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General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 17192048 | 2005 | Cell line : - Source : - Sample Type : CRC tumor and Normal tissue No. of Sample : - Stage : TNM Stage II | - | Down-regulation | - | Decreased or lack of Bcl-2 expression in primary CRCs may serve as a molecular biomarker of high risk of recurrence for Caucasian patients with Stage II CRCs. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Serine/threonine phosphatases / Protein phosphatase 1, regulatory subunits |
| Description | This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants, produced by alternate splicing, differ in their C-terminal ends. |
| Chromosome | 18 |
| Location | 18q21.3 |
| Start | 63123346 |
| End | 63319778 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 196433 |
| OMIM ID | 151430 |
| HGNC ID | HGNC:990 |
| Unigene ID | Hs.150749 |
| Ensembl ID | ENSG00000171791 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_000633.2 |
|---|---|
| Exon | join(399..605,827..1697,191020..196433) | mRNA Sequence | Download Select all |
| Length | 6492 |
CDS Information
| Location | join(1113..1697,191020..191154) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS11981.1 |
Protein Information
| Protein ID | NP_000624.2 |
|---|---|
| Protein Name | B-cell CLL/lymphoma 2 |
| Molecular Wt. (Da) | 26135 |
| Protein Sequence | Download Select all |
| Length | 239 |
| Uniprot ID | P10070 |
| Ensembl Protein ID | ENSP00000354586 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| T | Phosphorylation | 56 |
| T | Phosphorylation | 74 |
| T | Phosphorylation | 56 |
| T | Phosphorylation | 74 |
| S | Phosphorylation | 87 |
| S | Phosphorylation | 87 |
| S | Phosphorylation | 24 |
| S | Phosphorylation | 24 |
| S | Dephosphorylation | 87 |
| D | Proteolytic Cleavage | 34 |
| D | Proteolytic Cleavage | 34 |
| T | Phosphorylation | 69 |
| S | Phosphorylation | 70 |
| S | Phosphorylation | 87 |
| T | Phosphorylation | 69 |
| S | Phosphorylation | 70 |
| S | Phosphorylation | 87 |
| S | Phosphorylation | 70 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 488 | ATP2A2 | 161 | NP_733765.1 | in vivo | 9788433 |
| 1017 | CDK2 | 310 | NP_001789.2 | in vivo | 15619620 |
| 1432 | MAPK14 | 2619 | NP_001306.1 | in vivo | 11495898 |
| 3164 | NR4A1 | 744 | NP_002126.2 | in vitro;in vivo;yeast 2-hybrid | 1 498 022 018 835 030 |
| 3303 | HSPA1A | 774 | NP_005336.3 | in vivo | 10354271 |
| 3708 | ITPR1 | 925 | Q14643 | in vitro | 15613488 |
| 4609 | MYC | 1818 | NP_002458.2 | in vitro | 15210690 |
| 5371 | PML | 23 | NP_150241.2 | in vitro | 15231068 |
| 5530 | PPP3CA | 234 | NP_000935.1 | in vivo | 91 094 917 593 193 |
| 5566 | PRKACA | 3382 | NP_002721.1 | in vitro | 1 115 820 479 294 240 000 000 |
| 5595 | MAPK3 | 3479 | NP_002737.2 | in vitro | 10677502 |
| 5663 | PSEN1 | 87 | NP_000012.1 | in vitro;in vivo;yeast 2-hybrid | 10521466 |
| 5829 | PXN | 3937 | BAA18998.1 | in vitro | 10417825 |
| 6647 | SOD1 | 937 | NP_000445.1 | in vitro;in vivo | 15233914 |
| 7009 | TMBIM6 | 2851 | NP_001092046.1 | in vivo | 9660918 |
| 54205 | CYCS | 479 | NP_061820.1 | in vivo | 10622714 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Adrenergic signaling in cardiomyocytes | hsa04261 |
| AGE-RAGE signaling pathway in diabetic complications | hsa04933 |
| Amyotrophic lateral sclerosis (ALS) | hsa05014 |
| Apoptosis | hsa04210 |
| Cholinergic synapse | hsa04725 |
| Colorectal cancer | hsa05210 |
| Epstein-Barr virus infection | hsa05169 |
| Focal adhesion | hsa04510 |
| Hepatitis B | hsa05161 |
| HIF-1 signaling pathway | hsa04066 |
| Jak-STAT signaling pathway | hsa04630 |
| MicroRNAs in cancer | hsa05206 |
| Neurotrophin signaling pathway | hsa04722 |
| NF-kappa B signaling pathway | hsa04064 |
| Pathways in cancer | hsa05200 |
| PI3K-Akt signaling pathway | hsa04151 |
| Prostate cancer | hsa05215 |
| Protein processing in endoplasmic reticulum | hsa04141 |
| Small cell lung cancer | hsa05222 |
| Sphingolipid signaling pathway | hsa04071 |
| Toxoplasmosis | hsa05145 |
| Tuberculosis | hsa05152 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd06845 | 86-201 | Bcl-2_like |
| cl02575 | 86-201 | Bcl-2_like superfamily |
| smart00337 | 97-195 | BCL |
| pfam00452 | 97-195 | Bcl-2 |
| smart00265 | Jul-33 | BH4 |
| cl23051 | Jul-33 | BH4 superfamily |
| pfam02180 | Jul-33 | BH4 |
| cl23112 | Jul-33 | BH4 superfamily |
| TIGR00865 | 1-239 | bcl-2 |
Ontology Information
| HPRD ID | 5093 |
|---|---|
| Molecular Class | Adapter molecule |
| Molecular Function | GTPase activity (GO:0003924) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P10415 | DB01050 | Ibuprofen | SmallMoleculeDrug |
| P10415 | DB01229 | Paclitaxel | SmallMoleculeDrug |
| P10415 | DB01248 | Docetaxel | SmallMoleculeDrug |
| P10415 | DB01367 | Rasagiline | SmallMoleculeDrug |