Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| RAD51 | 5888 | RAD51 recombinase | 15 | HsRad51, HsT16930, BRCC5 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23065657 | 2013 | Cell line : - Source : University Hospital of Basel and University Medical Center Hamburg-Eppendorf Sample Type : CRC tumor and normal tissue No. of Sample : 1213 CRC patients Stage : - | Tissue microarray and immunohistochemistry | Up-regulation | - | Overexpression of RAD51 is a predictor of poor outcome in CRC. RAD51 ay be study as a prognostic marker and therapeutic target. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | |
| Description | The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. This protein is also found to interact with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both the intracellular localization and DNA-binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Multiple transcript variants encoding different isoforms have been found for this gene. |
| Chromosome | 15 |
| Location | 15q15.1 |
| Start | 40694774 |
| End | 40732158 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 37385 |
| OMIM ID | 179617 |
| HGNC ID | HGNC:9817 |
| Unigene ID | Hs.631709 |
| Ensembl ID | ENSG00000051180 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | XM_011521861.1 |
|---|---|
| Exon | join(1..47,3984..4072,6291..6428,11404..11521, 14252..14343,24032..24126,33938..34051,34732..34861, 36282..37385) | mRNA Sequence | Download Select all |
| Length | 2147 |
CDS Information
| Location | join(3986..4072,6291..6428,7033..7153,14252..14343, 24032..24126,33938..34051,34732..34861,35080..35201, 36282..36405) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS53931.1 |
Protein Information
| Protein ID | NP_001157741.1 |
|---|---|
| Protein Name | RAD51 recombinase |
| Molecular Wt. (Da) | 36649 |
| Protein Sequence | Download Select all |
| Length | 340 |
| Uniprot ID | P11021 |
| Ensembl Protein ID | ENSP00000324173 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| Y | Phosphorylation | 315 |
| Y | Phosphorylation | 54 |
| D | Proteolytic Cleavage | 188 |
| Y | Phosphorylation | 54 |
| D | Proteolytic Cleavage | 187 |
| D | Proteolytic Cleavage | 274 |
| D | Proteolytic Cleavage | 275 |
| D | Proteolytic Cleavage | 188 |
| D | Proteolytic Cleavage | 187 |
| D | Proteolytic Cleavage | 274 |
| D | Proteolytic Cleavage | 275 |
| T | Phosphorylation | 309 |
Enzyme Information
No matching records could be found.
PPi Information
No STRING Network could be found.
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 672 | BRCA1 | 218 | NP_009231.2 | in vivo | 97 749 709 008 167 |
| 1107 | CHD3 | 9071 | NP_001005271.2 | yeast 2-hybrid | 16169070 |
| 5889 | RAD51C | 4143 | NP_478123.1 | in vivo | 16395335 |
| 7431 | VIM | 1899 | NP_003371.2 | yeast 2-hybrid | 16169070 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Fanconi anemia pathway | hsa03460 |
| Homologous recombination | hsa03440 |
| Pancreatic cancer | hsa05212 |
| Pathways in cancer | hsa05200 |
Structure Information
| PDB ID | 1B22 |
|---|---|
| Resolution | |
| Method | SOLUTION NMR |
| Chains | A |
| Molecule | DNA REPAIR PROTEIN RAD51 |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| cd01123 | 102-335 | Rad51_DMC1_radA |
| cl21455 | 102-335 | P-loop_NTPase superfamily |
| cd01393 | 102-327 | recA_like |
| PRK09361 | 102-334 | radB |
| cd01394 | 102-334 | radB |
| cd01120 | 122-304 | RecA-like_NTPases |
| pfam13481 | 95-266 | AAA_25 |
| pfam14520 | 32-80 | HHH_5 |
| cl22429 | 32-80 | ENDO3c superfamily |
| PRK06067 | 102-266 | PRK06067 |
| cd00983 | 102-305 | recA |
| TIGR03880 | 105-266 | KaiC_arch_3 |
| TIGR03881 | 101-167 | KaiC_arch_4 |
| cd01121 | 94-269 | Sms |
| COG2874 | 102-141 | FlaH |
| TIGR01954 | 33-78 | nusA_Cterm_rpt |
| PRK08533 | 98-141 | PRK08533 |
| TIGR02239 | 25-339 | recomb_RAD51 |
| PTZ00035 | 4-339 | PTZ00035 |
| PLN03186 | 1-339 | PLN03186 |
| pfam08423 | 83-338 | Rad51 |
| PLN03187 | 4-339 | PLN03187 |
| TIGR02238 | 25-337 | recomb_DMC1 |
| PRK04301 | 32-337 | radA |
| TIGR02236 | 32-336 | recomb_radA |
| COG0468 | 62-337 | RecA |
| TIGR02237 | 109-334 | recomb_radB |
| COG1066 | 59-269 | Sms |
| PRK09519 | 94-327 | recA |
| COG0467 | 99-275 | RAD55 |
| smart00382 | 119-306 | AAA |
| TIGR02012 | 93-304 | tigrfam_recA |
| TIGR00416 | 95-302 | sms |
| PRK09302 | 88-163 | PRK09302 |
| pfam00154 | 94-304 | RecA |
| PRK09202 | 39-80 | nusA |
| PRK12766 | 32-81 | PRK12766 |
Ontology Information
| HPRD ID | 9076 |
|---|---|
| Molecular Class | DNA binding protein |
| Molecular Function | Chaperone activity (GO:0003754) |
| Biological Process | Protein metabolism (GO:0019538) |
Drug Information
No matching records could be found.