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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| S100A4 | 6275 | S100 calcium binding protein A4 | 1 | P9KA, 18A2, PEL98, 42A, FSP1 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 21218086 | 2011 | Cell line : - Source : Fudan University Shanghai Cancer Center, Shanghai, China Sample Type : CRC tumor and normal tissue No. of Sample : 144 Stage : - | 2D-LC-MS/MS, Western blotting, Immunohistochemistry, Realt ime RT- PCR | Unknown | - | S100A4 might serve as a powerful biomarker for LNM and a prognostic factor in CRC. Forty-three proteins were found to be differentially expressed by at least 2.5-fold in two types of CRC. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | S100 calcium binding proteins, "EF-hand domain containing" |
| Description | The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in motility, invasion, and tubulin polymerization. Chromosomal rearrangements and altered expression of this gene have been implicated in tumor metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified. |
| Chromosome | 1 |
| Location | 1q12-q22 |
| Start | 153543619 |
| End | 153545806 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 2188 |
| OMIM ID | 114210 |
| HGNC ID | HGNC:10494 |
| Unigene ID | Hs.654444 |
| Ensembl ID | ENSG00000196154 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_019554.2 |
|---|---|
| Exon | join(1..54,289..337,998..1153,1884..2188) | mRNA Sequence | Download Select all |
| Length | 512 |
CDS Information
| Location | join(1013..1153,1884..2048) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS1042.1 |
Protein Information
| Protein ID | NP_002952.1 |
|---|---|
| Protein Name | S100 calcium binding protein A4 |
| Molecular Wt. (Da) | 11597 |
| Protein Sequence | Download Select all |
| Length | 101 |
| Uniprot ID | P04792 |
| Ensembl Protein ID | ENSP00000248553 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| K | Acetylation | 7 |
| K | Acetylation | 7 |
| K | Acetylation | 35 |
| K | Acetylation | 35 |
| K | Acetylation | 18 |
| K | Acetylation | 18 |
| S | Phosphorylation | 32 |
| S | Phosphorylation | 32 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 58 | ACTA1 | 30 | NP_001091.1 | in vitro | 14640694 |
| 302 | ANXA2 | 1061 | NP_001002858.1 | in vitro;in vivo | 15788416 |
| 989 | 7-Sep | 4398 | NP_001779.3 | in vitro | 14531065 |
| 4620 | MYH2 | 1173 | NP_060004.3 | in vitro;in vivo | 12756252 |
| 4622 | MYH4 | 8873 | NP_060003.2 | in vitro;in vivo | 146 406 949 405 067 |
| 4627 | MYH9 | 1177 | NP_002464.1 | in vitro;in vivo | 152 899 399 405 067 |
| 4628 | MYH10 | 1178 | NP_005955.1 | in vitro | 9405067 |
| 4735 | 2-Sep | 3297 | NP_004395.1 | in vitro | 14531065 |
| 4856 | NOV | 1291 | NP_002505.1 | in vitro;in vivo;yeast 2-hybrid | 1 214 771 614 606 950 |
| 6271 | S100A1 | 1489 | NP_006262.1 | in vitro;in vivo;yeast 2-hybrid | 1 560 868 210 753 920 000 000 000 000 000 |
| 7169 | TPM2 | 11768 | NP_003280.2 | in vitro | 8120097 |
| 7170 | TPM3 | 1840 | NP_689476.2 | in vitro | 8120097 |
| 7917 | BAT3 | 808 | NP_004630.3 | yeast 2-hybrid | 16169070 |
| 8496 | PPFIBP1 | 4390 | NP_003613.2 | in vitro;in vivo | 11836260 |
| 9094 | UNC119 | 4927 | NP_005139.1 | yeast 2-hybrid | 16169070 |
| 10988 | METAP2 | 3522 | NP_006829.1 | in vitro;in vivo;yeast 2-hybrid | 11994292 |
| 23157 | 6-Sep | 6716 | NP_055944.2 | in vitro | 14531065 |
Pathway Information
No matching records could be found.
Structure Information
| PDB ID | 1M31 |
|---|---|
| Resolution | |
| Method | SOLUTION NMR |
| Chains | A, B |
| Molecule | Placental calcium-binding protein |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00213 | Apr-90 | S-100 |
| cl08302 | Apr-90 | EFh superfamily |
| cd05026 | Jan-91 | S-100Z |
| cd05029 | Jan-88 | S-100A6 |
| cd05025 | May-90 | S-100A1 |
| cd05027 | May-90 | S-100B |
| cd05031 | May-90 | S-100A10_like |
| cd05030 | May-77 | calgranulins |
| pfam01023 | May-48 | S_100 |
| cl19180 | May-48 | S_100 superfamily |
| cd05023 | Jun-90 | S-100A11 |
| cd05022 | Apr-75 | S-100A13 |
| cd05024 | May-90 | S-100A10 |
| cd00051 | 28-80 | EFh |
| pfam13499 | 22-79 | EF-hand_7 |
Ontology Information
| HPRD ID | 318 |
|---|---|
| Molecular Class | Calcium binding protein |
| Molecular Function | Heat shock protein activity (GO:0003773) |
| Biological Process | Protein folding (GO:0006457); Apoptosis (GO:0006915); Regulation of immune response (GO:0050776); Signal transduction (GO:0007165) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P26447 | DB00831 | Trifluoperazine | SmallMoleculeDrug |