Search results:


General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
LGR6 59352 leucine-rich repeat containing G protein-coupled receptor 6  1FLJ14471 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
22615920   2012Cell line : LGR6

Source : Open Biosystems

Sample Type : -

No. of Sample : -

Stage : -

Immunoblotting, cell migration assaysUp-regulation-Overexpression of wild-type LGR6 in HeLa cells leads to increased cell migration following co-treatment with R-spondin1 and Wnt3a when compared to vector control cells or cells overexpressing the loss-of-function mutant.


Gene Details



NC_000001.10 (202163118..202288889)

View Larger Image
   
Gene Type protein coding
Gene Family GPCR / Class A : Orphans
Description This gene encodes a member of the leucine-rich repeat-containing subgroup of the G protein-coupled 7-transmembrane protein superfamily. The encoded protein is a glycoprotein hormone receptor with a large N-terminal extracellular domain that contains leucine-rich repeats important for the formation of a horseshoe-shaped interaction motif for ligand binding. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]  
Chromosome 1
Location 1q32.1
Start 202163118  
End 202288889  
Strand +  
Gene Sequence

   Download   Select all

Length 125772  
OMIM ID 606653   
HGNC ID HGNC:19719   
Unigene ID Hs.497402   
Ensembl ID ENSG00000133067   
PharmGKB ID PA134927114   

mRNA Information


mRNA ID ?NM_001017403.1
Exon  
mRNA Sequence

   Download   Select all

Length  



CDS Information


   
Location
CDS Sequence

   Download   Select all

CCDS ID CCDS1424.1



Protein Information


      
Protein IDNP_001017403.1
Protein Nameleucine-rich repeat containing G protein-coupled receptor 6
Molecular Wt. (Da)0
Protein Sequence

   Download   Select all

Length 967  
Uniprot IDP61236
Ensembl Protein ID ENSP00000381818  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation405;-
SPhosphorylation457;-
SPhosphorylation318;-

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

No matching records from HPRD source could be found.

Pathway Information


No matching records could be found.

Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd00116131-392  LRR_RI
cl23707131-392  LRR_RI superfamily
cd00116230-435  LRR_RI
cd00116253-442  LRR_RI
cd0011653-271  LRR_RI
cd0011657-199  LRR_RI
cl2370757-199  LRR_RI superfamily
pfam12799352-389  LRR_4
cl19302352-389  LRR_4 superfamily
pfam12799210-251  LRR_4
pfam12799399-438  LRR_4
cl19302399-438  LRR_4 superfamily
pfam12799234-273  LRR_4
smart0001334-68  LRRNT
cl0242334-68  LRRNT superfamily
pfam1279992-131  LRR_4
cl1930292-131  LRR_4 superfamily
pfam12799138-179  LRR_4
pfam13855375-434  LRR_8
pfam1385592-150  LRR_8
pfam13855162-222  LRR_8
pfam13855210-269  LRR_8
pfam13855328-386  LRR_8
pfam13855258-314  LRR_8
PLN0011360-435  PLN00113
PLN0011371-453  PLN00113
COG488648-262  LRR
COG4886143-464  LRR
PLN0011371-441  PLN00113
pfam13855186-246  LRR_8
PLN0011360-262  PLN00113
pfam1385570-126  LRR_8
PRK15370119-368  PRK15370
pfam13855115-174  LRR_8
pfam13855138-198  LRR_8
PRK1537057-250  PRK15370
pfam13855352-410  LRR_8
PRK1537049-203  PRK15370
pfam13306201-303  LRR_5
pfam13855398-453  LRR_8
pfam13306139-283  LRR_5
PRK1538751-273  PRK15387
PLN03150372-445  PLN03150
PLN00113208-473  PLN00113
PRK15370238-438  PRK15370
PRK15370333-481  PRK15370
PLN03150392-453  PLN03150
pfam13855305-364  LRR_8
pfam1330676-212  LRR_5
COG523871-314  RNA1
PLN03210235-466  PLN03210
PLN0315071-151  PLN03150
PRK15387305-453  PRK15387
pfam13306267-335  LRR_5


Ontology Information


   
HPRD ID16497
Molecular ClassG protein coupled receptor
Molecular FunctionMolecular function unknown (GO:0005554)
Biological ProcessBiological_process unknown (GO:0000004)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO