Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| S100B | 6285 | S100 calcium binding protein B | 21 | NEF; S100; S100-B; S100beta |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 17848589 | 2007 | Cell line : - Source : Tumor Bank Network established at the Centro Nacional de Investigaciones Oncologicas(CNIO). Sample Type : CRC tumor and normal tissue No. of Sample : 15 CRC patient sample Stage : - | Antibody Microarrays,Protein Labeling and Microarray Assay,Tissue Microarray Design and Immunohistochemistry | Up-regulation | 1.38 | - |
| 20628824 | 2011 | Cell line : - Source : - Sample Type : - No. of Sample : 357 postoperative colon cancer patients Stage : UICC stages II, III | Immunohistochemistry | Up-regulation | - | S100B protein overexpression as an independent predictor of early relapse in UICC stages II and III colon cancer patients after curative resection. |
| 22011044 | 2012 | Cell line : - Source : - Sample Type : Blood sample No. of Sample : 103 preoperative CRC patients Stage : - | Microarray RT-PCR and bioinformatics analysis. | Up-regulation | - | S100B, TM4SF3, and OLFM4 overexpression may affect metastatic behavior of tumor cells in Taiwanese CRC patients.
|
| 22047082 | 2012 | Cell line : - Source : Taiwanese colorectal cancer patients. Sample Type : - No. of Sample : 105 postoperative CRC patients Stage : - | Weighted enzymatic chip array (WEnCA), membrane array and direct sequencing | Up-regulation | - | EVI2B, ATP2A2, S100B, TM4SF3, and OLFM4 could be potential prognostic markers for CRC patients. Genes wchich overexpressed are EVI2B, ATP2A2, S100B, TM4SF3, and OLFM4 in CRC patient. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | S100 calcium binding proteins, EF-hand domain containing |
| Description | The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21; however, this gene is located at 21q22.3. This protein may function in Neurite extension, proliferation of melanoma cells, stimulation of Ca2+ fluxes, inhibition of PKC-mediated phosphorylation, astrocytosis and axonal proliferation, and inhibition of microtubule assembly. Chromosomal rearrangements and altered expression of this gene have been implicated in several neurological, neoplastic, and other types of diseases, including Alzheimer's disease, Down's syndrome, epilepsy, amyotrophic lateral sclerosis, melanoma, and type I diabetes. [provided by RefSeq, Jul 2008] |
| Chromosome | 21 |
| Location | 21q22.3 |
| Start | 46598618 |
| End | 46605122 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 6505 |
| OMIM ID | 176990 |
| HGNC ID | HGNC:10500 |
| Unigene ID | Hs.422181 |
| Ensembl ID | ENSG00000160307 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_006272.2 |
|---|---|
| Exon | join(1..110,2707..2845,5620..6505) | mRNA Sequence | Download Select all |
| Length | 1135 |
CDS Information
| Location | join(2708..2845,5620..5760) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS13736.1 |
Protein Information
| Protein ID | NP_006263.1 |
|---|---|
| Protein Name | S100 calcium binding protein B |
| Molecular Wt. (Da) | 10582 |
| Protein Sequence | Download Select all |
| Length | 92 |
| Uniprot ID | P07339 |
| Ensembl Protein ID | ENSP00000236671 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 309 | ANXA6 | 231 | NP_001146.2 | in vitro | 9883272 |
| 1674 | DES | 514 | NP_001918.3 | in vitro | 10510252 |
| 2670 | GFAP | 675 | NP_002046.1 | in vitro | 10510252 |
| 4137 | MAPT | 1142 | NP_001116538.1 | in vitro;in vivo | 283 351 911 264 299 |
| 5236 | PGM1 | 1389 | NP_002624.2 | in vitro | 8894274 |
| 6271 | S100A1 | 1489 | NP_006262.1 | in vivo;yeast 2-hybrid | 109 131 389 925 766 |
| 6277 | S100A6 | 237 | NP_055439.1 | in vivo;yeast 2-hybrid | 992 576 610 913 138 |
Pathway Information
No matching records could be found.
Structure Information
| PDB ID | 1UWO |
|---|---|
| Resolution | - |
| Method | SOLUTION NMR |
| Chains | A,B |
| Molecule | S100B |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| cd05027 | Feb-89 | S-100B |
| cl08302 | Feb-89 | EFh superfamily |
| cd00213 | Feb-89 | S-100 |
| cd05025 | Feb-89 | S-100A1 |
| cd05026 | Feb-92 | S-100Z |
| cd05030 | Feb-87 | calgranulins |
| cd05031 | Feb-89 | S-100A10_like |
| cd05023 | Feb-89 | S-100A11 |
| cd05029 | Feb-87 | S-100A6 |
| pfam01023 | Apr-47 | S_100 |
| cl19180 | Apr-47 | S_100 superfamily |
| cd05022 | Feb-92 | S-100A13 |
| cd05024 | Feb-89 | S-100A10 |
| cd00051 | 39-79 | EFh |
| smart00054 | 54-81 | EFh |
| cl23347 | 54-81 | EFh superfamily |
| pfam13499 | 27-78 | EF-hand_7 |
Ontology Information
| HPRD ID | 148 |
|---|---|
| Molecular Class | Calcium binding protein |
| Molecular Function | Catalytic activity (GO:0003824) |
| Biological Process | Metabolism (GO:0008152); Energy pathways (GO:0006091) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P04271 | DB00768 | Olopatadine | SmallMoleculeDrug |