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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
BCR 613 breakpoint cluster region  22D22S662, CML, PHL, ALL 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
17196995   2007Cell line : -

Source : Roswell Park Cancer Institute

Sample Type : CRC Tumor and adjecent normal tissue

No. of Sample : 32

Stage : TNM stages I-IV

BAC-array comparative genomic hybridization.Amplification/Mutation- BCR-ABL translocation of CML may be involved in genomic instability in about one-third of human colorectal carcinomas.


Gene Details



NC_000022.10 (23522402..23660224)

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Gene Type protein coding
Gene Family Rho guanine nucleotide exchange factors, "Pleckstrin homology (PH) domain containing"
Description A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]  
Chromosome 22
Location 22q11
Start 23522402  
End 23660224  
Strand +  
Gene Sequence

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Length 137823  
OMIM ID 151410   
HGNC ID HGNC:1014   
Unigene ID Hs.517461   
Ensembl ID ENSG00000186716   
PharmGKB ID PA25321   

mRNA Information


mRNA ID NM_004327.3
Exon join(1..1875,73435..73616,80586..80690,80991..81176, 88044..88151,91168..91228,92717..92769,93270..93410, 103613..103734,104669..104837,106795..106914, 107733..107808,109153..109257,109975..110049, 112177..112274,114660..114791,129060..129119, 129960..130069,131333..131472,132523..132657, 133604..133709,134188..134350,135069..137673)  
mRNA Sequence

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Length 6927  



CDS Information


   
Location 597..4412
CDS Sequence

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CCDS ID CCDS13806.1



Protein Information


      
Protein IDNP_004318.3
Protein Namebreakpoint cluster region
Molecular Wt. (Da)142689
Protein Sequence

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Length 1271  
Uniprot IDP14780
Ensembl Protein ID ENSP00000361405  



Post-translational Modification Information (Source : HPRD)


Residue Type site
YPhosphorylation283
TPhosphorylation310
SPhosphorylation354
SPhosphorylation459
SPhosphorylation463
YPhosphorylation591
YPhosphorylation644
YPhosphorylation283
TPhosphorylation310
SPhosphorylation354
SPhosphorylation459
SPhosphorylation463
YPhosphorylation591
YPhosphorylation644
YPhosphorylation177
YPhosphorylation177
YPhosphorylation328
YPhosphorylation360
YPhosphorylation328
YPhosphorylation360
YDephosphorylation177
YDephosphorylation177
YPhosphorylation177
YPhosphorylation246
YPhosphorylation276
YPhosphorylation279
YPhosphorylation246
YPhosphorylation276
YPhosphorylation279
SPhosphorylation467;-
SPhosphorylation467;-
SPhosphorylation356
SPhosphorylation356
SPhosphorylation122
SPhosphorylation122
YPhosphorylation436
YPhosphorylation436
YPhosphorylation598
YPhosphorylation598
SPhosphorylation1264
SPhosphorylation1220
SPhosphorylation315
SPhosphorylation317
SPhosphorylation315
SPhosphorylation317

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                                                                                                                                
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
2071ERCC3593NP_000113.1in vitro;in vivo9874796   
2810SFN3185NP_006133.1in vitro16045749   
2885GRB2150NP_002077.1in vitro;in vivo81   122   929   178   913   
3717JAK2993NP_004963.1in vitro;in vivo1   237   080   312   023   980   
4301MLLT41164NP_001035090.1in vitro;yeast 2-hybrid12808105   
5335PLCG11398NP_002651.2in vitro1383690   
5921RASA1745NP_002881.1in vitro1383690   
6714SRC1819NP_005408.1in vitro1383690   
7157TP531859NP_000537.3yeast 2-hybrid16169070   
7529YWHAB3184NP_003395.1in vitro16045749   
7531YWHAE5457NP_006752.1in vivo16045749   
7532YWHAG5639NP_036611.2in vitro16045749   
7533YWHAH215NP_003396.1in vitro16045749   
9094UNC1194927NP_005139.1yeast 2-hybrid16169070   
10971YWHAQ886NP_006817.1in vitro16045749   
84966IGSF2111309NP_116269.2yeast 2-hybrid16169070   


Pathway Information


            
Pathway Name Pathway ID
Chronic myeloid leukemia hsa05220
Pathways in cancer hsa05200


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd043871052-1252  RhoGAP_Bcr
cl025701052-1252  RhoGAP superfamily
cd13367684-877  PH_BCR_vertebrate
cl17171684-877  PH-like superfamily
cd08686913-1033  C2_ABR
cl14603913-1033  C2 superfamily
cd00160499-689  RhoGEF
cl02571499-689  RhoGEF superfamily
cd13366684-867  PH_ABR
cd01228707-867  PH_BCR-related
smart003241067-1230  RhoGAP
pfam006201068-1219  RhoGAP
cd001591068-1221  RhoGAP
cd044031052-1224  RhoGAP_ARHGAP27_15_12_9
cd043981052-1212  RhoGAP_fRGD1
cd043721052-1216  RhoGAP_chimaerin
pfam00621502-690  RhoGEF
cd043951051-1216  RhoGAP_ARHGAP21
pfam09036Feb-72  Bcr-Abl_Oligo
cl07596Feb-72  Bcr-Abl_Oligo superfamily
smart00325502-690  RhoGEF
cd043791052-1252  RhoGAP_SYD1
cd043781052-1224  RhoGAP_GMIP_PARG1
cd043821067-1246  RhoGAP_MgcRacGAP
cd043861051-1219  RhoGAP_nadrin
cd043841051-1219  RhoGAP_CdGAP
cd043771052-1213  RhoGAP_myosin_IX
cd13368707-868  PH_BCR_arthropod
cd043741070-1216  RhoGAP_Graf
cd043811052-1211  RhoGap_RalBP1
cd044091052-1219  RhoGAP_PARG1
cd043731052-1214  RhoGAP_p190
cd043851064-1219  RhoGAP_ARAP
cd044081052-1214  RhoGAP_GMIP
cd043911051-1231  RhoGAP_ARHGAP18
cd044001051-1216  RhoGAP_fBEM3
cd043901050-1214  RhoGAP_ARHGAP22_24_25
cd044041052-1225  RhoGAP-p50rhoGAP
cd044071052-1213  RhoGAP_myosin_IXB
cd043831067-1213  RhoGAP_srGAP
cd043761066-1219  RhoGAP_ARHGAP6
cd043931051-1209  RhoGAP_FAM13A1a
cd044061052-1213  RhoGAP_myosin_IXA
cd043751051-1227  RhoGAP_DLC1
cd043891052-1213  RhoGAP_KIAA1688
cd043941087-1224  RhoGAP-ARHGAP11A
cd043921087-1224  RhoGAP_ARHGAP19
cd043971052-1219  RhoGAP_fLRG1
cd044021067-1215  RhoGAP_ARHGAP20
cd043961066-1212  RhoGAP_fSAC7_BAG7
cd043881068-1239  RhoGAP_p85
cd043801014-1218  RhoGAP_OCRL1
smart00239912-1016  C2
cd00030913-1007  C2
pfam00168913-1000  C2
cd043991052-1214  RhoGAP_fRGD2
cd13242705-748  PH_puratrophin-1
cd04044911-1044  C2A_Tricalbin-like
cd04043917-1012  C2_Munc13_fungal
cd08678925-1006  C2_C21orf25-like
cd08391923-979  C2A_C2C_Synaptotagmin_like
cd13243709-778  PH_PLEKHG1_G2_G3
PRK1437696-168  PRK14376
cl0050696-168  Haemolytic superfamily
cd04041911-1016  C2A_fungal
cd01221701-742  PH_ephexin
PHA0330780-387  PHA03307
PRK0700380-156  PRK07003
PHA0337879-175  PHA03378
PRK0776472-148  PRK07764
PRK0776479-153  PRK07764
PRK0776475-148  PRK07764
PHA0337878-152  PHA03378
PRK0776478-163  PRK07764
pfam04733540-684  Coatomer_E
PRK1232378-175  PRK12323
PRK0776478-175  PRK07764
PHA0337878-149  PHA03378
PRK1232378-153  PRK12323
PHA0324779-153  PHA03247
PRK0776480-153  PRK07764
PRK1232379-148  PRK12323
PRK0700379-175  PRK07003
PRK1227080-152  kgd
PRK0776469-148  PRK07764
PRK1237264-131  PRK12372
PRK1232380-153  PRK12323
PHA0324778-171  PHA03247
PRK1495178-163  PRK14951
PRK0776479-153  PRK07764
PHA0330778-173  PHA03307
PHA0316982-146  PHA03169
PRK0776480-153  PRK07764
PRK0599678-153  motB
PRK0776480-151  PRK07764
PRK1227065-153  kgd
PRK1237365-175  PRK12373
PHA0330764-172  PHA03307
PHA0324777-156  PHA03247
PRK0776474-175  PRK07764
PRK0776475-153  PRK07764
PHA0324781-175  PHA03247
COG5038911-1021  COG5038
PRK0776473-153  PRK07764
PRK0700378-153  PRK07003
PHA0330776-156  PHA03307
PRK0129772-144  PRK01297
PRK1237280-150  PRK12372


Ontology Information


   
HPRD ID1704
Molecular ClassSerine/threonine kinase
Molecular FunctionMetallopeptidase activity (GO:0008237)
Biological ProcessProtein metabolism (GO:0019538)  



SNP Information


View SNP Geneview Report   

Drug Information


Uniprot ID DrugBank ID Name Type
P11274DB06616BosutinibSmallMoleculeDrug
P11274DB08901PonatinibSmallMoleculeDrug

External Links


                                 
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Cancer3DGO
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NCGGO
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Tumor Gene Family of DatabasesGO
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Osteosarcoma DatabaseGO
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