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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| BCL2L1 | 598 | BCL2-like 1 | 20 | BCLX; BCL2L; BCLXL; BCLXS; Bcl-X; bcl-xL; bcl-xS; PPP1R52; BCL-XL/S |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 17848589 | 2007 | Cell line : - Source : Tumor Bank Network established at the Centro Nacional de Investigaciones Oncol?gicas (CNIO). Sample Type : - No. of Sample : - Stage : - | Antibody Microarrays,Protein Labeling and Microarray Assay,Tissue Microarray Design and Immunohistochemistry | Down-regulation | 0.557 | - |
| 22009326 | 2012 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | - | Up-regulation | - | BCL2L1 has a functional role in colorectal cancer and its protein expression is associated with chromosome 20q gain. Down-modulation of BCL2L1 inhibited cell viability and anchorage-independent growth of CRC cells, while invasion was not affected. BCL2L1 DNA copy number and protein expression were increased in CRCs compared to adenomas. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Serine/threonine phosphatases / Protein phosphatase 1, regulatory subunits |
| Description | The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. The longer isoform acts as an apoptotic inhibitor and the shorter form acts as an apoptotic activator. [provided by RefSeq, Jul 2008] |
| Chromosome | 20 |
| Location | 20q11.21 |
| Start | 31664452 |
| End | 31723964 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 59513 |
| OMIM ID | 600039 |
| HGNC ID | HGNC:992 |
| Unigene ID | Hs.516966 |
| Ensembl ID | ENSG00000171552 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | XM_005260487.3 |
|---|---|
| Exon | join(1..101,1635..2310,57879..59513) | mRNA Sequence | Download Select all |
| Length | 2386 |
CDS Information
| Location | join(1747..2121,57879..58016) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS13188.1 |
Protein Information
| Protein ID | NP_001182.1 |
|---|---|
| Protein Name | BCL2-like 1 |
| Molecular Wt. (Da) | 18763 |
| Protein Sequence | Download Select all |
| Length | 170 |
| Uniprot ID | P05091 |
| Ensembl Protein ID | ENSP00000261733 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| E | Proteolytic Cleavage | 42 |
| E | Proteolytic Cleavage | 42 |
| D | Proteolytic Cleavage | 61 |
| D | Proteolytic Cleavage | 61 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 596 | BCL2 | 1045 | NP_000624.2 | in vitro | 11583631 |
| 637 | BID | 3590 | NP_932070.1 | yeast 2-hybrid | 1 557 433 515 694 340 |
| 1409 | CRYAA | 427 | NP_000385.1 | in vitro;in vivo | 14752512 |
| 1410 | CRYAB | 428 | NP_001876.1 | in vitro;in vivo | 14752512 |
| 3667 | IRS1 | 943 | NP_005535.1 | in vivo | 10679027 |
| 5599 | MAPK8 | 3100 | NP_620637.1 | in vitro | 15733859 |
| 5663 | PSEN1 | 87 | NP_000012.1 | in vivo;yeast 2-hybrid | 10446169 |
| 5883 | RAD9A | 4788 | NP_004575.1 | in vivo;yeast 2-hybrid | 10620799 |
| 6622 | SNCA | 1227 | NP_000336.1 | in vivo | 11742726 |
| 7157 | TP53 | 1859 | NP_000537.3 | in vitro;in vivo | 1 266 744 316 151 010 |
| 10134 | BCAP31 | 2319 | NP_001132929.1 | in vitro;in vivo | 9334338 |
| 54205 | CYCS | 479 | NP_061820.1 | in vivo | 9192670 |
| 83596 | BCL2L12 | 16543 | NP_619580.1 | in vitro | 11283018 |
| 90427 | BMF | 5881 | NP_277038.1 | in vitro | 1 569 434 016 697 950 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Amyotrophic lateral sclerosis (ALS) | hsa05014 |
| Apoptosis | hsa04210 |
| Chronic myeloid leukemia | hsa05220 |
| HTLV-I infection | hsa05166 |
| Jak-STAT signaling pathway | hsa04630 |
| NF-kappa B signaling pathway | hsa04064 |
| Pancreatic cancer | hsa05212 |
| Pathways in cancer | hsa05200 |
| PI3K-Akt signaling pathway | hsa04151 |
| Ras signaling pathway | hsa04014 |
| Small cell lung cancer | hsa05222 |
| Toxoplasmosis | hsa05145 |
| Transcriptional misregulation in cancer | hsa05202 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd06845 | 81-194 | Bcl-2_like |
| cl02575 | 81-194 | Bcl-2_like superfamily |
| pfam00452 | 90-188 | Bcl-2 |
| smart00337 | 90-188 | BCL |
| pfam02180 | 27-Jan | BH4 |
| cl23112 | 27-Jan | BH4 superfamily |
| smart00265 | 27-Jan | BH4 |
| cl23051 | 27-Jan | BH4 superfamily |
| PHA03159 | 136-230 | PHA03159 |
| TIGR00865 | 1-233 | bcl-2 |
Ontology Information
| HPRD ID | 3 |
|---|---|
| Molecular Class | Adapter molecule |
| Molecular Function | Catalytic activity (GO:0003824) |
| Biological Process | Metabolism (GO:0008152); Energy pathways (GO:0006091) |
Drug Information
No matching records could be found.