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General Information
- Evidence
- Gene
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- Enzyme
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22272377 | 2012 | Cell line : - Source : Cathay General Hospital and the Taipei Veterans General Hospital. Sample Type : Solid fecal samples No. of Sample : 101 CRC patients Stage : - | real time RT-PCR | Down-regulation | - | RPS19 in CRC possibly involves cellular apoptosis through the BAX/p53 pathway, and the levels of fecal RPS19 may function as a prognostic predictor for CRC patients. |
| 20089989 | 2010 | Cell line : - Source : VU University Medical Center, Amsterdam, The Netherlands. Sample Type : CRC tumor and normal tissue No. of Sample : - Stage : - | Biochemical isolation to nano-LC-MS/MS analysis | Unknown | - | - |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | S ribosomal proteins |
| Description | Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S19E family of ribosomal proteins. It is located in the cytoplasm. Mutations in this gene cause Diamond-Blackfan anemia (DBA), a constitutional erythroblastopenia characterized by absent or decreased erythroid precursors, in a subset of patients. This suggests a possible extra-ribosomal function for this gene in erythropoietic differentiation and proliferation, in addition to its ribosomal function. Higher expression levels of this gene in some primary colon carcinomas compared to matched normal colon tissues has been observed. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008] |
| Chromosome | 19 |
| Location | 19q13.2 |
| Start | 41859918 |
| End | 41871416 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 11499 |
| OMIM ID | 603474 |
| HGNC ID | HGNC:10402 |
| Unigene ID | Hs.438429 |
| Ensembl ID | ENSG00000105372 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_001022.3 |
|---|---|
| Exon | join(1..372,858..928,1195..1295,9114..9297,9782..9836, 11434..11499) | mRNA Sequence | Download Select all |
| Length | 872 |
CDS Information
| Location | join(858..928,1195..1295,9114..9297,9782..9836, 11434..11460) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS12588.1 |
Protein Information
| Protein ID | NP_001013.1 |
|---|---|
| Protein Name | Ribosomal protein S19 |
| Molecular Wt. (Da) | 15929 |
| Protein Sequence | Download Select all |
| Length | 145 |
| Uniprot ID | P29279 |
| Ensembl Protein ID | ENSP00000356954 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 728 | C5AR1 | 224 | NP_001727.1 | in vivo | 11733378 |
| 2247 | FGF2 | 622 | NP_001997.5 | in vitro;in vivo | 11716516 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Ribosome | hsa03010 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam01090 | 4-139 | Ribosomal_S19e |
| cl00969 | 4-139 | Ribosomal_S19e superfamily |
| COG2238 | 3-139 | RPS19A |
| PRK09333 | 4-139 | PRK09333 |
| PTZ00095 | 3-139 | PTZ00095 |
Ontology Information
| HPRD ID | 3026 |
|---|---|
| Molecular Class | Ribosomal subunit |
| Molecular Function | Cell adhesion molecule activity (GO:0005194) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.