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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| RPN2 | 6185 | ribophorin II | 20 | SWP1, RPNII, RIBIIR, RPN-II |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 26388988 | 2015 | Cell line : - Source : Inner Mongolia Medical University Hospital Sample Type : CRC tumor and normal tissue No. of Sample : 82 Stage : TNM stage I-IV | Immunohistochemistry,immunostaining | Unknown | - | RPN2 expression is associated with poor prognosis. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes a type I integral membrane protein found only in the rough endoplasmic reticulum. The encoded protein is part of an N-oligosaccharyl transferase complex that links high mannose oligosaccharides to asparagine residues found in the Asn-X-Ser/Thr consensus motif of nascent polypeptide chains. This protein is similar in sequence to the yeast oligosaccharyl transferase subunit SWP1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008] |
| Chromosome | 20 |
| Location | 20q12-q13. |
| Start | 35807454 |
| End | 35870026 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 62573 |
| OMIM ID | 180490 |
| HGNC ID | HGNC:10382 |
| Unigene ID | Hs.370895 |
| Ensembl ID | ENSG00000118705 |
| PharmGKB ID | PA34778 |
mRNA Information
| mRNA ID | ?NM_001135771.1 |
|---|---|
| Exon | complement(173..538) | mRNA Sequence | Download Select all |
| Length | 3498 |
Protein Information
| Protein ID | NP_001129243.1 |
|---|---|
| Protein Name | ribophorin II |
| Molecular Wt. (Da) | 31193 |
| Protein Sequence | Download Select all |
| Length | 631 |
| Uniprot ID | O43490 |
| Ensembl Protein ID | ENSP00000415481 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| T | Phosphorylation | 157 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Metabolic pathways | hsa01100 |
| N-Glycan biosynthesis | hsa00510 |
| Protein processing in endoplasmic reticulum | hsa04141 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam05817 | 2-628 | Ribophorin_II |
| cl20311 | 2-628 | Ribophorin_II superfamily |
Ontology Information
| HPRD ID | 9138 |
|---|---|
| Molecular Class | Enzyme: Glycosyltransferase |
| Molecular Function | Transcription regulator activity (GO:0030528) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.