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General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 11896626 | 2002 | Cell line : - Source : State Key Laboratory of Cancer Biology; Xijing Hospital of Digestive Diseases. Sample Type : - No. of Sample : - Stage : - | Detection of polymorphisms, Cyclin D1 genotyping. | Polymorhpism | - | Found a significantly higher frequency of CCND1 870A allele in 206 familial cases compared to 171 controls.
|
| 21036743 | 2010 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | Ggenotyping | Polymorhpism | - | Intratumoral gene expression levels of EGFR, VEGFR2 and NRP as well as polymorphisms in FCGR3A, CyclinD1 and EGFR could predict clinical outcome in mCRC patients enrolled in BOND2, independent of KRAS mutation status. FCGR3A V158F, CyclinD1 A870G and EGFR R497K polymorphisms are associated with clinical outcome in patients received combined cetuximab and bevacizumab. |
| 19901563 | 2010 | Cell line : - Source : - Sample Type : CRC tumor and Normal tissue No. of Sample : 54 CRC tumor and 40 normal tissue Stage : - | Immunohistochemistry, Protein extraction and western blotting , real-time PCR | Up-regulation | - | Co-expression of cyclinD1 and beta-catenin were positive correlation with the alteration of gankyrin expression. gankyrin played significant roles in the pathogenesis of human CRC, and might be an important therapeutic target for CRC. CRC cell lines SW620, Coca2 and Lovo and 100 CRC patient were included. |
| 20509140 | 2010 | Cell line : - Source : UK Sample Type : CRC tumor and Normal tissue No. of Sample : 206 CRC tumor and 171 Normal tissue Stage : - | - | Up-regulation | - | Dauricine down-regulated the expression of various NF-kappaB-regulated genes, including genes involved cell proliferation (cyclinD1, COX2, and c-Myc). Dauricine inhibited colon cancer cell proliferation, invasion, and induced cell apoptosis by suppressing NF-kappaB activity and the expression profile of its downstream genes. |
| 22024062 | 2011 | Cell line : - Source : - Sample Type : CRC tumor and Normal tissue No. of Sample : 65 Stage : TNM Stage IV | Immunohistochemistry, Tissue microarrays | Up-regulation | - | Aberrant expression of p53, cyclinD1, bcl-2, B-catenin, c-myc, COX-2 and nm23-H1 might attribute to the carcinogenesis of human rectal cancer. cyclinD1 and nm23-H1 might be involved in rectal cancer progression. Positive correlations of B-catenin with cyclinD1 and c-myc and of p53 with bcl-2 were found. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. [provided by RefSeq, Jul 2008] |
| Chromosome | 11 |
| Location | 11q13 |
| Start | 69641105 |
| End | 69654474 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 13370 |
| OMIM ID | 168461 |
| HGNC ID | HGNC:1582 |
| Unigene ID | Hs.523852 |
| Ensembl ID | ENSG00000110092 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_053056.2 |
|---|---|
| Exon | join(1..407,1927..2142,2728..2887,6890..7038,10014..13370) | mRNA Sequence | Download Select all |
| Length | 4304 |
CDS Information
| Location | join(210..407,1927..2142,2728..2887,6890..7038, 10014..10178) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS8191.1 |
Protein Information
| Protein ID | NP_444284.1 |
|---|---|
| Protein Name | Cyclin D1 |
| Molecular Wt. (Da) | 33598 |
| Protein Sequence | Download Select all |
| Length | 295 |
| Uniprot ID | P00352 |
| Ensembl Protein ID | ENSP00000297785 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 197 |
| S | Phosphorylation | 234 |
| S | Phosphorylation | 90 |
| T | Phosphorylation | 286 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 672 | BRCA1 | 218 | NP_009231.2 | in vitro | 9244350 |
| 801 | CALM1 | 241 | NP_008819.1 | in vivo | 9837900 |
| 1019 | CDK4 | 447 | NP_000066.1 | in vitro;in vivo | 983 790 091 503 681 000 000 000 000 000 |
| 1026 | CDKN1A | 298 | NP_510867.1 | in vitro;in vivo | 865 715 474 785 829 000 000 |
| 1499 | CTNNB1 | 286 | NP_001895.1 | in vivo | 1 183 655 517 208 330 |
| 2099 | ESR1 | 589 | NP_000116.2 | in vitro;in vivo;yeast 2-hybrid | 903 926 711 073 968 |
| 5933 | RBL1 | 312 | NP_002886.2 | in vivo | 8643455 |
| 5981 | RFC1 | 24 | NP_002904.3 | in vivo | 10353443 |
| 6774 | STAT3 | 26 | NP_644805.1 | in vivo | 11279133 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Acute myeloid leukemia | hsa05221 |
| AGE-RAGE signaling pathway in diabetic complications | hsa04933 |
| AMPK signaling pathway | hsa04152 |
| Bladder cancer | hsa05219 |
| Cell cycle | hsa04110 |
| Chronic myeloid leukemia | hsa05220 |
| Colorectal cancer | hsa05210 |
| Endometrial cancer | hsa05213 |
| Focal adhesion | hsa04510 |
| FoxO signaling pathway | hsa04068 |
| Glioma | hsa05214 |
| Hepatitis B | hsa05161 |
| Hippo signaling pathway | hsa04390 |
| HTLV-I infection | hsa05166 |
| Jak-STAT signaling pathway | hsa04630 |
| Measles | hsa05162 |
| Melanoma | hsa05218 |
| MicroRNAs in cancer | hsa05206 |
| Non-small cell lung cancer | hsa05223 |
| Oxytocin signaling pathway | hsa04921 |
| p53 signaling pathway | hsa04115 |
| Pancreatic cancer | hsa05212 |
| Pathways in cancer | hsa05200 |
| PI3K-Akt signaling pathway | hsa04151 |
| Prolactin signaling pathway | hsa04917 |
| Prostate cancer | hsa05215 |
| Proteoglycans in cancer | hsa05205 |
| Small cell lung cancer | hsa05222 |
| Thyroid cancer | hsa05216 |
| Thyroid hormone signaling pathway | hsa04919 |
| Viral carcinogenesis | hsa05203 |
| Viral myocarditis | hsa05416 |
| Wnt signaling pathway | hsa04310 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00043 | 56-131 | CYCLIN |
| cl00050 | 56-131 | CYCLIN superfamily |
| pfam00134 | 31-152 | Cyclin_N |
| smart00385 | 62-132 | CYCLIN |
| pfam02984 | 156-269 | Cyclin_C |
| cl00050 | 156-269 | CYCLIN superfamily |
| COG5024 | 31-201 | COG5024 |
Ontology Information
| HPRD ID | 1 |
|---|---|
| Molecular Class | Cell cycle control protein |
| Molecular Function | Aldehyde dehydrogenase activity (GO:0004028) |
| Biological Process | Aldehyde metabolism (GO:0006081) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P24385 | DB01169 | Arsenic trioxide | SmallMoleculeDrug |