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General Information
- Evidence
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- Enzyme
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- Domain
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 17129358 | 2007 | Cell line : - Source : Gunma University and Maebashi Red Cross Hospitals, Japan. Sample Type : CRC tumor No. of Sample : 127 Stage : TNM Stage I-III | real time RT-PCR,Immunohistochemistry | Up-regulation | - | B9L may play an important role in tumorigenesis induced by aberrant activation of Wnt signaling and may act as a key protein in the progressive dysplasia of adenoma. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | BCL9 is associated with B-cell acute lymphoblastic leukemia. It may be a target of translocation in B-cell malignancies with abnormalities of 1q21. Its function is unknown. The overexpression of BCL9 may be of pathogenic significance in B-cell malignancies. [provided by RefSeq, Jul 2008] |
| Chromosome | 1 |
| Location | 1q21 |
| Start | 147013222 |
| End | 147098022 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 84801 |
| OMIM ID | 602597 |
| HGNC ID | HGNC:1008 |
| Unigene ID | Hs.415209 |
| Ensembl ID | ENSG00000116128 |
| PharmGKB ID | PA25318 |
mRNA Information
| mRNA ID | XM_005277417.2 |
|---|---|
| Exon | join(1..274,63377..63511,65384..65466,70178..70489, 71483..71799,73027..73216,74403..74502,77416..79657, 80871..81131,82478..84816) | mRNA Sequence | Download Select all |
| Length | 6253 |
Protein Information
| Protein ID | XP_005277474.1 |
|---|---|
| Protein Name | B-cell CLL/lymphoma 9 |
| Molecular Wt. (Da) | 147890 |
| Protein Sequence | Download Select all |
| Length | 1414 |
| Uniprot ID | P09237 |
| Ensembl Protein ID | ENSP00000260227 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| T | Phosphorylation | 315 |
| S | Phosphorylation | 687 |
| S | Phosphorylation | 687;- |
| S | Phosphorylation | 318;- |
| T | Phosphorylation | 155 |
| T | Phosphorylation | 172 |
| S | Phosphorylation | 157 |
| S | Phosphorylation | 689 |
| S | Phosphorylation | 288 |
| T | Phosphorylation | 308 |
| S | Phosphorylation | 352 |
| S | Phosphorylation | 66 |
| S | Phosphorylation | 104 |
| S | Phosphorylation | 291 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1499 | CTNNB1 | 286 | NP_001895.1 | in vivo;yeast 2-hybrid | 15294866 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam11502 | 350-389 | BCL9 |
| cl13019 | 350-389 | BCL9 superfamily |
| PHA03247 | 571-1186 | PHA03247 |
| PHA03247 | 908-1336 | PHA03247 |
| PHA03247 | 918-1410 | PHA03247 |
| pfam09770 | 1172-1404 | PAT1 |
| pfam06070 | 783-1100 | Herpes_UL32 |
| PRK12323 | 889-1125 | PRK12323 |
| pfam09770 | 882-1155 | PAT1 |
| pfam03154 | 849-1181 | Atrophin-1 |
| PHA03247 | 506-1038 | PHA03247 |
| pfam03154 | 819-1108 | Atrophin-1 |
| pfam03154 | 873-1201 | Atrophin-1 |
| pfam09770 | 984-1187 | PAT1 |
| PRK14959 | 878-1002 | PRK14959 |
| PLN02217 | 886-992 | PLN02217 |
| PRK14951 | 893-1005 | PRK14951 |
| PHA03247 | 865-999 | PHA03247 |
| PRK12323 | 886-1080 | PRK12323 |
| PRK06975 | 896-960 | PRK06975 |
| PRK14951 | 877-998 | PRK14951 |
| PRK14971 | 906-1024 | PRK14971 |
| PRK08691 | 883-1048 | PRK08691 |
| pfam03154 | 752-1055 | Atrophin-1 |
| pfam09770 | 816-953 | PAT1 |
| pfam04652 | 900-1017 | DUF605 |
Ontology Information
| HPRD ID | 385 |
|---|---|
| Molecular Class | Unclassified |
| Molecular Function | Metallopeptidase activity (GO:0008237) |
| Biological Process | Protein metabolism (GO:0019538) |
Drug Information
No matching records could be found.