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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
RASGRF1 5923 Ras protein-specific guanine nucleotide-releasing factor 1  15CDC25L, CDC25, GRF55, H-GRF55, GNRP, PP13187 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
19826040   2009Cell line : RKO, DLD1

Source : -

Sample Type : -

No. of Sample : -

Stage : -

Unbiased microarray analysis combined with bioinformatics, RT-PCR, and Northern blottingUp-regulation-Data show a role of miR-21 in modulating cell cycle progression following stress, providing a novel mechanism of Cdc25A regulation and a potential explanation of miR-21 in tumorigenesis.


Gene Details



NC_000015.9 (79252289..79383215, complement)

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Gene Type protein coding
Gene Family Rho guanine nucleotide exchange factors, "Pleckstrin homology (PH) domain containing"
Description The protein encoded by this gene is a guanine nucleotide exchange factor (GEF) similar to the Saccharomyces cerevisiae CDC25 gene product. Functional analysis has demonstrated that this protein stimulates the dissociation of GDP from RAS protein. The studies of the similar gene in mouse suggested that the Ras-GEF activity of this protein in brain can be activated by Ca2+ influx, muscarinic receptors, and G protein beta-gamma subunit. Mouse studies also indicated that the Ras-GEF signaling pathway mediated by this protein may be important for long-term memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Mar 2009]  
Chromosome 15
Location 15q24
Start 79252289  
End 79383215  
Strand -  
Gene Sequence

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Length 130927  
OMIM ID 606600   
HGNC ID HGNC:9875   
Unigene ID Hs.459035   
Ensembl ID ENSG00000058335   
PharmGKB ID PA34238   

mRNA Information


mRNA ID ?NM_002891.4
Exon join(1..651,26348..26454,32393..32540,41286..41378, 43875..44128,55664..55743,58558..58751,59365..59474, 63015..63133,65400..65560,70770..70833,72968..73104, 75465..75547,84440..84688,86699..87072,89087..89212, 90961..91131,92049..92155,92666..92778,95074..95134, 99080..99183,100601..100685,105670..105867,110175..110254, 117454..117571,118940..119008,128638..130927)  
mRNA Sequence

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Length 6366  



CDS Information


   
Location 376..4149
CDS Sequence

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CCDS ID CCDS10309.1



Protein Information


      
Protein IDNP_002882.3
Protein NameRas protein-specific guanine nucleotide-releasing factor 1
Molecular Wt. (Da)201434
Protein Sequence

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Length 1273  
Uniprot IDO43292
Ensembl Protein ID ENSP00000347206  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation929
SPhosphorylation927
SPhosphorylation143

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                        
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
387RHOA1323NP_001655.1in vivo10220378   
4914NTRK11869NP_002520.2in vivo15513915   
4915NTRK22712NP_006171.2in vivo15513915   
4916NTRK31870NP_001012338.1in vivo15513915   
7531YWHAE5457NP_006752.1in vitro;in vivo;yeast 2-hybrid11533041   
9101USP84405NP_005145.3in vitro;in vivo;yeast 2-hybrid11500497   
10188TNK26104NP_001010938.1in vitro10882715   
22800RRAS22518NP_036382.2in vitro12384139   


Pathway Information


                  
Pathway Name Pathway ID
Focal adhesion hsa04510
MAPK signaling pathway hsa04010
Ras signaling pathway hsa04014


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd1326119-154  PH_RasGRF1_2
cl1717119-154  PH-like superfamily
cd001551034-1266  RasGEF
cl024851034-1266  RasGEF superfamily
cd00160241-424  RhoGEF
cl02571241-424  RhoGEF superfamily
cd06224652-702  REM
cl02520652-702  REM superfamily
smart001471034-1270  RasGEF
pfam006171038-1220  RasGEF
smart00325244-425  RhoGEF
pfam00621244-425  RhoGEF
cd1328825-132  PH_Ses
smart0023324-129  PH
pfam0016924-129  PH
pfam00618647-698  RasGEF_N
cd1325818-129  PH_PLEKHJ1
smart00229938-1007  RasGEFN
cl02520938-1007  REM superfamily
cd0082125-124  PH
cd1337825-124  PH_RhoGAP2
cd1330125-128  PH1_Pleckstrin_2
cd1057323-124  PH_DAPP1
cd1327325-124  PH_SWAP-70
cd06224934-993  REM
cd1338025-124  PH_Skap1
cd1326625-128  PH_Skap_family
cd1326322-129  PH_RhoGap25-like
cd1324824-128  PH_PEPP1_2_3
cd1327242-142  PH_INPP4A_INPP4B
cd1329616-135  PH2_MyoX
cd01218431-582  PH_Phafin2-like
cl17171431-582  PH-like superfamily
cd1330817-77  PH_3BP2
cd1327625-127  PH_AtPH1
cd1326021-71  PH_RASA1
cd1325025-124  PH_ACAP
cd1329127-121  PH_ORP10_ORP11
cd1332627-107  PH_CNK_insect-like
cd1329827-131  PH1_PH_fungal
smart00229648-700  RasGEFN
cd1338125-70  PH_Skap-hom_Skap2
cd1331626-128  PH_Boi
cd0125225-70  PH_GRP1-like
cd01220474-587  PH1_FARP1-like
cd1328225-124  PH1_PLEKHH1_PLEKHH2
cd1337925-124  PH_RhoGap24
pfam00169478-583  PH
cd1327525-72  PH_M-RIP
smart00233480-584  PH
cd132157-124  PH-GRAM1_AGT26
cd13242444-581  PH_puratrophin-1
PRK08944148-179  motB


Ontology Information


   
HPRD ID4581
Molecular ClassGuanine nucleotide exchange factor
Molecular FunctionReceptor signaling complex scaffold activity (GO:0030159)
Biological ProcessApoptosis (GO:0006915)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO