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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| S100A8 | 6279 | S100 calcium binding protein A8 | 1 | P8; MIF; NIF; CAGA; CFAG; CGLA; L1Ag; MRP8; CP-10; MA387; 60B8AG |
- Evidence
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 19186948 | 2009 | Cell line : Colo 201, Colo 205, HT 29,WIDR, DLD 1, HCT 116, HCT 8, LOVO, RKO, SNUC 2A and SNUC 4,CCD18CO Source : Yonsei University of College of Medicine, ATCC, Korean Cell Line Bank Sample Type : Plasma samples No. of Sample : 77 CRC and 11 colorectal adenoma patients, 21 healthy controls Stage : - | 2-D DIGE, real time RT-PCR, Western Blotting, Immunohistochemistry | Up-regulation | - | Serum levels of S100A8 and S100A9 were significantly higher in CRC patients than in healthy controls, suggesting that both proteins or only S100A8 or S100A9 might represent a new serum marker for CRC. A total of 6 colorectal carcinomas and matched nontumorous colonic mucosal tissues from 6 patients were included in the proteomic analysis. |
| 20089989 | 2010 | Cell line : - Source : VU University Medical Center, Amsterdam, The Netherlands. Sample Type : CRC tumor and normal tissue No. of Sample : - Stage : - | Biochemical isolation to nano-LC-MS/MS analysis | Up-regulation | - | - |
| 21228116 | 2011 | Cell line : Caco 2 Source : University of California, San Diego, ATCC Sample Type : - No. of Sample : - Stage : - | Flow cytometry, Immunoprecipitation, siRNA treatment, Real time PCR | Up-regulation | - | Myeloid-derived S100A8/A9 in activating specific downstream genes( Cxcl1, Ccl5 and Ccl7, Slc39a10, Lcn2, Zc3h12a, Enpp2) associated with tumorigenesis and in promoting tumor growth and metastasis. MC38 cells and MC38 cells stably expressing green fluorescent protein (GFP) were obtained from Drs. Ajit and Nissi Varki, University of California, San Diego.
|
| 22304731 | 2012 | Cell line : - Source : National Cancer Institute, National Institutes of Health. Sample Type : - No. of Sample : - Stage : - | PBMC isolation, and cell sorting, Microarray analysis, Flow cytometry, real time RT-PCR and Western blotting | Up-regulation | - | S100 proteins as useful markers for the analysis and further characterization of human MDSC. MDSC was observed in the peripheral blood from colon cancer patients in comparison with healthy controls. Total 14 CRC patient blood were included in this study 9 male and 5 female of average age 61/60 year. |
| 22634002 | 2012 | Cell line : DLD 1, LOVO, HCT 15, RKO, SW 480, WiDr, HCT 116, Caco 2, SW 620 and HT 29, THP 1 Source : ATCC Sample Type : - No. of Sample : - Stage : - | Western blot, Immunohistochemistry and immuno-fluorescence stain in coloncancer tissues. | Up-regulation | - | Increased expression of S100A8/A9 was noted in inflammatory cells of the peri- an intra-tumoral areas, along with myofibroblasts in colon cancer tissue. S100A8/A9 and myeloid cells in the tumor microenvironment play an important role in cancer invasion and progression. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | S100 calcium binding proteins, EF-hand domain containing |
| Description | The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in the inhibition of casein kinase and as a cytokine. Altered expression of this protein is associated with the disease cystic fibrosis. [provided by RefSeq, Jul 2008] |
| Chromosome | 1 |
| Location | 1q21 |
| Start | 153390032 |
| End | 153422578 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 32547 |
| OMIM ID | 123885 |
| HGNC ID | HGNC:10498 |
| Unigene ID | Hs.416073 |
| Ensembl ID | ENSG00000143546 |
| PharmGKB ID | PA34910 |
mRNA Information
| mRNA ID | XM_011509861.1 |
|---|---|
| Exon | join(1..61,32022..32184,32336..32547) | mRNA Sequence | Download Select all |
| Length | 532 |
CDS Information
| Location | join(60..61,32022..32184,32336..32476) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | - |
Protein Information
| Protein ID | NP_002955.2 |
|---|---|
| Protein Name | S100 calcium binding protein A8 |
| Molecular Wt. (Da) | 10703 |
| Protein Sequence | Download Select all |
| Length | 93 |
| Uniprot ID | P35222 |
| Ensembl Protein ID | ENSP00000344456 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 7157 | TP53 | 1859 | NP_000537.3 | yeast 2-hybrid | 16169070 |
| 7277 | TUBA4A | 1851 | NP_005991.1 | yeast 2-hybrid | 16169070 |
| 9094 | UNC119 | 4927 | NP_005139.1 | yeast 2-hybrid | 16169070 |
| 11161 | C14orf1 | 5201 | NP_009107.1 | yeast 2-hybrid | 16169070 |
| 22984 | PDCD11 | 18752 | NP_055791.1 | yeast 2-hybrid | 16169070 |
| 55791 | C1orf103 | 17975 | NP_060842.3 | yeast 2-hybrid | 16169070 |
| 64284 | RAB17 | 11468 | NP_071894.1 | yeast 2-hybrid | 16169070 |
| 64837 | KLC2 | 13917 | NP_073733.1 | yeast 2-hybrid | 16169070 |
| 84966 | IGSF21 | 11309 | NP_116269.2 | yeast 2-hybrid | 16169070 |
Pathway Information
No matching records could be found.
Structure Information
| PDB ID | 1MR8 |
|---|---|
| Resolution | 1.9 |
| Method | X-RAY DIFFRACTION |
| Chains | A,B |
| Molecule | MIGRATION INHIBITORY FACTOR-RELATED PROTEIN 8 |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| cd05030 | Mar-86 | calgranulins |
| cl08302 | Mar-86 | EFh superfamily |
| cd00213 | Mar-86 | S-100 |
| pfam01023 | May-48 | S_100 |
| cl19180 | May-48 | S_100 superfamily |
| cd05031 | Mar-81 | S-100A10_like |
| cd05025 | Mar-81 | S-100A1 |
| cd05027 | Mar-84 | S-100B |
| cd05026 | Jan-81 | S-100Z |
| cd05023 | Mar-83 | S-100A11 |
| cd05022 | Mar-91 | S-100A13 |
| cd05029 | Jan-72 | S-100A6 |
| cd05024 | Mar-81 | S-100A10 |
| smart00054 | 52-78 | EFh |
| cl23347 | 52-78 | EFh superfamily |
| pfam13499 | 31-75 | EF-hand_7 |
Ontology Information
| HPRD ID | 288 |
|---|---|
| Molecular Class | Calcium binding protein |
| Molecular Function | Cysteine-type peptidase activity (GO:0008234) |
| Biological Process | Protein metabolism (GO:0019538) |
Drug Information
No matching records could be found.