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General Information
- Evidence
- Gene
- mRNA
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- Protein
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- Enzyme
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22552710 | 2012 | Cell line : - Source : Peking Union Medical College Hospital Sample Type : CRC tumor and normal tissue No. of Sample : 96 CRC patients Stage : - | Western Blotting, real timeRT- PCR, Bisulphite sequencing, SYBR-Green quantitative methylation-specific real time RT- PCR (QMSP), ELISA | Up-regulation | - | Expression of S100P protein in CRC tissues and high serum levels of S100P could be a potential novel prognostic biomarker for CRC. S100P expression was significantly correlated with the demethylation or hypomethylation of the S100P promoter. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | S100 calcium binding proteins, "EF-hand domain containing" |
| Description | The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21; however, this gene is located at 4p16. This protein, in addition to binding Ca2+, also binds Zn2+ and Mg2+. This protein may play a role in the etiology of prostate cancer. |
| Chromosome | 4 |
| Location | 4p16 |
| Start | 6693839 |
| End | 6697170 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 3332 |
| OMIM ID | 600614 |
| HGNC ID | HGNC:10504 |
| Unigene ID | Hs.2962 |
| Ensembl ID | ENSG00000163993 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_005980.2 |
|---|---|
| Exon | join(1..232,3055..3332) | mRNA Sequence | Download Select all |
| Length | 510 |
CDS Information
| Location | join(95..232,3055..3204) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS3391.1 |
Protein Information
| Protein ID | NP_005971.1 |
|---|---|
| Protein Name | S100 calcium binding protein P |
| Molecular Wt. (Da) | 10269 |
| Protein Sequence | Download Select all |
| Length | 95 |
| Uniprot ID | P08238 |
| Ensembl Protein ID | ENSP00000325875 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 177 | AGER | 2568 | NP_001127.1 | in vivo | 14617629 |
| 6273 | S100A2 | 1508 | NP_005969.1 | in vitro;yeast 2-hybrid | 15171681 |
| 6275 | S100A4 | 15914 | NP_002952.1 | in vitro;yeast 2-hybrid | 15171681 |
| 7430 | EZR | 475 | NP_003370.2 | in vitro | 12808036 |
Pathway Information
No matching records could be found.
Structure Information
| PDB ID | 1J55 |
|---|---|
| Resolution | 2 |
| Method | X-RAY DIFFRACTION |
| Chains | A |
| Molecule | S-100P PROTEIN |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00213 | Feb-89 | S-100 |
| cl08302 | Feb-89 | EFh superfamily |
| cd05031 | Feb-91 | S-100A10_like |
| cd05030 | Feb-87 | calgranulins |
| cd05026 | Feb-91 | S-100Z |
| cd05025 | Feb-89 | S-100A1 |
| cd05027 | Feb-89 | S-100B |
| cd05023 | Feb-89 | S-100A11 |
| pfam01023 | Apr-46 | S_100 |
| cl19180 | Apr-46 | S_100 superfamily |
| cd05024 | Feb-91 | S-100A10 |
| cd05029 | Apr-87 | S-100A6 |
| cd05022 | Feb-87 | S-100A13 |
| cd00051 | 27-79 | EFh |
| smart00054 | 54-81 | EFh |
| cl23347 | 54-81 | EFh superfamily |
| pfam13499 | 25-78 | EF-hand_7 |
Ontology Information
| HPRD ID | 996 |
|---|---|
| Molecular Class | Calcium binding protein |
| Molecular Function | Cell adhesion molecule activity (GO:0005194) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P25815 | DB01003 | Cromoglicic acid | SmallMoleculeDrug |