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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| S100A6 | 6277 | S100 calcium binding protein A6 | 1 | 2A9, PRA, CABP |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 24378749 | 2014 | Cell line : HCT116, LoVo Source : - Sample Type : - No. of Sample : - Stage : - | - | Up-regulation | - | Results suggest that the cellular effects of S100A6 are mediated by the ERK and p38 MAPK pathways, and modulation of these pathways may be employed for CRC prevention and therapy. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | S100 calcium binding proteins, "EF-hand domain containing" |
| Description | The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-dependent insulin release, stimulation of prolactin secretion, and exocytosis. Chromosomal rearrangements and altered expression of this gene have been implicated in melanoma. [provided by RefSeq, Jul 2008] |
| Chromosome | 1 |
| Location | 1q21 |
| Start | 153507076 |
| End | 153508717 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 1642 |
| OMIM ID | 114110 |
| HGNC ID | HGNC:10496 |
| Unigene ID | Hs.275243 |
| Ensembl ID | ENSG00000197956 |
| PharmGKB ID | PA34908 |
mRNA Information
| mRNA ID | ?NM_014624.3 |
|---|---|
| Exon | join(1..293,882..1040,1412..1642) | mRNA Sequence | Download Select all |
| Length | 683 |
Protein Information
| Protein ID | NP_055439.1 |
|---|---|
| Protein Name | S100 calcium binding protein A6 |
| Molecular Wt. (Da) | 11340 |
| Protein Sequence | Download Select all |
| Length | 90 |
| Uniprot ID | O95243 |
| Ensembl Protein ID | ENSP00000249910 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| K | Acetylation | 40 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd05029 | Jan-88 | S-100A6 |
| cl08302 | Jan-88 | EFh superfamily |
| cd00213 | Apr-88 | S-100 |
| cd05026 | Jan-86 | S-100Z |
| cd05025 | May-86 | S-100A1 |
| cd05030 | May-74 | calgranulins |
| cd05031 | May-86 | S-100A10_like |
| cd05027 | May-77 | S-100B |
| pfam01023 | May-42 | S_100 |
| cl19180 | May-42 | S_100 superfamily |
| cd05023 | Jun-88 | S-100A11 |
| cd05022 | Apr-81 | S-100A13 |
| cd05024 | May-86 | S-100A10 |
| cd00051 | 28-77 | EFh |
| smart00054 | 52-80 | EFh |
| cl23347 | 52-80 | EFh superfamily |
| pfam13499 | 28-77 | EF-hand_7 |
Ontology Information
| HPRD ID | 5434 |
|---|---|
| Molecular Class | Calcium binding protein |
| Molecular Function | Receptor signaling complex scaffold activity (GO:0030159) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.