 |
|---|---|
| Protein Name | RAD21 homolog (S. pombe) |
| Molecular Wt. (Da) | 94559 |
| Protein Sequence | Download Select all |
| Length | 631 |
| Uniprot ID | Q13347 |
| Ensembl Protein ID | ENSP00000362688 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| D | Proteolytic Cleavage | 279 |
| D | Proteolytic Cleavage | 279 |
| S | Phosphorylation | 46 |
| S | Phosphorylation | 153 |
| S | Phosphorylation | 175 |
| T | Phosphorylation | 186 |
| S | Phosphorylation | 9 |
| S | Phosphorylation | 342 |
| S | Phosphorylation | 345 |
| T | Phosphorylation | 350 |
| S | Phosphorylation | 374 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 4926 | NUMA1 | 1236 | CAA77669.1 | in vivo | 11590136 |
| 8243 | SMC1A | 2077 | NP_006297.2 | in vivo | 10931856 |
| 8467 | SMARCA5 | 4538 | NP_003592.2 | in vitro | 12198550 |
| 10274 | STAG1 | 5076 | NP_005853.2 | in vivo | 11590136 |
| 10735 | STAG2 | 5077 | NP_001036214.1 | in vivo | 1 159 013 612 034 750 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Cell cycle | hsa04110 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam04825 | 1-111 | Rad21_Rec8_N |
| cl04781 | 1-111 | Rad21_Rec8_N superfamily |
| pfam04824 | 574-628 | Rad21_Rec8 |
| cl04780 | 574-628 | Rad21_Rec8 superfamily |
Ontology Information
| HPRD ID | 4579 |
|---|---|
| Molecular Class | DNA binding protein |
| Molecular Function | Transporter activity (GO:0005215) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.