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General Information
- Evidence
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 21870058 | 2012 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 93 paired samples of rectal cancer and distant normal rectal tissue Stage : - | real time RT-PCR and immunohistochemistry | Up-regulation | - | SATB1 may play an important role in the progression of human rectal cancer, which represents a possible new mechanism underlying CRC. SATB1 expression correlated with invasive depth and tumor node metastasis (TNM) stage at both protein and mRNA levels. SATB1 protein expression in rectal cancers (44.1%) was significantly higher than that in normal tissues. |
| 22935204 | 2012 | Cell line : - Source : The Southern Swedish Regional Tumour Registry. Sample Type : CRC tumor and normal tissue No. of Sample : 557 CRC tissue sample Stage : - | Immunohistochemistry, tissue microarray, Spearmans Rho and Chi-Square tests, Kaplan Meier analysis. | Up-regulation | - | SATB1 expression is a factor of poor prognosis in SATB2 negative tumours. Role of SATB1 in colorectal carcinogenesis and suggest prognostically antagonistic effects of SATB1 and SATB2. SATB1 expression in colorectal cancer is significantly associated with beta-catenin overexpression, microsatellite stability and SATB2 expression. |
| 22972305 | 2012 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | Microarray | Up-regulation | - | PrPc is demonstrated to be involved in regulating SATB1 expression via the Fyn-SP1 pathway. STAB1 a key protein that controls tumor development and progression. |
| 24971456 | 2014 | Cell line : - Source : Department of Surgery, Peking University School of Oncology Sample Type : - No. of Sample : - Stage : - | RT-PCR, Western Blotting, Immunofluorescence Staining and Laser-scanning Confocal Microscopy, Flow Cytometry | Up-regulation | - | SATB1 may represent an important prognostic biomarker and therapeutic target for CRC. SATB1 expression was significantly higher in CRC tissues than in matched non-tumor mucosa. Sample size: 560 CRC specimes. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Homeoboxes / CUT class |
| Description | This gene encodes a matrix protein which binds nuclear matrix and scaffold-associating DNAs through a unique nuclear architecture. The protein recruits chromatin-remodeling factors in order to regulate chromatin structure and gene expression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010] |
| Chromosome | 3 |
| Location | 3p23 |
| Start | 18345806 |
| End | 18445588 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 99783 |
| OMIM ID | 602075 |
| HGNC ID | HGNC:10541 |
| Unigene ID | Hs.517717 |
| Ensembl ID | ENSG00000182568 |
| PharmGKB ID | PA34951 |
mRNA Information
| mRNA ID | XM_011533989.1 |
|---|---|
| Exon | join(1..71,24598..24832,28511..28687,29456..29582, 30355..30478,48299..48410,50673..51127,58978..59190, 67264..67419,93394..93597,94181..94276,95907..99783) | mRNA Sequence | Download Select all |
| Length | 4054 |
CDS Information
| Location | join(24622..24832,28511..28687,29456..29582,30355..30478, 48299..48410,50673..51127,58978..59190,67264..67419, 93394..93597,95907..96419) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS2631.1 |
Protein Information
| Protein ID | NP_001124482.1 |
|---|---|
| Protein Name | SATB homeobox 1 |
| Molecular Wt. (Da) | 85826 |
| Protein Sequence | Download Select all |
| Length | 763 |
| Uniprot ID | P14091 |
| Ensembl Protein ID | ENSP00000350911 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| D | Proteolytic Cleavage | 254 |
Enzyme Information
No matching records could be found.
PPi Information
No STRING Network could be found.
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1523 | CUX1 | 295 | NP_853530.2 | in vitro;in vivo | 10373541 |
| 2033 | EP300 | 4078 | NP_001420.2 | in vitro;in vivo | 14605447 |
| 2625 | GATA3 | 572 | NP_001002295.1 | in vivo | 17057718 |
| 3065 | HDAC1 | 3143 | NP_004955.2 | in vivo | 12374985 |
| 7329 | UBE2I | 9045 | NP_003336.1 | yeast 2-hybrid | 16189514 |
| 8850 | KAT2B | 6780 | NP_003875.3 | in vitro;in vivo | 16630892 |
Pathway Information
No matching records could be found.
Structure Information
| PDB ID | 1YSE |
|---|---|
| Resolution | - |
| Method | SOLUTION NMR |
| Chains | A |
| Molecule | DNA-binding protein SATB1 |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| cd11585 | 74-169 | SATB1_N |
| cl16936 | 74-169 | SATB1_N superfamily |
| cd00086 | 646-703 | homeodomain |
| cl00084 | 646-703 | homeodomain superfamily |
| pfam02376 | 363-448 | CUT |
| cl08348 | 363-448 | CUT superfamily |
| pfam02376 | 485-571 | CUT |
| cl08348 | 485-571 | CUT superfamily |
| smart00389 | 644-701 | HOX |
| pfam00046 | 646-698 | Homeobox |
| pfam09770 | 260-395 | PAT1 |
| pfam09770 | 269-364 | PAT1 |
| pfam09770 | 270-364 | PAT1 |
Ontology Information
| HPRD ID | 489 |
|---|---|
| Molecular Class | Transcription factor |
| Molecular Function | Catalytic activity (GO:0003824) |
| Biological Process | Metabolism (GO:0008152); Energy pathways (GO:0006091) |
Drug Information
No matching records could be found.