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General Information
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 24255681 | 2013 | Cell line : - Source : Jilin University Second Hospital (Changchun, China). Sample Type : CRC tumor and normal tissue No. of Sample : 20 Stage : - | PCR, immunohistochemistry | Up-regulation | 2.4 Fold | The protein expression of S100A3 was observed to increase by 2.4-fold in human CRC cells compared with the expression level in normal control cells. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | S100 calcium binding proteins |
| Description | The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein has the highest content of cysteines of all S100 proteins, has a high affinity for Zinc, and is highly expressed in human hair cuticle. The precise function of this protein is unknown. [provided by RefSeq, Jul 2008] |
| Chromosome | 1 |
| Location | 1q21 |
| Start | 153519805 |
| End | 153521734 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 1930 |
| OMIM ID | 176992 |
| HGNC ID | HGNC:10493 |
| Unigene ID | Hs.557609 |
| Ensembl ID | ENSG00000188015 |
| PharmGKB ID | PA34905 |
mRNA Information
| mRNA ID | ?NM_002960.1 |
|---|---|
| Exon | join(1..78,769..914,1413..1926) | mRNA Sequence | Download Select all |
| Length | 738 |
Protein Information
| Protein ID | NP_002951.1 |
|---|---|
| Protein Name | S100 calcium binding protein A3 |
| Molecular Wt. (Da) | 10049 |
| Protein Sequence | Download Select all |
| Length | 101 |
| Uniprot ID | Q99453 |
| Ensembl Protein ID | ENSP00000226382 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| A | Acetylation | 2 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00213 | Apr-90 | S-100 |
| cl08302 | Apr-90 | EFh superfamily |
| cd05029 | Jan-88 | S-100A6 |
| cd05025 | May-93 | S-100A1 |
| cd05026 | Jan-92 | S-100Z |
| cd05027 | May-90 | S-100B |
| pfam01023 | May-47 | S_100 |
| cl19180 | May-47 | S_100 superfamily |
| cd05030 | May-88 | calgranulins |
| cd05031 | May-90 | S-100A10_like |
| cd05023 | Jun-90 | S-100A11 |
| cd05022 | Mar-75 | S-100A13 |
| cd05024 | May-90 | S-100A10 |
| pfam13499 | 24-77 | EF-hand_7 |
Ontology Information
| HPRD ID | 4647 |
|---|---|
| Molecular Class | Calcium binding protein |
| Molecular Function | DNA binding (GO:0003677) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.