Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| BCR | 613 | breakpoint cluster region  | 22 | D22S662, CML, PHL, ALL  |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 17196995    | 2007 | Cell line : - Source : Roswell Park Cancer Institute Sample Type : CRC Tumor and adjecent normal tissue No. of Sample : 32 Stage : TNM stages I-IV | BAC-array comparative genomic hybridization. | Amplification/Mutation | - | BCR-ABL translocation of CML may be involved in genomic instability in about one-third of human colorectal carcinomas. |
Gene Details

| Gene Type | protein coding |
|---|---|
| Gene Family | Rho guanine nucleotide exchange factors, "Pleckstrin homology (PH) domain containing" |
| Description | A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]   |
| Chromosome | 22 |
| Location | 22q11 |
| Start | 23522402   |
| End | 23660224   |
| Strand | +   |
| Gene Sequence |    Download   Select all |
| Length | 137823   |
| OMIM ID | 151410    |
| HGNC ID | HGNC:1014    |
| Unigene ID | Hs.517461    |
| Ensembl ID | ENSG00000186716    |
| PharmGKB ID | PA25321    |
mRNA Information
| mRNA ID | NM_004327.3 |
|---|---|
| Exon | join(1..1875,73435..73616,80586..80690,80991..81176, 88044..88151,91168..91228,92717..92769,93270..93410, 103613..103734,104669..104837,106795..106914, 107733..107808,109153..109257,109975..110049, 112177..112274,114660..114791,129060..129119, 129960..130069,131333..131472,132523..132657, 133604..133709,134188..134350,135069..137673)   | mRNA Sequence |    Download   Select all |
| Length | 6927   |
CDS Information
| Location | 597..4412 |
|---|---|
| CDS Sequence |    Download   Select all |
| CCDS ID | CCDS13806.1 |    
Protein Information
| Protein ID | NP_004318.3 |
|---|---|
| Protein Name | breakpoint cluster region |
| Molecular Wt. (Da) | 142689 |
| Protein Sequence |    Download   Select all |
| Length | 1271   |
| Uniprot ID | P14780 |    
| Ensembl Protein ID | ENSP00000361405   |    
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| Y | Phosphorylation | 283 |
| T | Phosphorylation | 310 |
| S | Phosphorylation | 354 |
| S | Phosphorylation | 459 |
| S | Phosphorylation | 463 |
| Y | Phosphorylation | 591 |
| Y | Phosphorylation | 644 |
| Y | Phosphorylation | 283 |
| T | Phosphorylation | 310 |
| S | Phosphorylation | 354 |
| S | Phosphorylation | 459 |
| S | Phosphorylation | 463 |
| Y | Phosphorylation | 591 |
| Y | Phosphorylation | 644 |
| Y | Phosphorylation | 177 |
| Y | Phosphorylation | 177 |
| Y | Phosphorylation | 328 |
| Y | Phosphorylation | 360 |
| Y | Phosphorylation | 328 |
| Y | Phosphorylation | 360 |
| Y | Dephosphorylation | 177 |
| Y | Dephosphorylation | 177 |
| Y | Phosphorylation | 177 |
| Y | Phosphorylation | 246 |
| Y | Phosphorylation | 276 |
| Y | Phosphorylation | 279 |
| Y | Phosphorylation | 246 |
| Y | Phosphorylation | 276 |
| Y | Phosphorylation | 279 |
| S | Phosphorylation | 467;- |
| S | Phosphorylation | 467;- |
| S | Phosphorylation | 356 |
| S | Phosphorylation | 356 |
| S | Phosphorylation | 122 |
| S | Phosphorylation | 122 |
| Y | Phosphorylation | 436 |
| Y | Phosphorylation | 436 |
| Y | Phosphorylation | 598 |
| Y | Phosphorylation | 598 |
| S | Phosphorylation | 1264 |
| S | Phosphorylation | 1220 |
| S | Phosphorylation | 315 |
| S | Phosphorylation | 317 |
| S | Phosphorylation | 315 |
| S | Phosphorylation | 317 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING)      View   
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 2071 |    ERCC3 |    593 |    NP_000113.1 |    in vitro;in vivo |    9874796    |
| 2810 |    SFN |    3185 |    NP_006133.1 |    in vitro |    16045749    |
| 2885 |    GRB2 |    150 |    NP_002077.1 |    in vitro;in vivo |    81   122   929   178   913    |
| 3717 |    JAK2 |    993 |    NP_004963.1 |    in vitro;in vivo |    1   237   080   312   023   980    |
| 4301 |    MLLT4 |    1164 |    NP_001035090.1 |    in vitro;yeast 2-hybrid |    12808105    |
| 5335 |    PLCG1 |    1398 |    NP_002651.2 |    in vitro |    1383690    |
| 5921 |    RASA1 |    745 |    NP_002881.1 |    in vitro |    1383690    |
| 6714 |    SRC |    1819 |    NP_005408.1 |    in vitro |    1383690    |
| 7157 |    TP53 |    1859 |    NP_000537.3 |    yeast 2-hybrid |    16169070    |
| 7529 |    YWHAB |    3184 |    NP_003395.1 |    in vitro |    16045749    |
| 7531 |    YWHAE |    5457 |    NP_006752.1 |    in vivo |    16045749    |
| 7532 |    YWHAG |    5639 |    NP_036611.2 |    in vitro |    16045749    |
| 7533 |    YWHAH |    215 |    NP_003396.1 |    in vitro |    16045749    |
| 9094 |    UNC119 |    4927 |    NP_005139.1 |    yeast 2-hybrid |    16169070    |
| 10971 |    YWHAQ |    886 |    NP_006817.1 |    in vitro |    16045749    |
| 84966 |    IGSF21 |    11309 |    NP_116269.2 |    yeast 2-hybrid |    16169070    |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Chronic myeloid leukemia |    hsa05220 |    
| Pathways in cancer |    hsa05200 |    
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd04387 | 1052-1252  | RhoGAP_Bcr |
| cl02570 | 1052-1252  | RhoGAP superfamily |
| cd13367 | 684-877  | PH_BCR_vertebrate |
| cl17171 | 684-877  | PH-like superfamily |
| cd08686 | 913-1033  | C2_ABR |
| cl14603 | 913-1033  | C2 superfamily |
| cd00160 | 499-689  | RhoGEF |
| cl02571 | 499-689  | RhoGEF superfamily |
| cd13366 | 684-867  | PH_ABR |
| cd01228 | 707-867  | PH_BCR-related |
| smart00324 | 1067-1230  | RhoGAP |
| pfam00620 | 1068-1219  | RhoGAP |
| cd00159 | 1068-1221  | RhoGAP |
| cd04403 | 1052-1224  | RhoGAP_ARHGAP27_15_12_9 |
| cd04398 | 1052-1212  | RhoGAP_fRGD1 |
| cd04372 | 1052-1216  | RhoGAP_chimaerin |
| pfam00621 | 502-690  | RhoGEF |
| cd04395 | 1051-1216  | RhoGAP_ARHGAP21 |
| pfam09036 | Feb-72  | Bcr-Abl_Oligo |
| cl07596 | Feb-72  | Bcr-Abl_Oligo superfamily |
| smart00325 | 502-690  | RhoGEF |
| cd04379 | 1052-1252  | RhoGAP_SYD1 |
| cd04378 | 1052-1224  | RhoGAP_GMIP_PARG1 |
| cd04382 | 1067-1246  | RhoGAP_MgcRacGAP |
| cd04386 | 1051-1219  | RhoGAP_nadrin |
| cd04384 | 1051-1219  | RhoGAP_CdGAP |
| cd04377 | 1052-1213  | RhoGAP_myosin_IX |
| cd13368 | 707-868  | PH_BCR_arthropod |
| cd04374 | 1070-1216  | RhoGAP_Graf |
| cd04381 | 1052-1211  | RhoGap_RalBP1 |
| cd04409 | 1052-1219  | RhoGAP_PARG1 |
| cd04373 | 1052-1214  | RhoGAP_p190 |
| cd04385 | 1064-1219  | RhoGAP_ARAP |
| cd04408 | 1052-1214  | RhoGAP_GMIP |
| cd04391 | 1051-1231  | RhoGAP_ARHGAP18 |
| cd04400 | 1051-1216  | RhoGAP_fBEM3 |
| cd04390 | 1050-1214  | RhoGAP_ARHGAP22_24_25 |
| cd04404 | 1052-1225  | RhoGAP-p50rhoGAP |
| cd04407 | 1052-1213  | RhoGAP_myosin_IXB |
| cd04383 | 1067-1213  | RhoGAP_srGAP |
| cd04376 | 1066-1219  | RhoGAP_ARHGAP6 |
| cd04393 | 1051-1209  | RhoGAP_FAM13A1a |
| cd04406 | 1052-1213  | RhoGAP_myosin_IXA |
| cd04375 | 1051-1227  | RhoGAP_DLC1 |
| cd04389 | 1052-1213  | RhoGAP_KIAA1688 |
| cd04394 | 1087-1224  | RhoGAP-ARHGAP11A |
| cd04392 | 1087-1224  | RhoGAP_ARHGAP19 |
| cd04397 | 1052-1219  | RhoGAP_fLRG1 |
| cd04402 | 1067-1215  | RhoGAP_ARHGAP20 |
| cd04396 | 1066-1212  | RhoGAP_fSAC7_BAG7 |
| cd04388 | 1068-1239  | RhoGAP_p85 |
| cd04380 | 1014-1218  | RhoGAP_OCRL1 |
| smart00239 | 912-1016  | C2 |
| cd00030 | 913-1007  | C2 |
| pfam00168 | 913-1000  | C2 |
| cd04399 | 1052-1214  | RhoGAP_fRGD2 |
| cd13242 | 705-748  | PH_puratrophin-1 |
| cd04044 | 911-1044  | C2A_Tricalbin-like |
| cd04043 | 917-1012  | C2_Munc13_fungal |
| cd08678 | 925-1006  | C2_C21orf25-like |
| cd08391 | 923-979  | C2A_C2C_Synaptotagmin_like |
| cd13243 | 709-778  | PH_PLEKHG1_G2_G3 |
| PRK14376 | 96-168  | PRK14376 |
| cl00506 | 96-168  | Haemolytic superfamily |
| cd04041 | 911-1016  | C2A_fungal |
| cd01221 | 701-742  | PH_ephexin |
| PHA03307 | 80-387  | PHA03307 |
| PRK07003 | 80-156  | PRK07003 |
| PHA03378 | 79-175  | PHA03378 |
| PRK07764 | 72-148  | PRK07764 |
| PRK07764 | 79-153  | PRK07764 |
| PRK07764 | 75-148  | PRK07764 |
| PHA03378 | 78-152  | PHA03378 |
| PRK07764 | 78-163  | PRK07764 |
| pfam04733 | 540-684  | Coatomer_E |
| PRK12323 | 78-175  | PRK12323 |
| PRK07764 | 78-175  | PRK07764 |
| PHA03378 | 78-149  | PHA03378 |
| PRK12323 | 78-153  | PRK12323 |
| PHA03247 | 79-153  | PHA03247 |
| PRK07764 | 80-153  | PRK07764 |
| PRK12323 | 79-148  | PRK12323 |
| PRK07003 | 79-175  | PRK07003 |
| PRK12270 | 80-152  | kgd |
| PRK07764 | 69-148  | PRK07764 |
| PRK12372 | 64-131  | PRK12372 |
| PRK12323 | 80-153  | PRK12323 |
| PHA03247 | 78-171  | PHA03247 |
| PRK14951 | 78-163  | PRK14951 |
| PRK07764 | 79-153  | PRK07764 |
| PHA03307 | 78-173  | PHA03307 |
| PHA03169 | 82-146  | PHA03169 |
| PRK07764 | 80-153  | PRK07764 |
| PRK05996 | 78-153  | motB |
| PRK07764 | 80-151  | PRK07764 |
| PRK12270 | 65-153  | kgd |
| PRK12373 | 65-175  | PRK12373 |
| PHA03307 | 64-172  | PHA03307 |
| PHA03247 | 77-156  | PHA03247 |
| PRK07764 | 74-175  | PRK07764 |
| PRK07764 | 75-153  | PRK07764 |
| PHA03247 | 81-175  | PHA03247 |
| COG5038 | 911-1021  | COG5038 |
| PRK07764 | 73-153  | PRK07764 |
| PRK07003 | 78-153  | PRK07003 |
| PHA03307 | 76-156  | PHA03307 |
| PRK01297 | 72-144  | PRK01297 |
| PRK12372 | 80-150  | PRK12372 |
Ontology Information
| HPRD ID | 1704 |    
|---|---|
| Molecular Class | Serine/threonine kinase |
| Molecular Function | Metallopeptidase activity (GO:0008237) |
| Biological Process | Protein metabolism (GO:0019538)   |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P11274 | DB06616 | Bosutinib | SmallMoleculeDrug |
| P11274 | DB08901 | Ponatinib | SmallMoleculeDrug |
External Links
| ArrayExpress | GO |    
|---|---|
| ICGC | GO |    
| Cancer3D | GO |    
| COSMIC | GO |    
| NCG | GO |    
| TSGene | GO |    
| Tumor Gene Family of Databases | GO |    
| CCDB | GO |    
| G2SBC | GO |    
| Osteosarcoma Database | GO |    
| RCDB | GO |    
