Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| ROCK1 | 6093 | Rho-associated, coiled-coil containing protein kinase 1 | 18 | p160ROCK |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23328676 | 2013 | Cell line : - Source : - Sample Type : CRC tumor No. of Sample : 85 CRC and 178 controls Stage : - | Immunohistochemistry | Polymorhpism | - | ROCK1 and ROCK2 genes might be a risk factor for CRC development and that genetic polymorphisms in these genes may modify individual susceptibility to CRC in the Turkish population. |
| 25820997 | 2015 | Cell line : - Source : National Taiwan University Hospital. Sample Type : CRC tumor No. of Sample : 101 Stage : - | real time RT-PCR, Invitro migration assay, Invasion assay | Up-regulation | - | Clinically, ROCK1 and CDCP1 mRNA expression exhibited a strong positive correlation in CRC patient samples. |
| 25987767 | 2015 | Cell line : HCT116, HT29,SW620 Source : Second Affiliated Hospital of Henan University of Traditional Chinese Medicine (Zhengzhou, China). Sample Type : CRC tumor and adjecent normal tissue No. of Sample : 68 Stage : - | real time RT-PCR, Western blotting | Up-regulation | - | ROCK1 protein was significantly increased in CRC compared to normal tissues . |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Pleckstrin homology (PH) domain containing |
| Description | This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. A pseudogene, related to this gene, is also located on chromosome 18. [provided by RefSeq, Aug 2015] |
| Chromosome | 18 |
| Location | 18q11.2 |
| Start | 18529701 |
| End | 18691812 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 162112 |
| OMIM ID | 601702 |
| HGNC ID | HGNC:10251 |
| Unigene ID | Hs.306307 |
| Ensembl ID | ENSG00000067900 |
| PharmGKB ID | PA34623 |
mRNA Information
| mRNA ID | ?NM_005406.2 |
|---|---|
| Exon | join(1..1034,41239..41320,61972..62072,62623..62760, 66385..66560,67666..67750,69143..69287,69617..69755, 72289..72380,82917..83076,88172..88232,91613..91701, 96373..96421,103658..103793,105062..105153,105255..105501, 118915..119021,120526..120676,124742..124902, 127317..127501,129020..129089,131848..131942, 141339..141504,142644..142737,142992..143080, 143912..144100,144776..144935,151646..151716, 151924..152012,156607..156685,156808..157069, 158067..158274,160465..162112) | mRNA Sequence | Download Select all |
| Length | 6650 |
Protein Information
| Protein ID | NP_005397.1 |
|---|---|
| Protein Name | Rho-associated, coiled-coil containing protein kinase 1 |
| Molecular Wt. (Da) | 58844 |
| Protein Sequence | Download Select all |
| Length | 1354 |
| Uniprot ID | Q92820 |
| Ensembl Protein ID | ENSP00000260118 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| T | Phosphorylation | 1180;- |
| S | Phosphorylation | 1098 |
| S | Phosphorylation | 1100 |
| S | Phosphorylation | 1102 |
| T | Phosphorylation | 1101 |
| S | Acetylation | 2 |
| K | Acetylation | 647 |
| K | Acetylation | 718 |
| S | Phosphorylation | 1105 |
| T | Phosphorylation | 455 |
| S | Phosphorylation | 456 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 118 | ADD1 | 36 | NP_054908.2 | in vivo | 10209029 |
| 387 | RHOA | 1323 | NP_001655.1 | in vitro;yeast 2-hybrid | 8798490 |
| 389 | RHOC | 1322 | NP_786886.1 | in vivo | 8816443 |
| 993 | CDC25A | 305 | NP_001780.2 | in vitro;in vivo | 14657354 |
| 1674 | DES | 514 | NP_001918.3 | in vitro;in vivo | 10574968 |
| 1808 | DPYSL2 | 3914 | NP_001377.1 | in vitro;in vivo | 1 248 261 010 818 090 |
| 2670 | GFAP | 675 | NP_002046.1 | in vitro;in vivo | 9 099 667 215 523 670 000 000 000 000 |
| 3984 | LIMK1 | 3210 | NP_002305.1 | in vitro;in vivo | 10 436 159 106 523 500 000 000 000 000 000 |
| 3985 | LIMK2 | 3585 | AAH13051.1 | in vitro;in vivo | 1 101 804 211 340 060 |
| 4478 | MSN | 2399 | NP_002435.1 | in vitro | 95 164 639 856 983 |
| 4659 | PPP1R12A | 3606 | NP_002471.1 | in vitro;in vivo | 93 546 611 260 088 800 000 000 000 000 000 000 000 000 000 000 |
| 5217 | PFN2 | 1451 | NP_444252.1 | in vitro;in vivo | 14517206 |
| 5962 | RDX | 1534 | NP_002897.1 | in vitro | 9456324 |
| 7430 | EZR | 475 | NP_003370.2 | in vivo | 1 138 720 710 970 850 |
| 7431 | VIM | 1899 | NP_003371.2 | in vitro;in vivo | 9565595 |
| 83478 | ARHGAP24 | 9804 | NP_001020787.2 | in vivo | 16862148 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Axon guidance | hsa04360 |
| cAMP signaling pathway | hsa04024 |
| cGMP-PKG signaling pathway | hsa04022 |
| Chemokine signaling pathway | hsa04062 |
| Focal adhesion | hsa04510 |
| Leukocyte transendothelial migration | hsa04670 |
| MicroRNAs in cancer | hsa05206 |
| Oxytocin signaling pathway | hsa04921 |
| Pathogenic Escherichia coli infection | hsa05130 |
| Pathways in cancer | hsa05200 |
| Platelet activation | hsa04611 |
| Proteoglycans in cancer | hsa05205 |
| Regulation of actin cytoskeleton | hsa04810 |
| Salmonella infection | hsa05132 |
| Shigellosis | hsa05131 |
| Sphingolipid signaling pathway | hsa04071 |
| TGF-beta signaling pathway | hsa04350 |
| Vascular smooth muscle contraction | hsa04270 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd05622 | 2-406 | STKc_ROCK1 |
| cl21453 | 2-406 | PKc_like superfamily |
| cd01242 | 1119-1225 | PH_ROCK |
| cl17171 | 1119-1225 | PH-like superfamily |
| cd11639 | 489-554 | HR1_ROCK1 |
| cl00087 | 489-554 | HR1 superfamily |
| cd00029 | 1229-1275 | C1 |
| cl00040 | 1229-1275 | C1 superfamily |
| cd05596 | 49-400 | STKc_ROCK |
| cd05621 | 23-400 | STKc_ROCK2 |
| cd05573 | 74-400 | STKc_ROCK_NDR_like |
| cd05597 | 74-399 | STKc_DMPK_like |
| cd05601 | 74-399 | STKc_CRIK |
| cd05624 | 8-399 | STKc_MRCK_beta |
| cd05599 | 74-399 | STKc_NDR_like |
| cd05623 | 8-402 | STKc_MRCK_alpha |
| cd05598 | 75-405 | STKc_LATS |
| cd05123 | 82-338 | STKc_AGC |
| cd05629 | 74-405 | STKc_NDR_like_fungal |
| cd05579 | 82-343 | STKc_MAST_like |
| cd05580 | 74-370 | STKc_PKA_like |
| cd05600 | 67-399 | STKc_Sid2p_like |
| cd05627 | 74-373 | STKc_NDR2 |
| cd05626 | 79-376 | STKc_LATS2 |
| cd05574 | 75-364 | STKc_phototropin_like |
| cd05570 | 80-400 | STKc_PKC |
| cd05628 | 74-373 | STKc_NDR1 |
| cd05609 | 75-343 | STKc_MAST |
| cd14209 | 74-370 | STKc_PKA |
| cd05625 | 79-375 | STKc_LATS1 |
| cd05612 | 74-373 | STKc_PRKX_like |
| cd05581 | 74-338 | STKc_PDK1 |
| cd05575 | 80-399 | STKc_SGK |
| cd05611 | 79-343 | STKc_Rim15_like |
| cd05589 | 76-402 | STKc_PKN |
| cd05584 | 80-399 | STKc_p70S6K |
| cd05572 | 82-343 | STKc_cGK |
| cd05571 | 80-370 | STKc_PKB |
| cd05592 | 80-399 | STKc_nPKC_theta_like |
| cd05585 | 81-399 | STKc_YPK1_like |
| cd05117 | 75-318 | STKc_CAMK |
| cd05587 | 80-399 | STKc_cPKC |
| cd14007 | 75-339 | STKc_Aurora |
| cd05582 | 80-399 | STKc_RSK_N |
| cd05578 | 76-338 | STKc_Yank1 |
| cd05595 | 80-370 | STKc_PKB_beta |
| cd14003 | 75-335 | STKc_AMPK-like |
| cd05590 | 80-401 | STKc_nPKC_eta |
| cd05591 | 80-399 | STKc_nPKC_epsilon |
| cd05610 | 74-369 | STKc_MASTL |
| cd05586 | 82-369 | STKc_Sck1_like |
| cd05604 | 79-399 | STKc_SGK3 |
| cd05602 | 72-369 | STKc_SGK1 |
| cd05614 | 75-368 | STKc_MSK2_N |
| cd05583 | 81-340 | STKc_MSK_N |
| cd05616 | 75-399 | STKc_cPKC_beta |
| cd14014 | 76-313 | STKc_PknB_like |
| cd05619 | 70-369 | STKc_nPKC_theta |
| cd05588 | 80-369 | STKc_aPKC |
| cd05122 | 75-338 | PKc_STE |
| cd05603 | 80-369 | STKc_SGK2 |
| cd05613 | 75-357 | STKc_MSK1_N |
| cd05620 | 80-369 | STKc_nPKC_delta |
| cd14008 | 82-335 | STKc_LKB1_CaMKK |
| cd05615 | 70-399 | STKc_cPKC_alpha |
| cd05593 | 70-387 | STKc_PKB_gamma |
| cd05594 | 70-370 | STKc_PKB_alpha |
| cd14099 | 74-338 | STKc_PLK |
| cd00180 | 82-271 | PKc |
| cd05577 | 82-358 | STKc_GRK |
| cd05618 | 74-369 | STKc_aPKC_iota |
| cd05617 | 74-369 | STKc_aPKC_zeta |
| cd06606 | 75-313 | STKc_MAPKKK |
| cd08215 | 75-313 | STKc_Nek |
| cd05605 | 80-344 | STKc_GRK4_like |
| cd14663 | 75-335 | STKc_SnRK3 |
| cd14118 | 82-335 | STKc_CAMKK |
| cd14009 | 82-337 | STKc_ATG1_ULK_like |
| cd14081 | 76-338 | STKc_BRSK1_2 |
| cd06623 | 74-313 | PKc_MAPKK_plant_like |
| cd14069 | 74-338 | STKc_Chk1 |
| cd14098 | 75-318 | STKc_Rad53_Cds1 |
| cd05606 | 81-357 | STKc_beta_ARK |
| cd14084 | 67-335 | STKc_Chk2 |
| cd14006 | 82-318 | STKc_MLCK-like |
| cd14162 | 76-338 | STKc_TSSK4-like |
| cd05608 | 80-358 | STKc_GRK1 |
| cd14091 | 75-313 | STKc_RSK_C |
| cd14002 | 74-325 | STKc_STK36 |
| cd14095 | 76-324 | STKc_DCKL |
| cd14078 | 76-294 | STKc_MELK |
| cd08530 | 75-291 | STKc_CNK2-like |
| cd13999 | 82-278 | STKc_MAP3K-like |
| cd14080 | 76-335 | STKc_TSSK-like |
| cd05632 | 80-358 | STKc_GRK5 |
| cd05630 | 80-340 | STKc_GRK6 |
| cd05607 | 80-340 | STKc_GRK7 |
| cd06614 | 76-339 | STKc_PAK |
| cd05631 | 80-358 | STKc_GRK4 |
| cd14083 | 76-314 | STKc_CaMKI |
| cd05633 | 71-376 | STKc_GRK3 |
| cd14223 | 75-376 | STKc_GRK2 |
| cd14116 | 74-317 | STKc_Aurora-A |
| cd14185 | 76-323 | STKc_DCKL3 |
| cd14072 | 76-317 | STKc_MARK |
| cd14093 | 74-338 | STKc_PhKG |
| cd14096 | 74-318 | STKc_RCK1-like |
| cd14073 | 76-278 | STKc_NUAK |
| cd14200 | 76-335 | STKc_CaMKK1 |
| cd08217 | 75-290 | STKc_Nek2 |
| cd06609 | 74-281 | STKc_MST3_like |
| cd08529 | 75-291 | STKc_FA2-like |
| cd14004 | 75-335 | STKc_PASK |
| cd14166 | 74-317 | STKc_CaMKI_gamma |
| cd14086 | 74-356 | STKc_CaMKII |
| cd14103 | 82-317 | STKc_MLCK |
| cd14071 | 76-335 | STKc_SIK |
| cd06612 | 74-279 | STKc_MST1_2 |
| cd13994 | 82-318 | STKc_HAL4_like |
| cd14119 | 82-338 | STKc_LKB1 |
| cd06625 | 80-338 | STKc_MEKK3_like |
| cd14079 | 76-338 | STKc_AMPK_alpha |
| cd14199 | 76-335 | STKc_CaMKK2 |
| cd14074 | 76-335 | STKc_SNRK |
| cd05118 | 76-291 | STKc_CMGC |
| cd14167 | 74-335 | STKc_CaMKI_alpha |
| cd06632 | 80-337 | STKc_MEKK1_plant |
| cd14075 | 76-337 | STKc_NIM1 |
| cd14117 | 70-317 | STKc_Aurora-B_like |
| cd14092 | 80-318 | STKc_MSK_C |
| cd06627 | 76-279 | STKc_Cdc7_like |
| cd06626 | 80-313 | STKc_MEKK4 |
| cd14094 | 74-352 | STKc_CASK |
| cd14662 | 76-335 | STKc_SnRK2 |
| cd14169 | 76-341 | STKc_CaMKI_beta |
| cd14175 | 76-324 | STKc_RSK1_C |
| cd14665 | 76-335 | STKc_SnRK2-3 |
| cd14087 | 76-318 | STKc_PSKH1 |
| cd06610 | 74-338 | STKc_OSR1_SPAK |
| cd08219 | 75-282 | STKc_Nek3 |
| cd14137 | 76-300 | STKc_GSK3 |
| cd06613 | 75-279 | STKc_MAP4K3_like |
| cd07833 | 74-292 | STKc_CDKL |
| cd06605 | 74-339 | PKc_MAPKK |
| cd14181 | 74-338 | STKc_PhKG2 |
| cd14089 | 75-324 | STKc_MAPKAPK |
| cd14178 | 73-324 | STKc_RSK3_C |
| cd14131 | 75-301 | PKc_Mps1 |
| cd14161 | 76-278 | STKc_NUAK2 |
| cd14186 | 74-317 | STKc_PLK4 |
| cd08224 | 75-283 | STKc_Nek6_7 |
| cd14077 | 75-335 | STKc_Kin1_2 |
| cd14188 | 80-338 | STKc_PLK2 |
| cd14176 | 76-317 | STKc_RSK2_C |
| cd06648 | 68-282 | STKc_PAK_II |
| cd13996 | 73-273 | STKc_EIF2AK |
| cd14010 | 82-337 | STKc_ULK4 |
| cd06917 | 76-339 | STKc_NAK1_like |
| cd08225 | 76-283 | STKc_Nek5 |
| cd14182 | 74-339 | STKc_PhKG1 |
| cd14090 | 81-335 | STKc_Mnk |
| cd13978 | 82-278 | STKc_RIP |
| cd06608 | 69-278 | STKc_myosinIII_N_like |
| cd14121 | 82-317 | STKc_ULK3 |
| cd07830 | 76-271 | STKc_MAK_like |
| cd06659 | 68-284 | STKc_PAK6 |
| cd14106 | 73-313 | STKc_DRAK |
| cd14184 | 74-317 | STKc_DCKL2 |
| cd13993 | 76-305 | STKc_Pat1_like |
| cd06630 | 80-293 | STKc_MEKK1 |
| cd08218 | 76-291 | STKc_Nek1 |
| cd06611 | 73-277 | STKc_SLK_like |
| cd06644 | 67-271 | STKc_STK10 |
| cd14050 | 76-270 | PKc_Myt1 |
| cd14171 | 74-335 | STKc_MAPKAPK5 |
| cd14120 | 82-317 | STKc_ULK1_2-like |
| cd14076 | 76-335 | STKc_Kin4 |
| cd14082 | 80-317 | STKc_PKD |
| cd14085 | 76-324 | STKc_CaMKIV |
| cd14165 | 76-338 | STKc_TSSK1_2-like |
| cd07832 | 75-274 | STKc_CCRK |
| cd08220 | 75-317 | STKc_Nek8 |
| cd14177 | 73-350 | STKc_RSK4_C |
| cd06622 | 77-313 | PKc_PBS2_like |
| cd14046 | 75-310 | STKc_EIF2AK4_GCN2_rpt2 |
| cd14187 | 80-313 | STKc_PLK1 |
| cd08228 | 75-283 | STKc_Nek6 |
| cd14168 | 74-353 | STKc_CaMKI_delta |
| cd06629 | 80-337 | STKc_Bck1_like |
| cd05576 | 76-338 | STKc_RPK118_like |
| cd14107 | 76-317 | STKc_obscurin_rpt1 |
| cd14070 | 76-323 | STKc_HUNK |
| cd07829 | 76-292 | STKc_CDK_like |
| cd14191 | 76-324 | STKc_MLCK1 |
| cd14172 | 74-324 | STKc_MAPKAPK3 |
| cd06653 | 74-337 | STKc_MEKK3_like_u1 |
| cd06652 | 75-337 | STKc_MEKK2 |
| cd14005 | 76-338 | STKc_PIM |
| cd14174 | 80-324 | STKc_Mnk1 |
| cd06643 | 74-271 | STKc_SLK |
| cd14183 | 73-317 | STKc_DCKL1 |
| cd14202 | 81-282 | STKc_ULK1 |
| cd08221 | 76-272 | STKc_Nek9 |
| cd14113 | 76-319 | STKc_Trio_C |
| cd06657 | 82-279 | STKc_PAK4 |
| cd07840 | 76-278 | STKc_CDK9_like |
| cd06615 | 74-277 | PKc_MEK |
| cd08528 | 75-294 | STKc_Nek10 |
| cd14180 | 82-331 | STKc_MSK2_C |
| cd13997 | 75-274 | PKc_Wee1_like |
| cd06624 | 81-337 | STKc_ASK |
| cd14179 | 80-318 | STKc_MSK1_C |
| cd08222 | 76-290 | STKc_Nek11 |
| cd14189 | 80-338 | STKc_PLK3 |
| cd07831 | 76-272 | STKc_MOK |
| cd06647 | 76-301 | STKc_PAK_I |
| cd06639 | 56-290 | STKc_myosinIIIB_N |
| cd06620 | 71-339 | PKc_Byr1_like |
| cd06658 | 82-339 | STKc_PAK5 |
| cd07838 | 76-271 | STKc_CDK4_6_like |
| cd14114 | 76-324 | STKc_Twitchin_like |
| cd06651 | 80-337 | STKc_MEKK3 |
| cd14097 | 76-317 | STKc_STK33 |
| cd13987 | 82-277 | STKc_SBK1 |
| cd14192 | 76-317 | STKc_MLCK3 |
| cd06638 | 73-278 | STKc_myosinIIIA_N |
| cd08223 | 75-294 | STKc_Nek4 |
| cd14163 | 76-335 | STKc_TSSK3-like |
| cd11626 | 489-554 | HR1_ROCK |
| cd06628 | 81-313 | STKc_Byr2_like |
| cd06636 | 69-278 | STKc_MAP4K4_6_N |
| cd06621 | 82-318 | PKc_Pek1_like |
| cd08229 | 75-283 | STKc_Nek7 |
| cd14109 | 74-338 | PK_Unc-89_rpt1 |
| cd07846 | 74-291 | STKc_CDKL2_3 |
| cd06642 | 82-278 | STKc_STK25 |
| cd14115 | 82-317 | STKc_Kalirin_C |
| cd06641 | 74-277 | STKc_MST3 |
| cd14111 | 83-294 | STKc_SPEG_rpt2 |
| cd06656 | 74-339 | STKc_PAK3 |
| cd14173 | 80-278 | STKc_Mnk2 |
| cd14201 | 75-282 | STKc_ULK2 |
| cd14052 | 75-270 | PTKc_Wee1_fungi |
| cd07834 | 76-313 | STKc_MAPK |
| cd07841 | 76-317 | STKc_CDK7 |
| cd06655 | 62-278 | STKc_PAK2 |
| cd13990 | 76-313 | STKc_TLK |
| cd06650 | 71-277 | PKc_MEK1 |
| cd14058 | 82-291 | STKc_TAK1 |
| cd06654 | 74-278 | STKc_PAK1 |
| cd14190 | 80-324 | STKc_MLCK2 |
| cd14132 | 74-279 | STKc_CK2_alpha |
| cd06649 | 71-277 | PKc_MEK2 |
| cd07852 | 76-324 | STKc_MAPK15-like |
| cd06645 | 70-279 | STKc_MAP4K3 |
| cd06616 | 73-278 | PKc_MKK4 |
| cd06640 | 82-313 | STKc_MST4 |
| cd06618 | 74-278 | PKc_MKK7 |
| cd14198 | 80-290 | STKc_DRAK2 |
| cd14194 | 74-290 | STKc_DAPK1 |
| cd14196 | 72-335 | STKc_DAPK2 |
| cd14104 | 76-324 | STKc_Titin |
| cd07866 | 72-274 | STKc_BUR1 |
| cd00192 | 80-278 | PTKc |
| cd14108 | 76-323 | STKc_SPEG_rpt1 |
| cd06637 | 69-278 | STKc_TNIK |
| cd06646 | 70-279 | STKc_MAP4K5 |
| cd08216 | 77-278 | PK_STRAD |
| cd14193 | 80-317 | STKc_MLCK4 |
| cd14105 | 72-290 | STKc_DAPK |
| cd14016 | 76-222 | STKc_CK1 |
| cd14170 | 74-380 | STKc_MAPKAPK2 |
| cd14065 | 82-272 | PKc_LIMK_like |
| cd06631 | 81-337 | STKc_YSK4 |
| cd13985 | 76-318 | STKc_GAK_like |
| cd14164 | 76-317 | STKc_TSSK6-like |
| cd06619 | 74-278 | PKc_MKK5 |
| cd11638 | 488-554 | HR1_ROCK2 |
| cd07847 | 74-274 | STKc_CDKL1_4 |
| cd07848 | 76-282 | STKc_CDKL5 |
| cd13989 | 82-278 | STKc_IKK |
| cd07851 | 76-313 | STKc_p38 |
| cd14197 | 80-317 | STKc_DRAK1 |
| cd14048 | 73-272 | STKc_EIF2AK3_PERK |
| cd07855 | 73-272 | STKc_ERK5 |
| cd13986 | 76-318 | STKc_16 |
| cd07860 | 76-282 | STKc_CDK2_3 |
| cd14221 | 82-272 | STKc_LIMK1 |
| cd14019 | 74-284 | STKc_Cdc7 |
| cd14195 | 76-290 | STKc_DAPK3 |
| cd14088 | 76-324 | STKc_CaMK_like |
| cd07835 | 76-282 | STKc_CDK1_CdkB_like |
| cd13991 | 82-292 | STKc_NIK |
| cd06607 | 76-271 | STKc_TAO |
| cd13988 | 82-278 | STKc_TBK1 |
| cd14025 | 82-278 | STKc_RIP4_like |
| cd05041 | 82-278 | PTKc_Fes_like |
| cd13979 | 81-281 | STKc_Mos |
| cd14154 | 82-272 | STKc_LIMK |
| cd14110 | 82-281 | STKc_obscurin_rpt2 |
| cd07843 | 74-292 | STKc_CDC2L1 |
| cd14100 | 136-281 | STKc_PIM1 |
| cd07849 | 73-274 | STKc_ERK1_2_like |
| cd14101 | 76-318 | STKc_PIM2 |
| cd14017 | 76-277 | STKc_TTBK |
| cd14061 | 81-313 | STKc_MLK |
| cd13974 | 159-318 | STKc_SHIK |
| cd14047 | 74-272 | STKc_EIF2AK2_PKR |
| cd07880 | 59-291 | STKc_p38gamma |
| cd07878 | 59-291 | STKc_p38beta |
| cd14102 | 76-281 | STKc_PIM3 |
| pfam08912 | 949-1014 | Rho_Binding |
| cl07487 | 949-1014 | Rho_Binding superfamily |
| cd06617 | 74-278 | PKc_MKK3_6 |
| cd07864 | 76-301 | STKc_CDK12 |
| cd07877 | 59-278 | STKc_p38alpha |
| cd14039 | 82-278 | STKc_IKK_alpha |
| cd14148 | 81-300 | STKc_MLK2 |
| cd06633 | 65-342 | STKc_TAO3 |
| cd07861 | 75-282 | STKc_CDK1_euk |
| cd14145 | 80-300 | STKc_MLK1 |
| cd14064 | 82-278 | PKc_TNNI3K |
| cd13995 | 82-317 | STKc_MAP3K8 |
| cd14147 | 67-300 | STKc_MLK3 |
| cd14027 | 85-278 | STKc_RIP1 |
| cd14066 | 82-279 | STKc_IRAK |
| cd07865 | 76-271 | STKc_CDK9 |
| cd14026 | 79-278 | STKc_RIP2 |
| cd05072 | 74-278 | PTKc_Lyn |
| cd07837 | 74-282 | STKc_CdkB_plant |
| cd14037 | 77-313 | STKc_NAK_like |
| cd07845 | 75-282 | STKc_CDK10 |
| cd14012 | 140-285 | PK_eIF2AK_GCN2_rpt1 |
| cd14038 | 82-278 | STKc_IKK_beta |
| cd05032 | 74-278 | PTKc_InsR_like |
| cd07850 | 76-307 | STKc_JNK |
| cd07871 | 72-284 | STKc_PCTAIRE3 |
| cd14060 | 83-278 | STKc_MLTK |
| cd05082 | 71-278 | PTKc_Csk |
| cd13982 | 80-338 | STKc_IRE1 |
| cd14146 | 81-300 | STKc_MLK4 |
| cd14222 | 82-281 | STKc_LIMK2 |
| cd14059 | 151-278 | STKc_MAP3K12_13 |
| cd07879 | 59-291 | STKc_p38delta |
| cd05081 | 79-272 | PTKc_Jak3_rpt2 |
| cd14136 | 76-293 | STKc_SRPK |
| cd14229 | 76-310 | STKc_HIPK3 |
| cd05067 | 74-278 | PTKc_Lck_Blk |
| cd05039 | 70-271 | PTKc_Csk_like |
| cd14133 | 76-291 | PKc_DYRK_like |
| cd05059 | 79-278 | PTKc_Tec_like |
| cd14112 | 136-278 | STKc_Unc-89_rpt2 |
| cd06635 | 79-342 | STKc_TAO1 |
| cd07857 | 76-327 | STKc_MPK1 |
| cd01243 | 1121-1198 | PH_MRCK |
| cd14134 | 76-278 | PKc_CLK |
| cd05038 | 79-272 | PTKc_Jak_rpt2 |
| cd05047 | 81-290 | PTKc_Tie |
| cd07839 | 76-279 | STKc_CDK5 |
| cd14203 | 80-278 | PTKc_Src_Fyn_like |
| cd07854 | 147-278 | STKc_MAPK4_6 |
| cd07856 | 74-290 | STKc_Sty1_Hog1 |
| cd05084 | 82-278 | PTKc_Fes |
| cd07862 | 74-292 | STKc_CDK6 |
| cd05085 | 80-278 | PTKc_Fer |
| cd14155 | 82-272 | PKc_TESK |
| cd05114 | 79-278 | PTKc_Tec_Rlk |
| cd05044 | 80-282 | PTKc_c-ros |
| cd07836 | 136-300 | STKc_Pho85 |
| cd06634 | 79-279 | STKc_TAO2 |
| cd07853 | 75-284 | STKc_NLK |
| cd14227 | 76-279 | STKc_HIPK2 |
| cd14664 | 82-278 | STK_BAK1_like |
| smart00109 | 1229-1275 | C1 |
| cd05113 | 71-278 | PTKc_Btk_Bmx |
| cd14000 | 81-278 | STKc_LRRK |
| cd14228 | 76-279 | STKc_HIPK1 |
| cd07859 | 76-284 | STKc_TDY_MAPK |
| cd07872 | 72-284 | STKc_PCTAIRE2 |
| cd14041 | 76-313 | STKc_TLK2 |
| cd14063 | 75-313 | PK_KSR |
| cd05051 | 74-219 | PTKc_DDR |
| cd05089 | 74-290 | PTKc_Tie1 |
| cd13981 | 76-218 | STKc_Bub1_BubR1 |
| cd14024 | 144-317 | PK_TRB3 |
| cd05070 | 74-278 | PTKc_Fyn |
| cd05060 | 82-278 | PTKc_Syk_like |
| cd05112 | 79-278 | PTKc_Itk |
| cd05058 | 80-281 | PTKc_Met_Ron |
| cd08227 | 77-278 | PK_STRAD_alpha |
| cd14040 | 74-313 | STKc_TLK1 |
| cd14159 | 82-287 | STKc_IRAK1 |
| cd13968 | 82-218 | PKc_like |
| cd13975 | 181-274 | PKc_Dusty |
| cd07844 | 76-274 | STKc_PCTAIRE_like |
| cd07870 | 136-278 | STKc_PFTAIRE2 |
| cd07869 | 72-278 | STKc_PFTAIRE1 |
| cd14211 | 76-279 | STKc_HIPK |
| cd07873 | 74-284 | STKc_PCTAIRE1 |
| cd05095 | 82-272 | PTKc_DDR2 |
| cd05097 | 82-273 | PTKc_DDR_like |
| cd07842 | 76-304 | STKc_CDK8_like |
| cd14023 | 172-338 | PK_TRB1 |
| cd14224 | 76-274 | PKc_DYRK2_3 |
| cd14158 | 82-278 | STKc_IRAK4 |
| cd14156 | 82-272 | PKc_LIMK_like_unk |
| cd07875 | 76-293 | STKc_JNK1 |
| cd14068 | 81-274 | STKc_LRRK2 |
| cd07858 | 76-313 | STKc_TEY_MAPK |
| cd05066 | 71-279 | PTKc_EphR_A |
| cd13976 | 236-338 | PK_TRB |
| cd14022 | 236-338 | PK_TRB2 |
| cd05036 | 79-278 | PTKc_ALK_LTK |
| smart00133 | 345-399 | S_TK_X |
| cl11395 | 345-399 | Pkinase_C superfamily |
| cd07874 | 76-293 | STKc_JNK3 |
| cd07863 | 76-292 | STKc_CDK4 |
| cd05073 | 74-278 | PTKc_Hck |
| cd14210 | 76-274 | PKc_DYRK |
| cd05074 | 66-278 | PTKc_Tyro3 |
| cd07876 | 76-291 | STKc_JNK2 |
| cd13983 | 121-278 | STKc_WNK |
| cd05069 | 82-278 | PTKc_Yes |
| cd14062 | 181-292 | STKc_Raf |
| cd05088 | 75-290 | PTKc_Tie2 |
| cd14031 | 82-341 | STKc_WNK3 |
| cd14011 | 123-340 | PK_SCY1_like |
| cd14150 | 77-278 | STKc_A-Raf |
| cd14049 | 75-272 | STKc_EIF2AK1_HRI |
| cd05148 | 74-278 | PTKc_Srm_Brk |
| cd05083 | 80-278 | PTKc_Chk |
| cd05092 | 65-279 | PTKc_TrkA |
| cd05033 | 78-279 | PTKc_EphR |
| cd05075 | 80-278 | PTKc_Axl |
| cd05096 | 82-272 | PTKc_DDR1 |
| cd05068 | 77-278 | PTKc_Frk_like |
| cd14129 | 76-278 | STKc_TTBK2 |
| cd05055 | 80-292 | PTKc_PDGFR |
| cd13977 | 148-289 | STKc_PDIK1L |
| cd05079 | 60-282 | PTKc_Jak1_rpt2 |
| cd14215 | 74-278 | PKc_CLK2 |
| cd05034 | 80-271 | PTKc_Src_like |
| cd05071 | 82-278 | PTKc_Src |
| cd14149 | 185-278 | STKc_C-Raf |
| cd00089 | 489-554 | HR1 |
| cd14135 | 76-274 | STKc_PRP4 |
| cd05101 | 80-278 | PTKc_FGFR2 |
| cd05080 | 79-272 | PTKc_Tyk2_rpt2 |
| cd05049 | 71-282 | PTKc_Trk |
| cd14130 | 76-278 | STKc_TTBK1 |
| cd14013 | 181-244 | STKc_SNT7_plant |
| cd08226 | 77-278 | PK_STRAD_beta |
| cd05090 | 121-282 | PTKc_Ror1 |
| cd05052 | 82-290 | PTKc_Abl |
| cd14151 | 185-278 | STKc_B-Raf |
| cd14205 | 79-272 | PTKc_Jak2_rpt2 |
| cd14128 | 76-222 | STKc_CK1_alpha |
| cd14033 | 82-278 | STKc_WNK4 |
| cd05050 | 75-279 | PTKc_Musk |
| cd14144 | 149-271 | STKc_BMPR1 |
| cd14226 | 73-290 | PKc_DYRK1 |
| cd14212 | 76-274 | PKc_YAK1 |
| cd14018 | 164-279 | STKc_PINK1 |
| cd05098 | 80-278 | PTKc_FGFR1 |
| cd00821 | 1121-1203 | PH |
| smart00220 | 76-338 | S_TKc |
| pfam00069 | 76-338 | Pkinase |
| PTZ00263 | 72-397 | PTZ00263 |
| PTZ00426 | 67-374 | PTZ00426 |
| COG0515 | 75-427 | SPS1 |
| PHA03390 | 74-340 | pk1 |
| PLN00034 | 74-278 | PLN00034 |
| pfam07714 | 80-279 | Pkinase_Tyr |
| smart00221 | 80-302 | STYKc |
| COG0419 | 422-1027 | SbcC |
| smart00219 | 80-302 | TyrKc |
| COG1196 | 447-1097 | Smc |
| TIGR02168 | 450-1097 | SMC_prok_B |
| PTZ00267 | 103-282 | PTZ00267 |
| COG1196 | 422-1092 | Smc |
| TIGR02168 | 412-1097 | SMC_prok_B |
| PTZ00266 | 64-279 | PTZ00266 |
| COG1196 | 458-833 | Smc |
| TIGR02169 | 405-1090 | SMC_prok_A |
| TIGR02168 | 494-1099 | SMC_prok_B |
| pfam01576 | 448-850 | Myosin_tail_1 |
| PRK13184 | 76-278 | pknD |
| PTZ00283 | 70-317 | PTZ00283 |
| PRK03918 | 419-965 | PRK03918 |
| COG1196 | 508-848 | Smc |
| COG0419 | 460-1090 | SbcC |
| PTZ00036 | 70-317 | PTZ00036 |
| TIGR02168 | 426-1066 | SMC_prok_B |
| PLN00009 | 74-290 | PLN00009 |
| TIGR04523 | 412-1058 | Mplasa_alph_rch |
| pfam01576 | 422-964 | Myosin_tail_1 |
| pfam05483 | 418-1091 | SCP-1 |
| pfam01576 | 417-1066 | Myosin_tail_1 |
| PHA03210 | 147-275 | PHA03210 |
| pfam02463 | 399-1099 | SMC_N |
| TIGR02169 | 471-931 | SMC_prok_A |
| pfam05483 | 501-1061 | SCP-1 |
| TIGR00618 | 497-1100 | sbcc |
| PHA03207 | 39-303 | PHA03207 |
| PTZ00024 | 80-292 | PTZ00024 |
| COG0419 | 415-805 | SbcC |
| COG1196 | 423-966 | Smc |
| TIGR02169 | 434-1100 | SMC_prok_A |
| pfam12128 | 465-1101 | DUF3584 |
| TIGR02169 | 459-1126 | SMC_prok_A |
| COG0419 | 420-847 | SbcC |
| pfam10174 | 434-1094 | Cast |
| pfam07888 | 489-829 | CALCOCO1 |
| pfam12128 | 422-1090 | DUF3584 |
| TIGR02169 | 420-670 | SMC_prok_A |
| TIGR00606 | 422-1088 | rad50 |
| TIGR02168 | 749-1094 | SMC_prok_B |
| COG4942 | 475-719 | EnvC |
| TIGR00606 | 415-1094 | rad50 |
| COG1196 | 624-962 | Smc |
| pfam02463 | 412-1050 | SMC_N |
| pfam05557 | 414-960 | MAD |
| COG1196 | 633-1010 | Smc |
| pfam12128 | 344-965 | DUF3584 |
| PRK02224 | 447-964 | PRK02224 |
| TIGR00618 | 448-966 | sbcc |
| pfam05622 | 419-720 | HOOK |
| TIGR04523 | 406-771 | Mplasa_alph_rch |
| TIGR02169 | 523-844 | SMC_prok_A |
| TIGR03903 | 103-249 | TOMM_kin_cyc |
| pfam05557 | 401-1091 | MAD |
| pfam07888 | 427-718 | CALCOCO1 |
| TIGR02168 | 415-698 | SMC_prok_B |
| COG4942 | 529-783 | EnvC |
| pfam09789 | 450-712 | DUF2353 |
| TIGR00618 | 413-769 | sbcc |
| pfam05622 | 421-685 | HOOK |
| TIGR00606 | 503-1094 | rad50 |
| PHA03212 | 182-285 | PHA03212 |
| PRK11637 | 520-707 | PRK11637 |
| COG4372 | 736-962 | COG4372 |
| PHA03209 | 160-272 | PHA03209 |
| pfam10174 | 445-830 | Cast |
| TIGR02169 | 413-965 | SMC_prok_A |
| TIGR02168 | 872-1097 | SMC_prok_B |
| TIGR02168 | 412-707 | SMC_prok_B |
| pfam05557 | 745-1110 | MAD |
| TIGR02168 | 644-966 | SMC_prok_B |
| COG0497 | 472-699 | RecN |
| COG4372 | 539-847 | COG4372 |
| TIGR04523 | 732-1090 | Mplasa_alph_rch |
| pfam05622 | 425-933 | HOOK |
| pfam05483 | 576-1100 | SCP-1 |
| TIGR01843 | 761-958 | type_I_hlyD |
| pfam02463 | 576-1098 | SMC_N |
| pfam05483 | 419-709 | SCP-1 |
| TIGR03319 | 642-810 | RNase_Y |
| COG3883 | 490-710 | CwlO1 |
| COG4372 | 424-658 | COG4372 |
| pfam05483 | 428-818 | SCP-1 |
| TIGR02169 | 745-1066 | SMC_prok_A |
| PRK03918 | 644-1118 | PRK03918 |
| PRK02224 | 589-1099 | PRK02224 |
| pfam07888 | 748-1121 | CALCOCO1 |
| TIGR00606 | 413-851 | rad50 |
| COG4942 | 736-930 | EnvC |
| TIGR04523 | 633-1098 | Mplasa_alph_rch |
| pfam10174 | 428-810 | Cast |
| COG5185 | 400-814 | HEC1 |
| TIGR02169 | 426-655 | SMC_prok_A |
| COG4477 | 423-701 | EzrA |
| TIGR04211 | 510-598 | SH3_and_anchor |
| COG2433 | 422-588 | COG2433 |
| TIGR00606 | 678-1097 | rad50 |
| TIGR01612 | 447-1171 | 235kDa-fam |
| TIGR04211 | 465-560 | SH3_and_anchor |
| TIGR03007 | 494-694 | pepcterm_ChnLen |
| TIGR02169 | 613-969 | SMC_prok_A |
| COG4372 | 434-618 | COG4372 |
| COG4717 | 435-1092 | YhaN |
| COG1511 | 476-712 | YhgE |
| COG3096 | 476-690 | MukB |
| TIGR01612 | 503-707 | 235kDa-fam |
| COG5281 | 875-1100 | COG5281 |
| TIGR03319 | 483-665 | RNase_Y |
| pfam01576 | 803-1102 | Myosin_tail_1 |
| COG4942 | 595-854 | EnvC |
| COG4372 | 784-1074 | COG4372 |
| TIGR01843 | 502-688 | type_I_hlyD |
| COG4477 | 459-822 | EzrA |
| TIGR03346 | 443-563 | chaperone_ClpB |
| TIGR03319 | 394-571 | RNase_Y |
| COG1322 | 490-642 | RmuC |
| TIGR01843 | 416-589 | type_I_hlyD |
| COG3206 | 576-860 | GumC |
| TIGR04211 | 1016-1106 | SH3_and_anchor |
| COG5022 | 495-818 | COG5022 |
| TIGR01069 | 568-676 | mutS2 |
| COG1579 | 481-647 | COG1579 |
| TIGR00634 | 496-801 | recN |
| COG4942 | 876-1151 | EnvC |
| TIGR04211 | 748-853 | SH3_and_anchor |
| TIGR04211 | 518-625 | SH3_and_anchor |
Ontology Information
| HPRD ID | 16020 |
|---|---|
| Molecular Class | Serine/threonine kinase |
| Molecular Function | Molecular function unknown (GO:0005554) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.