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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
RPA1 6117 replication protein A1, 70kDa  17REPA1, RPA70, HSSB, RF-A, RP-A 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
17361204   2007Cell line : -

Source : -

Sample Type : CRC Tumor

No. of Sample : 130 colon cancer resection specimens were studied.

Stage : TNM Stage I-IV.

 immunohistochemistryUp-regulation- RPA1 and RPA2 proteins appear to be useful prognostic indicators in colon cancer patients and attractive therapeutic targets for regulation by tumor suppressors or other proteins involved in the control of cell proliferation.


Gene Details



NC_000017.10 (1733273..1802848)

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Gene Type protein coding
Gene Family -
Description -  
Chromosome 17
Location 17p13.3
Start 1733273  
End 1802848  
Strand +  
Gene Sequence

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Length 69576  
OMIM ID 179835   
HGNC ID HGNC:10289   
Unigene ID Hs.461925   
Ensembl ID ENSG00000132383   
PharmGKB ID PA34651   

mRNA Information


mRNA ID ?NM_002945.3
Exon join(1..148,12825..12875,13942..14020,14600..14708, 23123..23211,42456..42548,45683..45815,47234..47336, 49015..49083,49237..49429,49582..49721,50565..50713, 53834..53966,58697..58873,61855..61962,65031..65117, 67093..69576)  
mRNA Sequence

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Length 4345  



CDS Information


   
Location 116..1966
CDS Sequence

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CCDS ID CCDS11014.1



Protein Information


      
Protein IDNP_002936.1
Protein Namereplication protein A1, 70kDa
Molecular Wt. (Da)23335
Protein Sequence

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Length 616  
Uniprot IDO76076
Ensembl Protein ID ENSP00000190983  



Post-translational Modification Information (Source : HPRD)


Residue Type site
TPhosphorylation180;-
SPhosphorylation384
TPhosphorylation191
KAcetylation167
KAcetylation163
KAcetylation259
TPhosphorylation164
SPhosphorylation6
SPhosphorylation135
TPhosphorylation590
YPhosphorylation599
TPhosphorylation35
SPhosphorylation463
SPhosphorylation464
TPhosphorylation467
YPhosphorylation470

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                                      
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
4171MCM2303NP_004517.2yeast 2-hybrid12614612   
5111PCNA1456NP_002583.1in vitro12171929   
5888RAD511557NP_597994.3in vitro;in vivo120   771   339   826   763   
6919TCEA216069NP_003186.1yeast 2-hybrid16169070   
8991SELENBP15007NP_003935.2yeast 2-hybrid16169070   
51236C8orf30A17423NP_057542.2yeast 2-hybrid16169070   
55147RBM2315227NP_001070819.1yeast 2-hybrid16169070   
64400AKTIP7467NP_071921.1yeast 2-hybrid16169070   
84164ASCC216515NP_115580.2yeast 2-hybrid16169070   
92797HELB9979NP_387467.2in vitro12181327   


Pathway Information


                              
Pathway Name Pathway ID
DNA replication hsa03030
Fanconi anemia pathway hsa03460
Homologous recombination hsa03440
Mismatch repair hsa03430
Nucleotide excision repair hsa03420


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd04476447-611  RPA1_DBD_C
cl09930447-611  RPA_2b-aaRSs_OBF_like superfamily
cd04474186-288  RPA1_DBD_A
cl09930186-288  RPA_2b-aaRSs_OBF_like superfamily
cd04475316-416  RPA1_DBD_B
cl09930316-416  RPA_2b-aaRSs_OBF_like superfamily
cd044778-103  RPA1N
cl099308-103  RPA_2b-aaRSs_OBF_like superfamily
pfam08646461-606  Rep_fac-A_C
pfam040575-104  Rep-A_N
cd04481333-407  RPA1_DBD_B_like
cd04480198-286  RPA1_DBD_A_like
pfam01336197-263  tRNA_anti-codon
cd03524198-278  RPA2_OBF_family
cd04491198-270  SoSSB_OBF
cd04491318-400  SoSSB_OBF
pfam01485481-507  IBR
cl19760481-507  IBR superfamily
TIGR006172-612  rpa1
COG1599182-475  RFA1
PRK12366180-575  PRK12366
PRK07211187-367  PRK07211
PRK12366186-366  PRK12366
PRK14699181-365  PRK14699
PRK14699201-369  PRK14699
PRK15491199-369  PRK15491
COG0587184-256  DnaE


Ontology Information


   
HPRD ID8950
Molecular ClassDNA binding protein
Molecular FunctionTranscription regulator activity (GO:0030528)
Biological ProcessRegulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO