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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
RGS12 6002 regulator of G-protein signaling 12  4- 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
21209843   2011Cell line : -

Source : LIM colorectal cancer cell lines established from tumour biopsies at the Ludwig Institute for Cancer Research (LICR) Melbourne Branch

Sample Type : CRC Tumor

No. of Sample : -

Stage : -

Immunoprecipitation, Western Blotting Mutation--


Gene Details



NC_000004.11 (3315874..3441640)

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Gene Type protein coding
Gene Family Regulators of G-protein signaling
Description This gene encodes a member of the 'regulator of G protein signaling' (RGS) gene family. The encoded protein may function as a guanosine triphosphatase (GTPase)-activating protein as well as a transcriptional repressor. This protein may play a role in tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described but their biological nature has not been determined. [provided by RefSeq, Jul 2008]  
Chromosome 4
Location 4p16.3
Start 3315874  
End 3441640  
Strand +  
Gene Sequence

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Length 125767  
OMIM ID 602512   
HGNC ID HGNC:9994   
Unigene ID Hs.527061   
Ensembl ID ENSG00000159788   
PharmGKB ID PA34364   

mRNA Information


mRNA ID ?NM_002926.3
Exon join(1..122,23093..25074,49960..50076,93439..93460, 121095..121264,121775..121867,123001..123144, 123936..124115,124411..124564,127665..127741, 129399..129593,129928..130001,130538..130664, 132487..132583,135113..135192,135581..135734, 137430..137978,146478..146936)  
mRNA Sequence

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Length 4796  



CDS Information


   
Location224..4567
CDS Sequence

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CCDS ID CCDS3366.1



Protein Information


      
Protein IDNP_002917.1
Protein Nameregulator of G-protein signaling 12
Molecular Wt. (Da)22618
Protein Sequence

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Length 1447  
Uniprot IDO00748
Ensembl Protein ID ENSP00000394452  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation940;-
SPhosphorylation934;-
SPhosphorylation292;-
SPhosphorylation286;-
SPhosphorylation284;-
SPhosphorylation278;-
SPhosphorylation139;-
SPhosphorylation133;-
SPhosphorylation338;-
SPhosphorylation332;-
SPhosphorylation940;-
SPhosphorylation934;-
SPhosphorylation874
SPhosphorylation889
SPhosphorylation226
SPhosphorylation241
SPhosphorylation218
SPhosphorylation233
SPhosphorylation73
SPhosphorylation88
SPhosphorylation272
SPhosphorylation287
SPhosphorylation874
SPhosphorylation889

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                                      
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
369ARAF2405NP_001645.1in vivo;yeast 2-hybrid17380122   
774CACNA1B3005NP_000709.1in vivo11130074   
2770GNAI1756NP_002060.4in vitro;yeast 2-hybrid11387333   
2771GNAI2764NP_002061.1in vitro;yeast 2-hybrid11387333   
2773GNAI3765NP_006487.1in vitro;yeast 2-hybrid11387333   
3265HRAS1813NP_005334.1in vivo17380122   
3579CXCR2907NP_001548.1in vitro;yeast 2-hybrid9651375   
4887NPY2R1216NP_000901.1in vitro9651375   
5331PLCB32577NP_000923.1in vitro9651375   
5605MAP2K23164NP_109587.1in vivo;yeast 2-hybrid17380122   


Pathway Information


No matching records could be found.

Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd13162228-359  PTB_RGS12
cl17171228-359  PH-like superfamily
cd08742716-830  RGS_RGS12
cl02565716-830  RGS superfamily
cd01817963-1035  RGS12_RBD
cl00155963-1035  UBQ superfamily
cd0099220-96  PDZ_signaling
cl0011720-96  PDZ superfamily
cd08706716-830  RGS_R12-like
cd08743706-834  RGS_RGS14
pfam00615715-831  RGS
cd08741716-828  RGS_RGS10
smart00315715-831  RGS
cd08705708-830  RGS_R7-like
cd07440720-830  RGS
cd08740708-835  RGS_RGS11
cd08739708-830  RGS_RGS9
pfam02196962-1032  RBD
cd08718712-829  RGS_RZ-like
cd08737707-833  RGS_RGS6
cd08745712-829  RGS_RGS19
cd08746658-830  RGS_RGS20
cd01760963-1032  RBD
cd08710716-830  RGS_RGS16
cd08714716-830  RGS_RGS4
cd08713717-830  RGS_RGS3
smart00455963-1032  RBD
cd08744712-829  RGS_RGS17
cd08717716-830  RGS_RGS5
cd08738708-830  RGS_RGS7
cd08715716-828  RGS_RGS1
cd08709716-830  RGS_RGS2
smart00462228-374  PTB
pfam021961034-1104  RBD
cl001551034-1104  UBQ superfamily
smart004551035-1104  RBD
cd08711712-830  RGS_RGS8
cd08712716-828  RGS_RGS18
cd08723719-830  RGS_RGS21
cd08716716-830  RGS_RGS13
smart0022819-95  PDZ
cd00934230-359  PTB
pfam0059527-96  PDZ
cd0013631-89  PDZ
cd08707719-830  RGS_Axin
cd08719720-828  RGS_SNX13
cd13158224-340  PTB_APPL
pfam021881188-1209  GoLoco
cl235221188-1209  GoLoco superfamily
cd0098847-84  PDZ_CTP_protease
cd08721728-828  RGS_AKAP2_2
cd08708717-828  RGS_FLBA
cd08725720-814  RGS_RGS22_4
pfam00640232-345  PID
smart003901188-1209  GoLoco
cl234061188-1209  GoLoco superfamily
cd0098933-86  PDZ_metalloprotease
cd08720719-830  RGS_SNX25
cd08724721-828  RGS_GRK-like
cd08734729-824  RGS-like_1
cd0099032-83  PDZ_glycyl_aminopeptidase
cd0098747-86  PDZ_serine_protease
cd08726716-790  RGS_RGS22_3
cd13161234-359  PTB_TK_HMTK
cd00196965-1026  UBQ
COG079347-84  CtpA
TIGR0022547-86  prc
PHA033071216-1445  PHA03307


Ontology Information


   
HPRD ID3643
Molecular ClassGTPase activating protein
Molecular FunctionReceptor activity (GO:0004872)
Biological ProcessSignal transduction (GO:0007165); Cell communication (GO:0007154)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO