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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
RORA 6095 RAR-related orphan receptor A  15RZRA, ROR1, ROR2, ROR3, NR1F1 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
22104449   2012Cell line : -

Source : -

Sample Type : -

No. of Sample : -

Stage : -

-Down-regulation-RORA expression was downregulated in CRC adenocarcinomas compared to normal controls and correlated with time to disease progression.


Gene Details



NC_000015.9 (60780483..61521502, complement)

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Gene Type protein coding
Gene Family Nuclear hormone receptors
Description The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The encoded protein has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, as well as with NM23-1, the product of a tumor metastasis suppressor candidate gene. Also, it has been shown to aid in the transcriptional regulation of some genes involved in circadian rhythm. Four transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2014]  
Chromosome 15
Location 15q21-q22
Start 60780483  
End 61521502  
Strand -  
Gene Sequence

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Length 741020  
OMIM ID 600825   
HGNC ID HGNC:10258   
Unigene ID Hs.560343   
Ensembl ID ENSG00000069667   
PharmGKB ID PA34630   

mRNA Information


mRNA ID ?NM_002943.3
Exon join(1..251,550618..550647,697453..697538,714547..714688, 717683..718078,723675..723796,725637..725769, 726437..726544,728235..728345,729300..729412, 731685..741020)  
mRNA Sequence

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Length 10828  



CDS Information


   
Location86..1657
CDS Sequence

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CCDS ID CCDS10177.1



Protein Information


      
Protein IDNP_002934.1
Protein NameRAR-related orphan receptor A
Molecular Wt. (Da)68007
Protein Sequence

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Length 523  
Uniprot IDO95389
Ensembl Protein ID ENSP00000230529  



Post-translational Modification Information (Source : HPRD)


No matching records could be found.

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                       
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
4654MYOD11166NP_002469.2in vitro9862959   
4830NME11131NP_937818.1in vitro;yeast 2-hybrid8858107   
4831NME21132NP_001018146.1in vitro;yeast 2-hybrid8858107   
5629PROX13330NP_002754.2yeast 2-hybrid15604093   
5705PSMC53400NP_002796.4yeast 2-hybrid1   618   951   416   713   560   
10957PNRC18412NP_006804.1yeast 2-hybrid15604093   
10987COPS56888NP_006828.2yeast 2-hybrid15604093   
55629PNRC217871NP_060231.1yeast 2-hybrid15604093   
55885LMO311832NP_061110.2yeast 2-hybrid16713569   


Pathway Information


            
Pathway Name Pathway ID
Circadian rhythm hsa04710
Inflammatory bowel disease (IBD) hsa05321


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd06939272-511  NR_LBD_ROR_like
cl11397272-511  NR_LBD superfamily
cd0696866-160  NR_DBD_ROR
cl0259666-160  NR_DBD_like superfamily
cd06929317-488  NR_LBD_F1
cd0691673-144  NR_DBD_like
cd06940319-492  NR_LBD_REV_ERB
pfam0010571-140  zf-C4
cd0716671-153  NR_DBD_REV_ERB
cd06157321-480  NR_LBD
pfam00104302-492  Hormone_recep
cd0716573-153  NR_DBD_DmE78_like
cd0696472-151  NR_DBD_RAR
cd06941319-511  NR_LBD_DmE78_like
smart0039972-141  ZnF_C4
cd0696073-147  NR_DBD_HNF4A
cd0696572-156  NR_DBD_Ppar
cd0696172-143  NR_DBD_TR
cd06935327-510  NR_LBD_TR
cd0716773-148  NR_DBD_Lrh-1_like
cd0717973-146  2DBD_NR_DBD2
cd0716973-148  NR_DBD_GCNF_like
cd0715873-144  NR_DBD_Ppar_like
cd0696972-144  NR_DBD_NGFI-B
cd0696773-147  NR_DBD_TR2_like
cd0716473-147  NR_DBD_PNR_like_1
cd06937318-510  NR_LBD_RAR
cd0716365-147  NR_DBD_TLX
cd0716873-148  NR_DBD_DHR4_like
cd0695673-144  NR_DBD_RXR
cd0695873-144  NR_DBD_COUP_TF
cd06954331-511  NR_LBD_LXR
smart00430331-480  HOLI
cd06932312-511  NR_LBD_PPAR
cd0715473-144  NR_DBD_PNR_like
cd0715673-143  NR_DBD_VDR_like
cd0717173-147  NR_DBD_ER
cd0716273-153  NR_DBD_PXR
cd0695773-153  NR_DBD_PNR_like_2
cd0695973-143  NR_DBD_EcR_like
cd0716173-153  NR_DBD_EcR
cd0715573-147  NR_DBD_ER_like
cd0696273-153  NR_DBD_FXR
cd0697073-147  NR_DBD_PNR
cd0696673-164  NR_DBD_CAR
cd06938327-492  NR_LBD_EcR
cd0716073-153  NR_DBD_LXR
cd0717073-148  NR_DBD_ERR
cd0695573-143  NR_DBD_VDR
cd06936328-493  NR_LBD_Fxr
cd0715772-139  2DBD_NR_DBD1
cd06933327-514  NR_LBD_VDR
cd0717372-145  NR_DBD_AR
cd0717272-145  NR_DBD_GR_PR
cd0696373-145  NR_DBD_GR_like
cd06942320-508  NR_LBD_Sex_1_like
cd06934328-510  NR_LBD_PXR_like
cd06945328-481  NR_LBD_Nurr1_like
cd07072327-513  NR_LBD_DHR38_like
cd06930334-480  NR_LBD_F2
cd07348327-511  NR_LBD_NGFI-B
cd06943306-492  NR_LBD_RXR_like
cd07071327-492  NR_LBD_Nurr1
cd06952387-501  NR_LBD_TR2_like
cd07068317-461  NR_LBD_ER_like
cd06948335-488  NR_LBD_COUP-TF
cd06949331-492  NR_LBD_ER
cd06946334-461  NR_LBD_ERR


Ontology Information


   
HPRD ID16019
Molecular ClassNuclear receptor
Molecular FunctionGrowth factor activity (GO:0008083); Signal transducer activity (GO:0004871)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165); Anti-apoptosis (GO:0006916)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO