Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| REL | 5966 | v-rel avian reticuloendotheliosis viral oncogene homolog | 2 | I-Rel, c-Rel |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 19621336 | 2009 | Cell line : HT 29,
LoVo, SW480, SW620, Caco 2 Source : Daping Hospital, Third Military Medical University, Chongqing, China. Cell Bank of Academia Sinica. Sample Type : CRC tumor No. of Sample : 64 Stage : Duke stage I-IV | Methylation-specific PCR, Immunohistochemistry, western blotting,Chromatin immunoprecipitation, Electrophoretic gel mobility shift | Up-regulation | - | c-Rel acts as a transcriptional repressor of EPHB2 and plays an active role in EPHB2 down-regulation in colorectal cancers. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes a protein that belongs to the Rel homology domain/immunoglobulin-like fold, plexin, transcription factor (RHD/IPT) family. Members of this family regulate genes involved in apoptosis, inflammation, the immune response, and oncogenic processes. This proto-oncogene plays a role in the survival and proliferation of B lymphocytes. Mutation or amplification of this gene is associated with B-cell lymphomas, including Hodgkin's lymphoma. Single nucleotide polymorphisms in this gene are associated with susceptibility to ulcerative colitis and rheumatoid arthritis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014] |
| Chromosome | 2 |
| Location | 2p13-p12 |
| Start | 61108709 |
| End | 61171410 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 62702 |
| OMIM ID | 164910 |
| HGNC ID | HGNC:9954 |
| Unigene ID | Hs.631886 |
| Ensembl ID | ENSG00000162924 |
| PharmGKB ID | PA34321 |
mRNA Information
| mRNA ID | ?NM_001291746.1 |
|---|---|
| Exon | join(1..401,18730..19418,22401..22493,26562..26692, 28276..28350,29428..31967) | mRNA Sequence | Download Select all |
| Length | 3939 |
Protein Information
| Protein ID | NP_001278675.1 |
|---|---|
| Protein Name | v-rel avian reticuloendotheliosis viral oncogene homolog |
| Molecular Wt. (Da) | 59779 |
| Protein Sequence | Download Select all |
| Length | 619 |
| Uniprot ID | Q13444 |
| Ensembl Protein ID | ENSP00000271836 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 801 | CALM1 | 241 | NP_008819.1 | in vitro | 12556500 |
| 898 | CCNE1 | 455 | NP_001229.1 | in vitro | 9731206 |
| 1326 | MAP3K8 | 1863 | NP_005195.2 | in vitro;in vivo | 995 043 014 743 216 |
| 4793 | NFKBIB | 7260 | NP_002494.2 | in vitro;in vivo | 147 432 169 135 156 |
| 4851 | NOTCH1 | 1827 | NP_060087.3 | in vivo | 16319921 |
| 79155 | TNIP2 | 18207 | NP_077285.3 | in vitro | 14743216 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Ras signaling pathway | hsa04014 |
| Transcriptional misregulation in cancer | hsa05202 |
| Viral carcinogenesis | hsa05203 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd07933 | 8-179 | RHD-n_c-Rel |
| cl08275 | 8-179 | RHD-n superfamily |
| cd01177 | 186-281 | IPT_NFkappaB |
| cl15674 | 186-281 | IPT superfamily |
| pfam00554 | 10-178 | RHD |
| cd07827 | 8-179 | RHD-n |
| cd07885 | 8-179 | RHD-n_RelA |
| cd07887 | 8-179 | RHD-n_Dorsal_Dif |
| cd07883 | 8-179 | RHD-n_NFkB |
| cd07886 | 8-179 | RHD-n_RelB |
| cd07934 | 8-179 | RHD-n_NFkB2 |
| cd07935 | 8-179 | RHD-n_NFkB1 |
| cd00602 | 186-281 | IPT_TF |
| cd07884 | 8-177 | RHD-n_Relish |
| smart00429 | 185-280 | IPT |
| cd00102 | 186-281 | IPT |
| cd01178 | 188-281 | IPT_NFAT |
| cd07927 | Aug-82 | RHD-n_NFAT_like |
Ontology Information
| HPRD ID | 4523 |
|---|---|
| Molecular Class | Transcription factor |
| Molecular Function | Cell adhesion molecule activity (GO:0005194) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.