Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| SCN8A | 6334 | sodium channel, voltage gated, type VIII, alpha subunit | 12 | Nav1.6, NaCh6, PN4, CerIII |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 25804238 | 2015 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 62 Stage : - | real time RT- PCR | Down-regulation | - | - |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Sodium channels, "Voltage-gated ion channels / Sodium channels" |
| Description | This gene encodes a member of the sodium channel alpha subunit gene family. The encoded protein forms the ion pore region of the voltage-gated sodium channel. This protein is essential for the rapid membrane depolarization that occurs during the formation of the action potential in excitable neurons. Mutations in this gene are associated with mental retardation, pancerebellar atrophy and ataxia. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010] |
| Chromosome | 12 |
| Location | 12q13.1 |
| Start | 51984050 |
| End | 52206648 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 222599 |
| OMIM ID | 600702 |
| HGNC ID | HGNC:10596 |
| Unigene ID | Hs.436550 |
| Ensembl ID | - |
| PharmGKB ID | PA35009 |
mRNA Information
| mRNA ID | ?NM_001177984.2 |
|---|---|
| Exon | join(1..481,72572..72901,93982..94100,96176..96265, 96899..97027,98813..98904,109378..109599,110952..111015, 112581..112722,115225..115431,116230..116523, 131354..131716,155711..155843,161163..161401, 172311..172484,175479..175835,178673..179143, 179676..179793,180337..180491,183997..184170, 190457..190579,196350..196634,198503..198556, 199089..199226,200206..200310,204179..204449, 216090..220371) | mRNA Sequence | Download Select all |
| Length | 9612 |
Protein Information
| Protein ID | NP_001171455.1 |
|---|---|
| Protein Name | sodium channel, voltage gated, type VIII, alpha subunit |
| Molecular Wt. (Da) | 8685 |
| Protein Sequence | Download Select all |
| Length | 1980 |
| Uniprot ID | Q99558 |
| Ensembl Protein ID | ENSP00000478552 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 2775 | GNAO1 | 757 | NP_066268.1 | in vitro;in vivo | 10066808 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd13433 | 1465-1517 | Na_channel_gate |
| cl18913 | 1465-1517 | Na_channel_gate superfamily |
| pfam06512 | 991-1208 | Na_trans_assoc |
| cl05828 | 991-1208 | Na_trans_assoc superfamily |
| pfam11933 | 488-703 | DUF3451 |
| cl13384 | 488-703 | DUF3451 superfamily |
| smart00015 | 1894-1915 | IQ |
| cl23346 | 1894-1915 | IQ superfamily |
| pfam00520 | 1234-1463 | Ion_trans |
| pfam00520 | 1556-1765 | Ion_trans |
| pfam00520 | 161-410 | Ion_trans |
| pfam00520 | 787-965 | Ion_trans |
| pfam08016 | 1540-1772 | PKD_channel |
| COG0474 | 1442-1610 | MgtA |
Ontology Information
| HPRD ID | 6877 |
|---|---|
| Molecular Class | Voltage gated channel |
| Molecular Function | Signal transducer activity (GO:0004871) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| Q9UQD0 | DB00313 | Valproic Acid | SmallMoleculeDrug |