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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
RFC4 5984 replication factor C (activator 1) 4, 37kDa  3A1, RFC37 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
25407051   2014Cell line : -

Source : -

Sample Type : CRC Tumor and normal tissue

No. of Sample : 30

Stage : -

-Up-regulation-RFC4 is frequently overexpressed in CRC, and is associated with tumor progression and worse survival outcome.


Gene Details



NC_000003.11 (186507681..186524484, complement)

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Gene Type protein coding
Gene Family ATPases / AAA-type
Description The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1, is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kD. This gene encodes the 37 kD subunit. This subunit forms a core complex with the 36 and 40 kDa subunits. The core complex possesses DNA-dependent ATPase activity, which was found to be stimulated by PCNA in an in vitro system. Alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]  
Chromosome 3
Location 3q27
Start 186507681  
End 186524484  
Strand -  
Gene Sequence

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Length 16804  
OMIM ID 102577   
HGNC ID HGNC:9972   
Unigene ID Hs.732098   
Ensembl ID ENSG00000163918   
PharmGKB ID PA34341   

mRNA Information


mRNA ID ?NM_002916.3
Exon complement(<16799..>16804)  
mRNA Sequence

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Length 1905  



CDS Information


   
Location 40..1263
CDS Sequence

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CCDS ID CCDS3283.1



Protein Information


      
Protein IDNP_002907.1
Protein Namereplication factor C (activator 1) 4, 37kDa
Molecular Wt. (Da)24251
Protein Sequence

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Length 363  
Uniprot IDO43603
Ensembl Protein ID ENSP00000329684  



Post-translational Modification Information (Source : HPRD)


Residue Type site
KAcetylation13
KAcetylation13
KAcetylation6
KAcetylation6
TPhosphorylation8
SPhosphorylation11
TPhosphorylation12
TPhosphorylation17
TPhosphorylation8
SPhosphorylation11
TPhosphorylation12
TPhosphorylation17

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

               
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
5884RAD179124NP_579917.1in vitro11907025   


Pathway Information


                  
Pathway Name Pathway ID
DNA replication hsa03030
Mismatch repair hsa03430
Nucleotide excision repair hsa03420


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd0000955-201  AAA
cl2145555-201  P-loop_NTPase superfamily
pfam08542267-355  Rep_fac_C
cl16006267-355  Rep_fac_C superfamily
pfam0000474-202  AAA
pfam0549645-95  RuvB_N
pfam1340174-179  AAA_22
pfam1319151-179  AAA_16
pfam1360478-162  AAA_30
pfam1348175-169  AAA_25
PRK0044039-353  rfc
PLN0302538-353  PLN03025
PRK1240240-354  PRK12402
PRK0413285-353  PRK04132
PHA0254440-356  44
PRK0419537-259  PRK04195
TIGR0239743-362  dnaX_nterm
PRK1496243-316  PRK14962
COG281243-339  DnaX
PRK1495338-314  PRK14953
PRK0713340-316  PRK07133
PRK1334242-267  PRK13342
PRK1496342-310  PRK14963
COG225639-267  RarA
PRK1497043-269  PRK14970
COG0470171-351  HolB
PRK0589642-335  PRK05896
PRK1495643-255  PRK14956
PRK0664743-307  PRK06647
PRK0630543-315  PRK06305
TIGR0067862-241  holB
PRK1496543-315  PRK14965
PRK0556343-310  PRK05563
PRK1334130-276  PRK13341
PRK1496443-269  PRK14964
PRK1494843-270  PRK14948
PRK1495939-300  PRK14959
PRK1495243-321  PRK14952
PRK0845143-296  PRK08451
PRK1495043-321  PRK14950
PRK1496143-274  PRK14961
PRK1495843-338  PRK14958
PRK1495743-296  PRK14957
pfam1317755-203  DNA_pol3_delta2
PRK0739950-247  PRK07399
PRK0664531-274  PRK06645
PRK1497143-264  PRK14971
PRK0869143-255  PRK08691
PRK0413239-139  PRK04132
PRK1496943-269  PRK14969
PRK0911256-328  PRK09112
pfam0321539-273  Rad17
PRK1495543-320  PRK14955
PRK1496043-348  PRK14960
smart0038273-199  AAA
TIGR0060239-276  rad24
PRK1495443-262  PRK14954
TIGR0290239-116  spore_lonB
PRK1495143-255  PRK14951
COG147456-329  CDC6
COG046450-236  SpoVK
PRK05564145-236  PRK05564
PRK07471102-245  PRK07471
PRK0805855-213  PRK08058
PRK0008045-95  ruvB
COG1466145-310  HolA
PRK0869971-201  PRK08699
PRK0700343-267  PRK07003
PRK0876974-200  PRK08769
PRK0041156-248  cdc6
TIGR0292856-248  TIGR02928
PRK05917143-264  PRK05917
COG225545-95  RuvB
PRK07993115-194  PRK07993
PRK0570774-211  PRK05707
TIGR0076357-232  lon
COG122350-155  COG1223
PRK0776443-163  PRK07764
PRK07132145-219  PRK07132
PRK06090144-201  PRK06090
COG071473-173  MoxR
PRK06964145-197  PRK06964
pfam1308675-98  AAA_11
CHL0017656-92  ftsH
TIGR0063555-261  ruvB
TIGR0368974-155  pup_AAA
pfam0984874-152  DUF2075
PRK0683556-95  PRK06835
COG046657-232  Lon
PRK06871115-194  PRK06871
COG148473-95  DnaC


Ontology Information


   
HPRD ID7062
Molecular ClassDNA binding protein
Molecular FunctionHydrolase activity (GO:0016787)
Biological ProcessMetabolism (GO:0008152)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO