Search results:


General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
RARA 5914 retinoic acid receptor, alpha  17RAR, NR1B1 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
18305945   2008Cell line : -

Source : Konkuk University Hospital Chungju South Korea.

Sample Type : CRC Tumor and adjecent normal tissue.

No. of Sample : 5

Stage : -

Oligonucleotide microarrays,real time RT-PCR,Significance Analysis of Microarray Up-regulation-Three genes (TNFRSF10A, BENE, RARA) with strongly significant expression intensities.


Gene Details



NC_000017.10 (38465423..38513895)

View Larger Image
   
Gene Type protein coding
Gene Family Nuclear hormone receptors
Description This gene represents a nuclear retinoic acid receptor. The encoded protein, retinoic acid receptor alpha, regulates transcription in a ligand-dependent manner. This gene has been implicated in regulation of development, differentiation, apoptosis, granulopoeisis, and transcription of clock genes. Translocations between this locus and several other loci have been associated with acute promyelocytic leukemia. Alternatively spliced transcript variants have been found for this locus.[provided by RefSeq, Sep 2010]  
Chromosome 17
Location 17q21.1
Start 38465423  
End 38513895  
Strand +  
Gene Sequence

   Download   Select all

Length 48473  
OMIM ID 180240   
HGNC ID HGNC:9864   
Unigene ID Hs.654583   
Ensembl ID ENSG00000131759   
PharmGKB ID PA34225   

mRNA Information


mRNA ID ?NM_000964.3
Exon join(1..116,21687..22226,39146..39294,40614..40755, 42740..42900,43161..43337,45132..45336,46093..46251, 46839..48473)  
mRNA Sequence

   Download   Select all

Length 3301  



CDS Information


   
Location479..1867
CDS Sequence

   Download   Select all

CCDS ID CCDS11366.1



Protein Information


      
Protein IDNP_000955.1
Protein Nameretinoic acid receptor, alpha
Molecular Wt. (Da)50358
Protein Sequence

   Download   Select all

Length 462  
Uniprot IDQ12891
Ensembl Protein ID ENSP00000350387  



Post-translational Modification Information (Source : HPRD)


No matching records could be found.

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                                                                                                                                                                                                                                                                                                                    
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
573BAG13292NP_004314.4in vivo;yeast 2-hybrid9642262   
688KLF54212NP_001721.2in vitro;in vivo12101409   
896CCND3452NP_001751.1in vitro;in vivo;yeast 2-hybrid12482873   
1022CDK715993NP_001790.1in vitro;yeast 2-hybrid15249124   
2908NR3C1679NP_001019265.1yeast 2-hybrid17641689   
5371PML23NP_150241.2in vitro129   359   271   311   253   
5451POU2F11250NP_002688.2in vitro10480874   
5469MED15055NP_004765.2in vitro;in vivo965   311   917   641   689   
6256RXRA1577NP_002948.1yeast 2-hybrid108   820   701   310   351   000   000   000   000   000   000   000   000   
6667SP11796NP_612482.2in vitro;in vivo10361124   
6777STAT5B5037NP_036580.2in vitro11929748   
7068THRB7521NP_000452.2yeast 2-hybrid17641689   
7080NKX2-12798NP_001073136.1in vitro1   061   758   511   274   140   
7337UBE3A3375NP_000453.2yeast 2-hybrid16713569   
7376NR1H22660NP_009052.3yeast 2-hybrid15604093   
8204NRIP13927NP_003480.2in vitro;yeast 2-hybrid105   313   311   671   356   000   000   000   
8431NR0B25219NP_068804.1in vitro;yeast 2-hybrid9773978   
8648NCOA14070NP_003734.3in vitro;yeast 2-hybrid12   138   096   126   655   800   000   000   000   000   000   
8805TRIM244556NP_056989.2in vivo9115274   
9325TRIP45140NP_057297.2in vitro;in vivo10454579   
9588PRDX63817NP_004896.1yeast 2-hybrid15604093   
9612NCOR22910NP_006303.3in vitro;in vivo;yeast 2-hybrid756   612   715   604   093   
10002NR2E35132NP_055064.1in vitro10611353   
10474TADA34252NP_006345.1in vitro;in vivo12235159   
10912GADD45G5383NP_006696.1in vitro10872826   
23054NCOA65599NP_054790.2in vivo10567404   
26548ITGB1BP22271NP_036410.1yeast 2-hybrid15604093   
55629PNRC217871NP_060231.1yeast 2-hybrid11574675   


Pathway Information


                  
Pathway Name Pathway ID
Acute myeloid leukemia hsa05221
Pathways in cancer hsa05200
Transcriptional misregulation in cancer hsa05202


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd06937186-416  NR_LBD_RAR
cl11397186-416  NR_LBD superfamily
cd0696482-166  NR_DBD_RAR
cl0259682-166  NR_DBD_like superfamily
cd06929224-395  NR_LBD_F1
cd06935221-413  NR_LBD_TR
cd06954186-413  NR_LBD_LXR
cd0691688-159  NR_DBD_like
pfam0010586-155  zf-C4
cd0696187-162  NR_DBD_TR
cd06938240-412  NR_LBD_EcR
cd06157228-387  NR_LBD
cd06941222-415  NR_LBD_DmE78_like
cd0696088-162  NR_DBD_HNF4A
cd06940223-400  NR_LBD_REV_ERB
smart0039987-156  ZnF_C4
cd0696887-162  NR_DBD_ROR
cd0696788-162  NR_DBD_TR2_like
cd0716788-162  NR_DBD_Lrh-1_like
cd0716588-162  NR_DBD_DmE78_like
cd06945186-415  NR_LBD_Nurr1_like
cd0696986-159  NR_DBD_NGFI-B
cd0716886-162  NR_DBD_DHR4_like
cd0716687-162  NR_DBD_REV_ERB
cd0716986-162  NR_DBD_GCNF_like
cd0715888-159  NR_DBD_Ppar_like
cd06932236-412  NR_LBD_PPAR
cd06943233-393  NR_LBD_RXR_like
cd0695688-162  NR_DBD_RXR
cd0696587-162  NR_DBD_Ppar
cd0717988-160  2DBD_NR_DBD2
cd07072187-417  NR_LBD_DHR38_like
cd0695888-159  NR_DBD_COUP_TF
cd0716387-162  NR_DBD_TLX
cd0715588-162  NR_DBD_ER_like
cd0716488-162  NR_DBD_PNR_like_1
smart00430232-387  HOLI
cd06939183-413  NR_LBD_ROR_like
cd0717188-162  NR_DBD_ER
cd0717088-162  NR_DBD_ERR
cd0715488-159  NR_DBD_PNR_like
cd0715688-158  NR_DBD_VDR_like
cd0695788-162  NR_DBD_PNR_like_2
cd07348187-424  NR_LBD_NGFI-B
cd0697088-162  NR_DBD_PNR
cd0716188-161  NR_DBD_EcR
cd0695988-158  NR_DBD_EcR_like
cd06934180-413  NR_LBD_PXR_like
pfam00104207-395  Hormone_recep
cd0696686-156  NR_DBD_CAR
cd0696288-156  NR_DBD_FXR
cd07071187-423  NR_LBD_Nurr1
cd0716288-161  NR_DBD_PXR
cd0716088-158  NR_DBD_LXR
cd07068229-415  NR_LBD_ER_like
cd0695586-161  NR_DBD_VDR
cd06930230-387  NR_LBD_F2
cd06933180-416  NR_LBD_VDR
cd06936228-399  NR_LBD_Fxr
cd06946229-415  NR_LBD_ERR
cd0715786-155  2DBD_NR_DBD1
cd06948208-414  NR_LBD_COUP-TF
cd0717386-154  NR_DBD_AR
cd0717286-153  NR_DBD_GR_PR
cd0696388-157  NR_DBD_GR_like
cd06931236-413  NR_LBD_HNF4_like
cd06949229-415  NR_LBD_ER
cd06942223-385  NR_LBD_Sex_1_like
cd06952239-393  NR_LBD_TR2_like
cd06953213-390  NR_LBD_DHR4_like
cd06950230-395  NR_LBD_Tlx_PNR_like
cd07069230-414  NR_LBD_Lrh-1
cd06944239-414  NR_LBD_Ftz-F1_like
cd07070230-415  NR_LBD_SF-1
cd07075224-335  NR_LBD_MR
cd07074224-335  NR_LBD_PR
cd07073224-298  NR_LBD_AR
cd06947230-298  NR_LBD_GR_Like
pfam1193619-68  DUF3454
cl1338719-68  DUF3454 superfamily


Ontology Information


   
HPRD ID4522
Molecular ClassNuclear receptor
Molecular FunctionPeptidase activity (GO:0008233)
Biological ProcessProtein metabolism (GO:0019538)  



SNP Information


View SNP Geneview Report   

Drug Information


Uniprot ID DrugBank ID Name Type
P10276DB00210AdapaleneSmallMoleculeDrug
P10276DB00459AcitretinSmallMoleculeDrug
P10276DB00523AlitretinoinSmallMoleculeDrug
P10276DB00799TazaroteneSmallMoleculeDrug
P10276DB00982IsotretinoinSmallMoleculeDrug
P10276DB04942TamibaroteneSmallMoleculeDrug

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO