Search results:


General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
RFC3 5983 replication factor C (activator 1) 3, 38kDa  13RFC38, MGC5276 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
20573375   2010Cell line : -

Source : -

Sample Type : CRC tumor and normal tissues

No. of Sample : 35 CRC with MSI-H, 20 CRC with MSI-L, and 45 CRC

Stage : -

SSCPFrameshift Mutation-RFC3 mutation and loss of RFC3 expression occur in large fractions of GC and CRC and suggest that these alterations may contribute to the cancer pathogenesis by deregulating DNA repair and replication.


Gene Details



NC_000013.10 (34392206..34540695)

View Larger Image
   
Gene Type protein coding
Gene Family ATPases / AAA-type
Description The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1, is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kDa. This gene encodes the 38 kDa subunit. This subunit is essential for the interaction between the 140 kDa subunit and the core complex that consists of the 36, 37, and 40 kDa subunits. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]  
Chromosome 13
Location 13q13.2
Start 34392206  
End 34540695  
Strand +  
Gene Sequence

   Download   Select all

Length 148490  
OMIM ID 600405   
HGNC ID HGNC:9971   
Unigene ID Hs.115474   
Ensembl ID ENSG00000133119   
PharmGKB ID PA34340   

mRNA Information


mRNA ID ?NM_002915.3
Exon join(1..217,3084..3221,5869..5936,7741..7838,11788..11969, 12671..12807,13208..13306,17100..17169,155869..155898)  
mRNA Sequence

   Download   Select all

Length 1039  



CDS Information


   
Location 131..1024
CDS Sequence

   Download   Select all

CCDS ID CCDS45025.1



Protein Information


      
Protein IDNP_002906.1
Protein Namereplication factor C (activator 1) 3, 38kDa
Molecular Wt. (Da)46271
Protein Sequence

   Download   Select all

Length 356  
Uniprot IDO15164
Ensembl Protein ID ENSP00000340507  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation125;-
SPhosphorylation125;-
KAcetylation20
KAcetylation20
YPhosphorylation60
YPhosphorylation60

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                              
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
5981RFC124NP_002904.3in vitro;in vivo94   887   388   692   848   
5984RFC422NP_002907.1in vitro;in vivo94   887   388   692   848   


Pathway Information


                  
Pathway Name Pathway ID
DNA replication hsa03030
Mismatch repair hsa03430
Nucleotide excision repair hsa03420


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd0000921-179  AAA
cl2145521-179  P-loop_NTPase superfamily
pfam08542250-339  Rep_fac_C
cl16006250-339  Rep_fac_C superfamily
pfam1340137-164  AAA_22
PRK124023-339  PRK12402
PRK004403-345  rfc
PLN030254-205  PLN03025
PRK0413293-339  PRK04132
PHA025443-204  44
COG0470157-348  HolB
COG28127-227  DnaX
PRK149627-231  PRK14962
TIGR0067824-192  holB
PRK149617-231  PRK14961
pfam1317725-188  DNA_pol3_delta2
PRK149707-272  PRK14970
PRK07940108-216  PRK07940
PRK149577-227  PRK14957
PRK14971129-272  PRK14971
PRK14953129-227  PRK14953
smart0038237-190  AAA
PRK149607-227  PRK14960
PRK149567-231  PRK14956
PRK149647-231  PRK14964
PRK05564128-192  PRK05564
PRK0570722-191  PRK05707
PRK086917-319  PRK08691
PRK06090108-190  PRK06090
PRK0630587-226  PRK06305
PRK04132Apr-48  PRK04132
PRK0664539-234  PRK06645
PRK14963130-222  PRK14963
PRK07132121-192  PRK07132
pfam032153-169  Rad17
PRK14969129-227  PRK14969
PRK09112123-229  PRK09112
PRK071334-231  PRK07133
TIGR006023-164  rad24
TIGR02397129-301  dnaX_nterm
PRK149507-227  PRK14950
PRK06871108-256  PRK06871
TIGR029288-148  TIGR02928
PRK07399124-206  PRK07399
PRK05917129-228  PRK05917
PRK07276107-178  PRK07276


Ontology Information


   
HPRD ID6322
Molecular ClassDNA binding protein
Molecular FunctionCatalytic activity (GO:0003824)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO