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General Information

• Evidence
• Gene
• mRNA
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Evidence Information

Pubmed ID	Year	Sample Information	Techniques	Mechanism	Fold Change	Remark
21413011	2011	Cell line : - Source : Wakayama Medical University Hospital (WMUH). Sample Type : CRC tumor and Normal tissue No. of Sample : 26 Stage I, 63 Stage II, 47 Stage III and 28 Stage IV CRC based on TNM classification Stage : TNM Stage I-IV	Immunohistochemistry, RT-PCR, Western Blotting	Down-regulation	-	CEACAM is known to be downregulated at the transcriptional level in adenoma and carcinoma. Recent reports have shown that CEACAM1 is overexpressed at protein level in colorectal cancer and correlated with clinical stage. Why colorectal cancer cells re-expressed CEACAM1 is remains unclear. CEACAM1-L dominance is important for colorectal cancer cells invasion and migration.
22469976	2013	Cell line : - Source : - Sample Type : MC38 mouse CRC cells No. of Sample : - Stage : -	-	Down-regulation	-	CEACAM1 have reduced expression in early phases of CRC development and thus functions as a tumor growth inhibitor. However, CEACAM1 is upregulated in metastatic colon cancer, suggesting a bimodal role in CRC progression. CEACAM1 may represent a novel metastatic CRC target for treatment.
23038226	2012	Cell line : - Source : - Sample Type : CRC tumor and Normal tissue No. of Sample : 68 Stage : -	-	Down-regulation	-	Loss of CEACAM1 is an early event in colorectal tumorigenesis linking the genesis of sporadic and hereditary CRC
23170281	2012	Cell line : - Source : - Sample Type : - No. of Sample : - Stage : TNM Stage I,II	-	Down-regulation	-	CEACAM1 functions are associated with two particular splicing isoforms carrying either a short (10 aa, CEACAM1-S) or a longer cytoplasmic domain (71-73 aa, CEACAM1-L). CEACAM1 is downregulated in the early stages of most epithelial cancers.
20524097	2011	Cell line : - Source : - Sample Type : CRC tumor and Normal tissue No. of Sample : 60 CRA,123 CRC Stage : Duke Stage A-D	LOH analysis, Immunohistochemistry	Mutation	-	Four somatic missense mutations, L36F, T312I, V398I and A445V, on CEACAM1 gene were detected in colorectal cancers. Have investigated the genetic alterations, including mutations and allelic loss, of the CEACAM1 gene in 17 colonic adenomas and 123 sporadic colorectal cancers. In addition, the expression pattern of the CEACAM1 protein was examined in 60 colonic adenomas and 123 sporadic colorectal adenocarcinomas. from that 12, 47, 56, and 8 cases with stage A, B, C, and D were taken. 3. all of the mutations were found in left-side colon cancers of the patients with clinical stage III.
22751559	2012	Cell line : - Source : - Sample Type : - No. of Sample : - Stage : -	Immunohistochemistry, Multivariate analysis	Unknown	-	CEACAM1 and L1 seem to have multidimensional importance for diagnosis, prognostic estimations and treatment of malignant melanoma. CEACAM1 seems to be a good tumor marker for the stratification of risk in cancer patients. CEACAM1 has an important role in the progression, invasion and metastatic potential of cancer and is involved in the tumor angiogenesis.
23376714	2013	Cell line : - Source : - Sample Type : - No. of Sample : - Stage : -	Tissue microarray and immunohistochemistry	Unknown	-	The glycoprotein, carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1), was identified as the target antigen of WL5 through immunoprecipitation and mass spectrometric analyses, which might provide a potential biomarker and therapeutic target for colorectal cancer.

Gene Details

Chromosome: 19; NC_000019.9 (43011458..43032661, complement)
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Gene Type	protein coding
Gene Family	CD molecules, Immunoglobulin superfamily / V-set domain containing, Immunoglobulin superfamily / Immunoglobulin-like domain containing
Description	This gene encodes a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within a 1.2 Mb cluster on the long arm of chromosome 19. Eleven pseudogenes of the CEA cell adhesion molecule subgroup are also found in the cluster. The encoded protein was originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it was found to be a cell-cell adhesion molecule detected on leukocytes, epithelia, and endothelia. The encoded protein mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup. Multiple cellular activities have been attributed to the encoded protein, including roles in the differentiation and arrangement of tissue three-dimensional structure, angiogenesis, apoptosis, tumor suppression, metastasis, and the modulation of innate and adaptive immune responses. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature of all variants has not been defined. [provided by RefSeq, May 2010]
Chromosome	19
Location	19q13.2
Start	42507306
End	42528509
Strand	-
Gene Sequence	>gi|568815579:c42528509-42507306 Homo sapiens chromosome 19, GRCh38.p2 Primary Assembly AAAGCTCTGGGCCCCAGGGAGGAGGCTCAGCACAGAGAGTGGAAAACAGCAGAGGTGACAGAGCAGCCGT GCTCGAAGCGTTCCTGGAGCCCAAGCTCTCCTCCACAGGTGAAGACAGGGCCAGCAGGAGACACCATGGG GCACCTCTCAGCCCCACTTCACAGAGTGCGTGTACCCTGGCAGGGGCTTCTGCTCACAGGTGAGGGGAGG ACACCCTGGGAAGGGGCGGAAAGAGGGCGCACAGAGAATGGCTAGGGTCCTCTGGGGAGGATGGAGCTCT AAGAGGGGACAGAGGGCTTCTCTTGGAGCCAAATAGGAGAGAGGACATGAAAGGGATAGAGATCATAAAA GGAAAGTCTCAGTGATCTGAAACTGTTAGTGAATAAACAATCTCCCATTTTTTACCTTTTCCAACTGAAT CATCAATGAGCAATAAATTTCAAAAACTGCTGACAATAATCACAATTTAAGTCAGCGTGACAATTAAGGA AAACATTTTAAAAGGGGCATTAAACAGAGCCCTGAGCCACCAACCTCAGATATTGGCAAATAAACCCCAG GACATGAAGAGCCCTGGGAATGCTCACTAACTCATCCACAGGAGTCTGCAGCCTATCCCAGGCACTGGGG TGCAACCAACATCACACAAATCCCTGCCCTCACGGAGCTCACGCTCTCATGGGTGGGGAAGACAGACAAG CAAAGAGATCTAGAATGTGAGGTCAGGTGTTGACAAGAGCCCTGGAGGGAACAGAGCAGAAAAAGGTCAG AAAGGGAATACCCAGGGTCTCTAGGGGAGGTGTCAGGGAAAGGATCTCCCAAGAGCACCCTGATGTGATC AAGATCTGAGGGCAGTGGGGAGGGAGCCATGCGGATCCCTGGGGAAGGGCATTCCAGAGAAATGACAAGG TCAGAGGCACTAAGGGAATGGGAGTCACACTGCTGACCTTGACCCAGTAGGACACACACACACACACACA CACACACACACACACACACACACACTCCAAGGTGGAGGGGTGAAGACACCTGCTCAGGACCCAAGGCCCC ATTTTTCTACCCTAATGCATAGGTCCCAATATTGACTGATGCTCTCTCCTCTCTCCTAGCCTCACTTCTA ACCTTCTGGAACCCGCCCACCACTGCCCAGCTCACTACTGAATCCATGCCATTCAATGTTGCAGAGGGGA AGGAGGTTCTTCTCCTTGTCCACAATCTGCCCCAGCAACTTTTTGGCTACAGCTGGTACAAAGGGGAAAG AGTGGATGGCAACCGTCAAATTGTAGGATATGCAATAGGAACTCAACAAGCTACCCCAGGGCCCGCAAAC AGCGGTCGAGAGACAATATACCCCAATGCATCCCTGCTGATCCAGAACGTCACCCAGAATGACACAGGAT TCTACACCCTACAAGTCATAAAGTCAGATCTTGTGAATGAAGAAGCAACTGGACAGTTCCATGTATACCG TGAGTATTTCCCCATGACCTCTGGGTGTTGGGGGGTTAGTTCTACTTCCCACACATGGGATTGTCAGGCC TGGGCTGTGCCTGTGTCCTCCTCTGCATTATACCCCATGTTAAGGTTTGAGCATCTAGTGCAGGACACAC TATGGGACAGACATCAAAATACCGAATGTCTTACTCTGGAGTCCTGATCCTGCAGACATTTGCTTCAGAG GAAGGACAATCTGATGTGGGTAACTTATCGAGGGGAGACCAGTCTCAATCTAGCCCCCCGGGACCCTCCT GGTGAACATGTCCCTAAGAAAGACCCAGTAGGACTCAGTCAGGGTCTGGCCTGAAGGGCCTTCTGGGATC CTCACAGACAAGCTCAGCCCTGGGAATCCCCTGCTCCAAAACACTATCCCAAGGTTCTCAACTCCTGGTG ACCCTGAGGAGCCTGGGCCAGGGCTAGATTGTGGCCTCCTGGGCAGGGCTGACTAGGAACAAGAATTTGA GCTATCCGAGGGCTGTGGCTCCTGGAGCTGGTAACCAGCCAGGGTTCAGGCACTAGAGCCTCATTTGGGC AAGGATGGAGCCTCATCCTTCACCTTAGTCTCAGCCTGGAGAGGACAGATGGACAAGCTCCCCAGGCCAT CAGCCAACTGCCCTGGGGGCTTAGGAGATGCCATAGGAAGTTTACCATCCCCAGGAGGAGGAACAGAGGA GACAGGATGCTCCTGAAAGCTCCTTGTCCACCAGGGATCAGGCTGAGAGGCACTCTCAGGGAATCCAACA ACAATAGATGCTGCGGCCGGGAGCGGTGGCTCACGCCTGTAATCCCAGTACTTTGGGAGGCCGAGGTGGA TGGACTATGAGGTCAGGAGTTCAAGACCAGCCTGACCAACATGGTGAAATGCCGTCTCTACTAAAAATAC AAAAAAATTAGCCGGGCATGGTGGTGCGTGCCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAAT TGCTTGAACCTGGGAGGCAGAGGTTGCAGTGAGCCAAGATCACACCACTGCACCCTAGCCTGGGTGACAG AGCGAGACTCCATCTCAAAAAAATAAAATAAAATAAGATTGTTTATTTGGGCAGCTCCCCTATGCAGAGC TGAGGTCAAATAATTATAAATATTTTAAGGTTAATTCACAGACCACAAGATAAGCCAAAACCATTAACCA TTTATACTATTTCACTGAGGGGAAACTGAGCCACATGGCAATAAATACAGTCACTATATCAAGGTCACAC AGACCGTAACTGGAAGATCAGTTACAGGAGATTTGTCTTCAGCCACAGTCTTAACCTCTCCTCTACTCCA GGGGCCTTATTTGGCATCTGTGGACCCCAATACCAGAGTTGGTTCAGTTCCTTTCTTCTTAGGCATCTGC AGCCCAGAGGGGAGATCCTGGTCTGGGGAGTGAGATCAAATGGAGAATTAACCAAGTTTTATTCTGGAAC TTATTCAACAATTAGAGTCAGTGTCAGAAATGTTCAGGCCTGGGTCAGGTGTGGTGGCTCACACCTGTAA TCCCAGCACTTTGGGATGCCAAGGTGGGCGGATCACTTGAGGTCAGGAGTTCAAGACCAGCCTGGCCAAC ATGGTGAAACCCCATCTCTACTAAAAATACAAAAAAAATTAGTCGGGCATGGTGGTGCGTGCCTCTAATC CCAGCTACTTGGGATGCTGAGGTGGTAGAATCGCTTGAACCCAGGAGGCAGAGGTTGCAGTGAGCCAAGA TCATGTCACTGTGCTCCAGCCTGGGAGACAGAGTGAGACTCTATCTCAAAAAAAAAAAAAAAAAATGTTC AGGCCTATCCCCTCAGACCCACACCTCTGCTCCCTGGACTTGAAATCCTGTGTTTCCTGATGTGTTGGTG TCACTCCCACAGGAGGATAAAGGAAAGGACTTTGCTTTCTCTCCTCACTCACACCCTGCACCAGCCAGGG CCCAATATGAAACACACACTCAGTAGTTCTCTCACGAATGAATGAATGATTGAATGATCCATAACCTCTT TAGAGACTGGATCTGGTTGCAGAATCCTGGGAGGTTCTTGCCATACCTGCTCCCCATCCCTCCAGAGACT GAGACCCATGTTCCATCCCCTGACCATCTACCCCTAAAGCCACCCCAAGTACCATATTTCATGTGACTCT GGGGCTGCTCGGCTGTGGGAAGGTTTTCAGGGCTCCCTGGTCTTGGTTCTGGGACACCAGAGGCTCCTGG TTGCTGGGGTCTCTAAGGTCACTTAGCCCCCACTGCTCACTGTCATGGGCATCTCTGACTCTCTCTGCTC CTCCATGTCCTCATTTTCCTCTCCTTTTATCCCAGCTGAACTGCACAGTTTCCTCCACCCTTAGGCCTTT CCCAGACACTCCGTCTAACAAGGTTGACTGTCCTGTTCCCTTCCCGCTCACACTGTGGCCAGGCCCACCT CCCAGGCAATAGGAAAGGCACAGAAATGAGCCCAGAGCAGCCACCCCTGCCAGGTCCATCATAAGCCACT GTCCCCACGTCCCTCAGTGAGGCTGACATGTGGAACAGGCCAGGGGACAGGGACGAGCGACTCCTCCATA CACTCTCTATACTGACTCACCAGGGGATCAGAGGCAGAAGGACAGGTCTGCAGTCCCCAAAGCCCATGGG CTCATTTCACCCATTTGACTCCTAACTCCATCCCTGTTCTGCTGTGGGCTCACATCCTCTAGTGGTTCCT GGGACCTTCCCCAGGTAGAGCTAGCCAGGCAGGTGCTGTCTGATGGGTTTGCTGCCCATTCCACCTACAC CTGTGTCCTCATGATGACACCATTGTCATAAGGTGGGATCTCTCAGACAGGGAGATGCATTAGCCACTGG TGTCTCACTTAGACTCTGCCCAATTTGGATGAATTTGGTCAAACTCTAGTTGTGTTTCCTGAGGTTGAGA GAAAAGGAAGAAAGCATTTCACATGACTGTTTTGGGTTCCTCTTTTTACCTGAATTTCCACAGGAATTTG TAACATAGAACTCTTTCTAAATTTACTAACATAACATACATCACTTCTCCTCATATGGCATCGTTTCTCT CTTAATGCAATTGAGAACTCTCAGATATCCTTTCTGACAAGTTCTGTCTTCCTAACAGGACCCATGAGTC CCTTCTACCCAGGGAGTCACTGATTTCAAACTGACTTCAGCATCTTTCTTTGATCATAACATGATCCTAC TGGACTTCAGAGCTTGGTTTAAGAGTTTATCACGCTCTCTAGAGAATATTCCTCTTATTAATTGGTGTTA GATCCAGAGTATTAATAACAATTTTCACAAATGGAATAATTTAACTTCTCAAATTTATATCCCAGATCTA CCAAACACACACGGTCCATGAGGGTCAGGCTTTCAGCAAGTTCATGCTCCTTCCGTTCCACTAGCTGGTT ATTCTGCATTTGCAAAAAACCCACATATTTCAGAAAAGATCCACAGTGTCATCATCTGCTCTTTTCAGGG GGAAAAGGGACATTAAAGACCAAAGACAAGGAACGTAGATATGCTGTTAAATCCAGGCAGCCCCTGCCTG TCACCCTCACTCTTTTCTAGATCATTCCTTGGACTCTGCTCTATCTTTAGGGGGTCACTGGCTCAAGTCA GTCATCATCAAACACCTGGGAAAAACTGCCCCACCTTGTGGTTCTGCTGCCTGACGACTGAGCTACCTTC AGGCTTGCCCCTGGTGTCCCCTGTTATTTCTGCTGAAACATACAGTCCCAGGCCAGGCTGCTCAGTATCC TCAGGGTTTAAGGACAATAGGAAGTCCCATCATCACCCATCTCTAGGATGTCCTCAGACAGGGAAGCTGC AGAGAAAACACACCTAGTGGGGCAAAGTAGGACTGTGAAGCTGGAAGGGACCCAGCACCTGTATGTTCCA GGTGAGGACCCACAGGTGGGTCAGGCAGGCATCAGCCAGTCAGGGAAGGACCAGAAGTGCCTGGGGCTGT GACTCCCAGTCCTCGGTCTGTCCACGACCCAACACTGCTGCTCAGTTCACACTTGAGAAAGTCTGTGCTT CTCTCACACAGAGCAGGCGGCCTCACGGTCTCTGAGCCCTCAGATCATTGCACATCTGTCTTGTGAAACA CACACTTGCCATGGGCTTTTAGGGACTTGGGTTGGCTGAGAGGTGGGGAGATGCCAACTCTGATTGAAAA ATGCCCGGACGGAATCCCAGCACTTTGGGAGGCCGAGGCGGGCAGATCACGAGGTCAGGAGGTCGAGACC ATCCTGGCTAACAGTGACCATCCTGGCTAAAATACAAAAAACTAGCCGGGCATGGTGGCATGCACCTGTA GTCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCGCTTGAACCCGGGAGGAAGAGGTTGCAGTGAGCCA AGATCGTGCCACTGCACCCCAGCCTCAGCAACAAAGCGAGACTCTGTCTCAAAAAAAAAAAGAAAGAAAG AAAAATGCCCAGCCAGGCACGGTGGCTCAGGCCTGTAATCCCAGCACTTTGAGAGGCCGAATCGGGCGGA TTGCCAGAGCTCAGGAGTTTGAGACCAGCCTGGGCAACACGGTGAAACCCCGTCAGGCATGGTGGCATGT GCCTGTAATCCCAGCTACTCAGGAAGCTGAGGCAGGAGAATTGCTTGAATCCAGGAGGTGGAGGTTGCAG TGAGCCGAGATCGTGCCATTGCACTCCAGCCTGGGTGACAGAGCGAGGCTCCATCTCCAAAAAAAATAAA TAAATAAGAAAAGAAAAATGCCTGTGGAGGAATCAAAGGTGCCACACAGGGCAATCTTCTCTCTGTTTTC TGCATAGCGGAGCTGCCCAAGCCCTCCATCTCCAGCAACAACTCCAACCCTGTGGAGGACAAGGATGCTG TGGCCTTCACCTGTGAACCTGAGACTCAGGACACAACCTACCTGTGGTGGATAAACAATCAGAGCCTCCC GGTCAGTCCCAGGCTGCAGCTGTCCAATGGCAACAGGACCCTCACTCTACTCAGTGTCACAAGGAATGAC ACAGGACCCTATGAGTGTGAAATACAGAACCCAGTGAGTGCGAACCGCAGTGACCCAGTCACCTTGAATG TCACCTGTGAGTATCTTCTGTTCCTCTGTGGCCCAGGCTGCCAGCCCAAATCCACGCAGCCAGAGGCCAG GCCTCTCAGTCCCTCTCAGGTCTAAGGACGCAGACCCTTAACCCTGGACACCCAGGCTGGCCATGACTTC CTTTCCCCAGGCAAACCTGGGCAGCCCCAGCCTGAACCAAGAATAGGAGGGGAGAGGCTGCTCCTGTCCT GGGAGGCTCAGGGTCCACAGCCTGTGATGGGAGAAACAGGTGAATGTCTCAGACCCAGACTCAGTGGACA CAATGGAGGTTTGGTTAGGACTTCAGGGTTGTGACTTAGTAGAGAGGAACACTGTGGCCCTTCTCCAGAC CAGCAGCTTCCCCTTCCCTCTGATGACATCACCTGTGGCTTTATTCTCTTTGCTCCAGATGGCCCGGACA CCCCCACCATTTCCCCTTCAGACACCTATTACCGTCCAGGGGCAAACCTCAGCCTCTCCTGCTATGCAGC CTCTAACCCACCTGCACAGTACTCCTGGCTTATCAATGGAACATTCCAGCAAAGCACACAAGAGCTCTTT ATCCCTAACATCACTGTGAATAATAGTGGATCCTATACCTGCCACGCCAATAACTCAGTCACTGGCTGCA ACAGGACCACAGTCAAGACGATCATAGTCACTGGTAAGTAATTCCTGGAGCATCAACACTAAGATCTGGG GTACAAGCTTTCTGGTTTTCAAATAGGAGCAGAGAAGAAATTTTCTTTTGCAGCCTGTATCCAACAGGCA CAAACAAGTCCAAATTCTCCCCTGAACCCTCTCAATTCATCTGTGCAGACTCTCTTCCCTTTGTTTTTCT GATTTCTCACAGCTGACCTTAGGTCCAGCCTGGAATGTGGGGAGGGGGTTCTCTCAGCCCCAGAAAGCCC CGTGTAGCAGGAGGGGCTTCACAGAGGGGGAAGCAGAAAGGGTCCTCAAGGTCAATTTGCTTCTGTCACT AACATGTCCCTTTCTGTAACTTCTTGGCCTTCTTTTACCTATTCCATGAGATATAAGGAATATGTGAGGT TTTAAAACAGACTCACAATAGTTTTCCCTAAATGAGAGAAGGAAATGCCCTTCATCAGGGATGAGCAGCT CAGACTCTGCTCCCTGCTCTACTCCCGGCTTGCCCGGTGATTGGCTCTGCCCTGACCCCATGTGGGGTAG GACGCAGGTGTGTGCAGAAGGTGTCCAGGTGGCCTGTCATGAATCCAGCTAAATCAAGATGGCAGTCAAT GGCTGGGCGCTGTGGTTCATGCCTGTGATCCCAGTACTTTGGAAGGCCGAGGTGAGAGGATCACCTGAGG TCAGGAGTTCGAGACCAGCCTGACCAACATGGCAAAACTCCATCTCTACTAAAAATACAAAAAAAAAAAT TTAGCCAGGCATGGTTGCACATGCCACTAGGCATGCCACTAGGGAGGCTGAGGCACAAGAATCACTTGAA CCTGGGAGGCAGAGGTTGCAATGAGCCGAGATGGCACCACTGCACTCCAGCCTGGACAACACAGAGAGAC TCTGTCTCAAAAACTAAATAAATAAATAAATAAAGGCAGTCAACACCTGAGCCTCCCCTGGGTCAGGCTG CCTCCCTGAGCTTGTCCTGGCTCTGAAGTCACCAGCTGTATGAGGCTGTGGGCACAGCACATGGGATAGC ACAGAGCACAGCGAGTGACCCACACTTGGAGAAATCGGGAGATTCAGCCACAGGGGCTCTGCATTGGAGA GAATGGGCAATGCCAAACAGCGTGTATTTGTAGAGAAGGTAAGAATATCAGCCTTTTGTTAACACTGTGC CTACTCTAGGAATCTCCTTCACCGTGATATTCTATCCACAGACCAGGAAGTAAAACTCCTCTTTACAGTG GGAAATCCTTCGGATTGGAACTCCAGATAGTAAGGTCATGAAGACTGGATGGGGCATCATCATTCCCTAA AAAATTATTTAATGAAAAAAAACACTACCTTCCCTTTTGTATGTAAAGTGACAGTCACAGGAAGGATGCC TGATCACAGCTCCAGGAAAGGGTCAGTGGGAGGCCAGGCACAGTGGCTCACGCCTGTAATCCCAGCACTT TGGGAGGCTGAGGCGGGTGGATCATGAGGTCAGGAGATCAAGACCATCCTGGCTAACATGGTGAAACCCC GTCTCTACTAAAAATACAAAAAATTAGCTGGGCATGGTGGCACATGCCTTTAGTCCCAGCTACTCGGGAG GCTGAGGCAGGAGAATGGCTTGAACCCGGGAGGCAGAGCTTGCAGTGAGCTGAGATCATGCCACTGCATT CCGGCCTGGGTGACAGAGCGAGACTCCGTCTGAAAAAAAAAAAAAAAAAGTCAGTGGGAAAAACATTCTA CCTGATGATGAGGTTGCTCGGTCTGTGCGCTGAGAAGAAGATTCCAAGTGGAGATATAGAGATATCCAGA GGGTCACTCTGAGACGATCTGGGGTCAGGAGGGAGGTGCAGCCCTCTCCTTACAATTCATCACCTGAACA AAGACACTCGACCTTCTGCAGAGGGTCAGGGCTATCCCCTGGTTGGTGACCTTTGCACAGCTCACTGTGG GACCTGAGAGCTGGCTAAAATCTCAGGGAAAGGAGCATAGCCCTAGGCCCCAGGCCCCAACCCTATTCTC AGTAGGTTATCTCAGATACTCTGCTTGTCCACAGAGCTAAGTCCAGTAGTAGCAAAGCCCCAAATCAAAG CCAGCAAGACCACAGTCACAGGAGATAAGGACTCTGTGAACCTGACCTGCTCCACAAATGACACTGGAAT CTCCATCCGTTGGTTCTTCAAAAACCAGAGTCTCCCGTCCTCGGAGAGGATGAAGCTGTCCCAGGGCAAC ACCACCCTCAGCATAAACCCTGTCAAGAGGGAGGATGCTGGGACGTATTGGTGTGAGGTCTTCAACCCAA TCAGTAAGAACCAAAGCGACCCCATCATGCTGAACGTAAACTGTAAGTGACTCCTCACCCCTTCCTATAT GTCCCTCTAGGATTACTCTGTCAATGGTGTGCAAAATGGATAAAACTCACAGGAGGCAGAATATCAATGA AGAGACCATTATAGCAAACAGAATTGCAAAGTGGTTAAGAGCTCAGCTCAGGCCGGGCACAGTGGCTCAC GCCTGTAATCCCAGCAGTTTGGGAGGCCAAGGCGGGCGGATCACGAGGGCAGGAGATCGAGACCATCCTG GCTAATATGGTGAAACCCCGTGTCTACTAAAAATACAAAAAAAAATTAGCCGGGCATGGTGGCGGGCGCC TGTAGTCCCAGCTACTCGGGAGGCTGAGGCGGGAGAATGGCGTGAACCTGGGAGGCGGAGCTTTCAGTGA GCCGAGATGGTGCCACTGCACTCCAGTCTAGGCAACAGAGCAAGACTCTGTCTCAAAAAAAAAAAAAAAA AAAGAGCTCAGGCTCTGAATCAAATATACATATACTTAGTTGGTTTTTTTTGGTTGGTTGGGTTTTTTTG TTTGTTTTGTTGTTTTGAGACAGGGTCTCACTCTGTCACCCAGGCTGGAGTGCTGTGGTGTGATCAAAGC TCACTCCCGCCTCAATCCCCTGGGTTCAAGCAATCCTGCCACCTCAGCCTCCAGAGTAGCTGGGACTACA GGTTGCACCACCATGCCTGGCTAAGTTTTTAAGTTTTTTTGTAGAGTTGGGGTTTCACTGTGTTGCCCAG GCTGGTCTCAATCTCCTGGTCTCAGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGAATGAGCCACTCTG CCCACCCCGTATTTAACTATTCTAAGTACCTCTCATACAGATGGAAGCATGCAATATTTGTCCTTTTGTG TCTGGCTTACTTCATTTAGCACAATGTCTTCAAGCTCCATCTATGTTGTAGAATGTATCAGAATTTCATT CCTTTTGGAGACTGAATAATATTATGCTGTGTAGATAGATACATCACATTTTGCTTATCCACTCATCCAT CTATGGACAGTTAGGTTGCTTCCACCTTTTGGCTATTATGAATAATGCTATTACAAACATGGGTATACAA ATATCTGTTCAAATCCCTGCTTTCAGTTCTTTTAAATAGATACTCAGAAGTGGAATTGCTGGATCAAATG GTAATCCTGTTTAATTTTGAAGAACCATCATACCATTTTCCACAGTGGCTATACCATTTCACATTCCCAC CAGCAATGCACTAGAGTTCCAATTTCTCTACATCTTCAAAAACATTTGTTGCTTTCTGGTTTTGTTTTGT TTTTTATAATGGCCATCCTAATGGTTATAAGGTGGTATATCATTGGAGTTTTGATTTGCACTTCCCTAAT GATTAGCAATATTTAGCATCTTTTCATGTGCTTATTTGCCATTTATCTTCTTTGGAGAAATGTTTATTCA AGTCCTTTGCCCATGTTTTAATTAGGTTGTTTGGGGATTTTTGGTTGAGTTGCAGTAGTTCTTTATATAT TTTGGATATTAATCCCTTATCAGATATATGATTCTCAAATATTTTCTCCCATTCTATAAGAAGTCTTTTC ACTTTTGTGATAATGTGCTTTGATACACAAAAGCTTTTAATTTTCATTAAGTCCAATTTCTCTACTTCTT CTTTCGTTGCCTATGCTTTTAGTGTCATAGCCAAGAAATCATTGCCAAATTCAATGTTCCAAAGTTTTCA CTCTATCTTCCAAGAGCTTTATAGTTTTAGCTCTTACATTTAGGTCTTTTATGCATTTTGAATTAATTTT TATATATGGTGTTACATAAAGGTTCAATTTCATTCTTTTGCATGGATATCCAGTTTCTTCAATGCCATTT GTTGAAAAGACTATCCTTTCCCCACTGAATGATCTTGGCACCCTTGTCAAAAAACATTTGGCTATGTATG CAAACATTTCTTTCTGGGCTCTATATTTTATTCCACTGGTTTCTATTTCTTTTTGCCAGTACCATACTGT TTTGATTACTGTAGCTTTTGGATTTTGTTTGTTTGTTTTATTGTTGTTGTTTGGGTTTTTTTGTTTTGTT TTGTTTTTTTGCTTTTCTTTGTAGAGATGGCGTTTCACCATGTTGCCAAGGCTGGTCTCAAACTCCTGAG CTCAAGCAATCCACCCGCCTCCACCTCCCAAAGTGCTAAGATTACAGGTGTGATGATTACCATAGCTTTG TAAAAAATTTTGAAACCAGGAAGTGTGAGCCCTTCAACTTTGTTCTTTTTCAAGATTGCTTTGGCTATCC ATGGTCCCTTCAGAGTCTATATAAATTTTAGAATGAATTTTTCTATTTCTGCAAAAAATATTACTGGAAT TTTGATAGAGATTGCACTGAATCTGTAGATCACTTTGGGTAGTACTGTCATCTTAACAATATTAAGTCTT CTAATCCATGAAAATGGGGTGTCTTTTCAATTTATGTCTTATTTAATTTCTTTTGGCAATGTTTTGTATT TTCAGGGTACAAATCTTTCACCTCTTTGGTTAAGTTTATTTCTAAGTATTTTTAAAGCTCTTATAAATAG AATTTTTTTCTTAATTTTCCTTTGAATTGTTATTAGTATACAAAAATACAACTGATTTTTGCATGTGGAT TTTGTATCCTGCCACTTTGCTAAATTTATTATTCTAACAGTTTTTTTGTGGAATCTCTAGGGTTTTCTAT ATATAAGTTAGTGTATTCTGCAAACAGGTATAATTTTACTTCTTTCCAATCTAGATGCTTTTTTTTTCTT GCCTAATTGTTCTGTCTAGGTCTTCCAATACTACATTGAATAGAAATGGCAAAAGCAGGCATCCTTGTCT TGTTCTTGATCTTAAAGGAAAAGTTTTCAATCTTTCACCATTGACTATGATGGTAGCTGGGGGTTTTCAC ATGTAGCATTTATTATGTTGAGAATTTCCTTCTATTCCTAGTTTCAGTGTTTTTTAGCATGAAAGAATGT TGAATTTTGTCAAATGCTTTTATCGACTCATTTTCATTACTGGTTATAGGTCTATTCAGATTTTCTATTT ATTCATGATTCTATCATGGCAGGTTTTGTGTTTCTAGGAATTTGTTCATTTCATCCAGGTTATCCAATTT GTTGGCATTCAATTACTCATAGTACTCTTATAATCCTTATTATTTCTGCAGAATTAGTAGTAATGTTTTA CTTTCATTTCTGACTTTAGTAATTTGAATCTTCTTTCTTTCTTAGTCAATCTAATTAACAGTTGTCAATT ATAGTGATCTTTTTTGAAGAACAACTTTTTTTTTTCGGTTTGAGACAGGTTCTCACTCTGTCACCGAGGC TGATCATGGCTCACCACAGCCTCAACTTCCCGGGTTCAAGCAATCCTCCTGCTTCAGCCTCCTGGGTAGC TGAAACTACAGACAAGCACTACCACCTCCGGCTAATTTTTGTAATTTTTTGTAGAGACAGGGTTTCACCA TCTTGCCCAGCTGGTCTCAAATTCCTGAGCTCAAGTGATACACCTGCCTCAGCCTCCCAAATTGCTGGGA TTACAGTCATACACCACTGTACCTGGCCTACAGTTATAAATTTCTTTCTTGCACAAGATTCTTAACTACT CTGAGCCTCGGATTCCTCAACCGAAAATTGCACTGTGAATGCCTGCTCCATAGTATTGCACGGGTTTGGG GTTTTTGTTTTGTTTTTGAGACAGGGTGTCACTCTGTCACCCAGACTGGAGTGCAGTGGTGCAAACACAG CTCACTGCAGCCTCAACCTCCTGGGCTCAAGCAATTCCCTCACCTTAGCCTCCTAAGTAGTACATACTAC CACATCTGGCTAATTTATTTTTATTTTTGTTTTCAGAGAGACAGAATCTCACCATGTTACCCAGGCTGGA CTCGAACTCCTGGGCTCAAGCAATCCTCCCATCTGTTTCCCAAAGTGCTGAGATTACAGGTGTGAGCCAC CACGCCTGGCCCCATAGTGTTATTTTAAAGATTTAATGTAATAATAAACCTTCAGCAAAACACCACACAC AGAGGAAATGTTTCATAAATGTTAGCTGCTATTACTACTACTATTATCATTAGCCTTGAAATCAGGTAGT CCTAGGGTCAAATCTCAGATCCACCTCTCACTAGCCATCTGACTTTAGGTAAGCCTTTTACCACTCTAAG CTTCCATTTTTTCATGTTTAAAATGGAAATAATGTCTACCTGACAGCACTATTTTATGGATCAAATAAGA TACATGTAAAGCATTTAGCAGCACAGGGCCTGGCACACAGGAAGTACTCCACAAAAGTAGCTAACATAGC ATTAGTCACCAGCCTGAGTTGACTGGTGAGGGTTAAGCCCCAAATAGTTGCAACAGATATAAACAAGAAA TAGGCTAGACACAGTGGCTCACACCTGTAATCCCAACATTTGGGAGGCCGAGGCTGGAGGATCTCTTGAG CCCAGGAATCCAAGACCAGCCTAGGCAATATAGTGGAACCCTATCTCTACAAAAATTATTTTTTTTTAAT TAGCCAGGTGGGTGGGCGTGGTGGCTCACGCCTGTAATCCCAACACTTTGGGAGGTTGAGGCAGGCGGGT CACCTGAGGTCGGGAGTTCAAGACCAGCCTGACCAGGATGGAGAAACCCCGTCTCTACTAAAAATACAAA ATTAGCCAGGCGTGGTGGCGCATGCCTGTAATCCCAGCAATTCAGGAGGCTGAGGTAGGAGAATCGCTTG AACCTGGGAGGCAGAGGTTGCAGTGAGCCGAGATCACGCCATTGCACTCTAGCCTAGGCAACAAGAGCAA AACTCGGTCTCAAAAAAAAAAAAAAGAAAGAAAAAAATTAGCCAGGTGTGGTGGCATGTGCTTATAGTCT CAGCTACTGAGGAGACTGAGGTGGGAGGATCACTTGATCCCAAGAGGCTACAATGAGCCATGATTGTGCC ACTGCACTCCAGCCTGGGTGATAGAGTGAGAACCTGCCTCAAAAAAAAAAAAAAAAAAAAAGAAGAAGAA GAAATAGATGCAAAAGGTATTATTTATATATTATATATATATATATATATATATATGGAGGGAGAAGCAT TATACAAGAAACCCACTGGGACATGGCTATGATCAAATATGGGAAAGGGGGAAAAAAGGAGGTAAAGCAA AGTCTCAAGCCTGGTATGTTAGTTTCCATCTACTGAGATACAGTGAAGATGGGATTAAACATACGAGATA ATTTATTGGGGAAAATGCCTGTGAGGGAAAGTAAGGCGAGAGTGAGAGGAACCTCAGACCATGATGCAGA TCTGATTCCTGTGGAAGAGAAAGAGAGGAAGGAAGTTTTAGATTGAAGTGCAGTTTTTGTTTGTTTGTTT TTTGAGACAGAGTCTCACTCTGTTGCCCAGGCTTGAGTGCAGTAGTGTGATCTCGGCTCACTGAAACCTC TGCCCCCCGGGTTCAAGCGATTCTCCTGCCTCAGCCTCTCAAGTAGCTGGGATTATAGGCACCTGCCACC GCACCCAGCTAAATTTTGTATTTTTAGTAGAGATAGGGTTTCACCATCTTGGCCAGGCTGGTCTTGAACT CCTGACCTCGTGATCCACCCGCCTCAGCCTCCCAAAGTTCTGGGATTACAGGCGTCAGCCACCGCGCCCG GCCTGCAGTGCAGTTCTAAGAGCATTTCTGCAAGGCTGACAGGGAGTCCTCCAGCCATTCACACTTCAGA ATAAAACAGTCACACAAAACTGGGCTAGCTTTCATACCCCTGCTGGGAGCCTGTGGGAAGCCAGTTCTCT ATGCAAAAGAGGTGGTGAATTCAGAATGCACCAACTGCCACAACTGAGACACTGAGAAAAAGATGCAACC ACGAAAAAGGTGGAAAGTTCTAATCACATACAAAATAGCAATCAGCCTTTCTCATATTTCAAAGCCTTAA AAATGGCTGAGCGCAGAAAAGCCAGGGTGGAATTGGCAGAAGAGAGATCATCAACCTAGAAACATGGTGA CTGGGGTTGGGCGCAGTGGCTCACGCCTATAATCCAAGCACTTTGGGAGGCCGAGGCAGGCGGATCATGA GGTCAGGAGTTCAAGACCAGTCTGACCAATATGGTGAAACCCCGTCTCTACTAAAAAAATACAGAAATTA GCCAGGTGTGGTGGCACGTGCCTGTAGTCCAGCCTGAGGCAGGAGAATCGCTTGAACCTGGGAGGCGGAG GTTGCAGTGAGCCAAGATCATGCTACTGCACTCCAGCCTGAGAGACAGAGCAAGACTCTGTCTCAAAAAA AAAAAAGAAAAGAAAAAAAGAAACATGGTGATTGAAAAAAAAAAATTGCAAGGATATAGTTAGCTAATCA CCTTCCAGCAACCTTCCCACAACGAAACTGTATTCCTTGAAGGAACAATTAGAAACTACTTCATTCTGAG AGTTGTTTCCCAGCCCCCATTGTAAAATAATTTCACTTTCATTTCTTCTCCTCTTTTCTCTCCATGACAG ATAATGCTCTACCACAAGAAAATGGCCTCTCACCTGGGGCCATTGCTGGCATTGTGATTGGAGTAGTGGC CCTGGTTGCTCTGATAGCAGTAGCCCTGGCATGTTTTCTGCATTTCGGGAAGACCGGCAGGTATGATGGC CTTTCCTCTTGTTCTGTTTCCTCCAAGGCTGACTGCCATGCTTGGGAGAGGGAAAGAATTCTTTGCCTGT CTCTGGGCCTGGATCTCATACTCCTCCCACTAAACTCCTGCTTCTCGGCACTAATTCCCACAGGTTTCCT CTTCCCTGGTCTTCGTGCTCCCTGTCTCCCATTATCTCTTGGACATGGGTATTCCAATCCCCATCTAATC TAGAGGAAGAGACTCAAGTATGTTCCTCTGTCCCCTAGTCAGGGAAAGCAAGGTCTAAGAAGGAAAACAA ATGAAAAAATGAAAGAAGCAGCAGGAGAAAGCAAGTCATGTGCTCTGTTGACCACATTGGAAGAGGAGGG AGAAATAGCATAGGAAGAGAACCTAAGAGAAAGCAAAAACAACCAAAGTCCTCTTGAACAATAAATAGAG AAAAAAAAAAAAGTATCTACCCCGGAAAACAAAATGGGAAAGGTTTTAAGGATAGAAGTAGGCACAGAAG CAGCTGATAAAGAATGAAATGAAATGTGAACATCCAGCAAACAGGAAAAGAGTAAACACTAGAAGGGATT GTAGTTAGACTGAAGAACGAGGCCCTCAGAAGAAAGGCAGTATGAACATCAAGGACTCTAAGGAATTACC TGCTCACAGTGTCCTTCCTAACTTACGGAACAAAGATCCTGTGCTTGGGAATAGCAGTCACAGTTTCTGA TATTTATTTAGGGCAAGCGACCAGCGTGATCTCACAGAGCACAAACCCTCAGTCTCCAACCACAGTAAGT AAAGCCACTTACCCCAGTGAGAACTGGTATGTTCCACCACGTGCCCTCCCCTGGCAGGGAATCCTGGATT CCCAAACCACTCCCTCCCTTCTGAATTTTCACAGAAAGGATCTCTATTTCCCAACCCTAAGGTGGCATAG GTCTTCCCACCCTTCCTAGCCACAGGAGTCCCCTGAGACACATCTGAGGAGAGAGGCTCACTCTGCCTAG GCCAGGCAGGCCTGAGGAAGATCCCATGTTTCCAGGAGCCATTTCCTCAGCCTTACTCCTTCCGCCTCCT GCCTCTATTACGGATGTGGGCACTCTCCCTTGGTGAGACTTTCCTTATCTTGTGGGTGCTGTGGGTGCTA CAAGTCTCAATGCCCCTCCTTGCCACTGGAGCATGTTGCTGAGAAACACATCTGGGCAAAAATCAAGGCC TTGTGAACTGGTAGAACTCTTCACAAGTGGATTGTGGCCTCCTGTGGTTCTGCCCCTGCCCCCTCTCTGG TACTAACATGCTGGGTCTGGACCATACACTCTGAGGGAAGTAAATTCCTTAACTGATCCTTAAACTCCCC ACCCTCCAACTGCCACCTCCTTCAGCTAGAATCACCTGAAGTCAGCTTTGCATTTCCATGGATCGCTAAC TCTTCTTTTGCTTCTCCAGCTCAGGACCACTCCAATGACCCACCTAACAAGGTAAGCATAGCCGGTTTTC ATGGGCTTATTTTCTCATGGAAATGATTCTGTGTAGAATTGATTATTCATGAAGACACAATGTAACATCA AGTTTGGGTTAATGTTCCTCAGTGCAACAACAAAGACGTATTTGTAATCACTCCCATGAGTCTACTTTGC AGCAAGAACATGCATTTTGGAATTATTCCCATCCTGTGTCTGAATACTGGATGTGACTCTTAGTAGCTCT GTGACCCTTGTCAAGTAACTTAACCTCTTTGATCATCAGCTTTGTCATCTGTAAAATGGGCATTCTGCCT ACTTCAAAGAGAAGTTGAAGGGATTAAACGAGATAACCTACAAAGAGCACCCAGCACAATGGCCTAAAAA AGGAAGGCACTGAATCATTCTCACTCCCCTACCTTCAGTCTGATCCTGCTCTTATTGTCAAAAGGATAAT TTCAATTTTAATAGATCTGAGATCCTGTTTTTTAATAATAATTTTATAGAATTTTTCATTTTATGGCCAG GCACAGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCAGGTGAAACACAAGGTCAGGAGA TCGAGACCATTCTGGCTAACATGGTGAAACCCCAGCTCTACTAAAAATACAAAAAAATTAGCCAGCTGTG GTGGCGGGCGCCTGTAGTCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATGGCGTGAACCCAGGAGGTGG AGTTTGCAGTGAGCCAAGATTGCGCCATTGCGCTCCAGCCTGGGCGACAGAGGGAAACTCTGTCTCAAAA AAAAAAGAAGTTTTCATTTTACCTTTTCAATAGAGCAAACATACATACTGAAAAGTGCTAAATCATAATT ATACTTTCACAATGTATGAACTTTCACAAGTTGAACACACCCAGGTAAGCAGCACCCAAATCATGAAATA CTACATGACCTCCCCTTAAAAAGAGACCCTTCCAGCCAGGTGCAGTGGCTCACACCTGTAATCCCAGCAC TCTGGGAGGCCAAGGCAGGTGGATCACTAGAAGTCAGGAGTTCTAAACCAGCCTGGCCAACATAGTGAAA CCTTGTTCTACTAAAAATACAAAAAATTAGCCGGGCGTGGTAGTGGATGCCTGTAATCCCAGCTACTTGG GAGGCTGAGACAGGAGCATCGCTTGAACCCGGGAGGCAGAGCTTGCAGTGAGCCGAGATCGTGCCATTGC ACTCCAGCCTGGGCGACAGAGCGAGACTCCGTCGCAAAAAAAAAAAACTCTACCAGTCACTTCCCTCCAA AGAGGAGTAACCACTATCCTGACTTCTAATGCTCCAGATTAGTATTGCTTGGTTTTGTTCCTATCTAAAG GAGAAATAAAACATATCCTTATATGTGGCTTCTTCAACATTGCTTTGTGAGACTCATCCATATTGTATGT ATTTGTGGTTTGCTGGTTCTCATTGCTGCATTATCCTATCCCATTGCATATATACCATAATTTCTCTCTT CTAATGATCATTCATCAGGAGGTCAGCAAGCAGAGAATGGGTAACAACAAAAGCCCTTCTCCAGAGCTAA AATTTCAAAATGGTAACAGCTTGTGGTGCTGAATCACACCAGGCAAGGTGAGGCCCTGCCCTGTGTCACT GACTTAACTGATCATTATTTGTGCTTTTCAGATGAATGAAGTTACTTATTCTACCCTGAACTTTGAAGCC CAGCAACCCACACAACCAACTTCAGCCTCCCCATCCCTAACAGCCACAGAAATAATTTATTCAGAAGTAA AAAAGCAGTAATGAAACCTGTCCTGCTCACTGCAGTGCTGATGTATTTCAAGTCTCTCACCCTCATCACT AGGAGATTCCTTTCCCCTGTAGGGGTAGAGGGGTGGGGACAGAAACAACTTTCTCCTACTCTTCCTTCCT AATAGGCATCTCCAGGCTGCCTGGTCACTGCCCCTCTCTCAGTGTCAATAGATGAAAGTACATTGGGAGT CTGTAGGAAACCCAACCTTCTTGTCATTGAAATTTGGCAAAGCTGACTTTGGGAAAGAGGGACCAGAACT TCCCCTCCCTTCCCCTTTTCCCAACCTGGACTTGTTTTAAACTTGCCTGTTCAGAGCACTCATTCCTTCC CACCCCCAGTCCTGTCCTATCACTCTAATTCGGATTTGCCATAGCCTTGAGGTTATGTCCTTTTCCATTA AGTACATGTGCCAGGAAACAAGAGAGAGAGAAAGTAAAGGCAGTAATGCCTTCTCCTATTTCTCCAAAGC CTTGTGTGAACTCACCAAACACAAGAAAATCAAATATATAACCAATAGTGAAATGCCACACCTTTGTCCA CTGTCAGGGTTGTCTACCTGTAGGATCAGGGTCTAAGCACCTTGGTGCTTAGCTAGAATACCACCTAATC CTTCTGGCAAGCCTGTCTTCAGAGAACCCACTAGAAGCAACTAGGAAAATCACTTGCCAAAATCCAAGGC AATTCCTGATGGAAAATGCAAAAGCACATATATGTTTTAATATCTTTATGGGCTCTGTTCAAGGCAGTGC TGAGAGGGAGGGGTTATAGCTTCAGGAGGGAACCAGCTTCTGATAAACACAATCTGCTAGGAACTTGGGA AAGGAATCAGAGAGCTGCCCTTCAGCGATTATTTAAATTATTGTTAAAGAATACACAATTTGGGGTATTG GGATTTTTCTCCTTTTCTCTGAGACATTCCACCATTTTAATTTTTGTAACTGCTTATTTATGTGAAAAGG GTTATTTTTACTTAGCTTAGCTATGTCAGCCAATCCGATTGCCTTAGGTGAAAGAAACCACCGAAATCCC TCAGGTCCCTTGGTCAGGAGCCTCTCAAGATTTTTTTTGTCAGAGGCTCCAAATAGAAAATAAGAAAAGG TTTTCTTCATTCATGGCTAGAGCTAGATTTAACTCAGTTTCTAGGCACCTCAGACCAATCATCAACTACC ATTCTATTCCATGTTTGCACCTGTGCATTTTCTGTTTGCCCCCATTCACTTTGTCAGGAAACCTTGGCCT CTGCTAAGGTGTATTTGGTCCTTGAGAAGTGGGAGCACCCTACAGGGACACTATCACTCATGCTGGTGGC ATTGTTTACAGCTAGAAAGCTGCACTGGTGCTAATGCCCCTTGGGGAAATGGGGCTGTGAGGAGGAGGAT TATAACTTAGGCCTAGCCTCTTTTAACAGCCTCTGAAATTTATCTTTTCTTCTATGGGGTCTATAAATGT ATCTTATAATAAAAAGGAAGGACAGGAGGAAGACAGGCAAATGTACTTCTCACCCAGTCTTCTACACAGA TGGAATCTCTTTGGGGCTAAGAGAAAGGTTTTATTCTATATTGCTTACCTGATCTCATGTTAGGCCTAAG AGGCTTTCTCCAGGAGGATTAGCTTGGAGTTCTCTATACTCAGGTACCTCTTTCAGGGTTTTCTAACCCT GACACGGACTGTGCATACTTTCCCTCATCCATGCTGTGCTGTGTTATTTAATTTTTCCTGGCTAAGATCA TGTCTGAATTATGTATGAAAATTATTCTATGTTTTTATAATAAAAATAATATATCAGACATCGA    Download   Select all
Length	21204
OMIM ID	109770
HGNC ID	HGNC:1814
Unigene ID	Hs.512682
Ensembl ID	ENSG00000079385
PharmGKB ID	-

mRNA Information

mRNA ID	NM_001184816.1
Exon	join(1..199,1110..1469,6308..6586,6989..7243,16031..16160, 17590..17621,19282..21204)
mRNA Sequence	>634 AAAGCTCTGGGCCCCAGGGAGGAGGCTCAGCACAGAGAGTGGAAAACAGCAGAGGTGACAGAGC AGCCGTGCTCGAAGCGTTCCTGGAGCCCAAGCTCTCCTCCACAGGTGAAGACAGGGCCAGCAGG AGACACCATGGGGCACCTCTCAGCCCCACTTCACAGAGTGCGTGTACCCTGGCAGGGGCTTCTG CTCACAGCCTCACTTCTAACCTTCTGGAACCCGCCCACCACTGCCCAGCTCACTACTGAATCCA TGCCATTCAATGTTGCAGAGGGGAAGGAGGTTCTTCTCCTTGTCCACAATCTGCCCCAGCAACT TTTTGGCTACAGCTGGTACAAAGGGGAAAGAGTGGATGGCAACCGTCAAATTGTAGGATATGCA ATAGGAACTCAACAAGCTACCCCAGGGCCCGCAAACAGCGGTCGAGAGACAATATACCCCAATG CATCCCTGCTGATCCAGAACGTCACCCAGAATGACACAGGATTCTACACCCTACAAGTCATAAA GTCAGATCTTGTGAATGAAGAAGCAACTGGACAGTTCCATGTATACCCGGAGCTGCCCAAGCCC TCCATCTCCAGCAACAACTCCAACCCTGTGGAGGACAAGGATGCTGTGGCCTTCACCTGTGAAC CTGAGACTCAGGACACAACCTACCTGTGGTGGATAAACAATCAGAGCCTCCCGGTCAGTCCCAG GCTGCAGCTGTCCAATGGCAACAGGACCCTCACTCTACTCAGTGTCACAAGGAATGACACAGGA CCCTATGAGTGTGAAATACAGAACCCAGTGAGTGCGAACCGCAGTGACCCAGTCACCTTGAATG TCACCTATGGCCCGGACACCCCCACCATTTCCCCTTCAGACACCTATTACCGTCCAGGGGCAAA CCTCAGCCTCTCCTGCTATGCAGCCTCTAACCCACCTGCACAGTACTCCTGGCTTATCAATGGA ACATTCCAGCAAAGCACACAAGAGCTCTTTATCCCTAACATCACTGTGAATAATAGTGGATCCT ATACCTGCCACGCCAATAACTCAGTCACTGGCTGCAACAGGACCACAGTCAAGACGATCATAGT CACTGATAATGCTCTACCACAAGAAAATGGCCTCTCACCTGGGGCCATTGCTGGCATTGTGATT GGAGTAGTGGCCCTGGTTGCTCTGATAGCAGTAGCCCTGGCATGTTTTCTGCATTTCGGGAAGA CCGGCAGCTCAGGACCACTCCAATGACCCACCTAACAAGATGAATGAAGTTACTTATTCTACCC TGAACTTTGAAGCCCAGCAACCCACACAACCAACTTCAGCCTCCCCATCCCTAACAGCCACAGA AATAATTTATTCAGAAGTAAAAAAGCAGTAATGAAACCTGTCCTGCTCACTGCAGTGCTGATGT ATTTCAAGTCTCTCACCCTCATCACTAGGAGATTCCTTTCCCCTGTAGGGGTAGAGGGGTGGGG ACAGAAACAACTTTCTCCTACTCTTCCTTCCTAATAGGCATCTCCAGGCTGCCTGGTCACTGCC CCTCTCTCAGTGTCAATAGATGAAAGTACATTGGGAGTCTGTAGGAAACCCAACCTTCTTGTCA TTGAAATTTGGCAAAGCTGACTTTGGGAAAGAGGGACCAGAACTTCCCCTCCCTTCCCCTTTTC CCAACCTGGACTTGTTTTAAACTTGCCTGTTCAGAGCACTCATTCCTTCCCACCCCCAGTCCTG TCCTATCACTCTAATTCGGATTTGCCATAGCCTTGAGGTTATGTCCTTTTCCATTAAGTACATG TGCCAGGAAACAAGAGAGAGAGAAAGTAAAGGCAGTAATGCCTTCTCCTATTTCTCCAAAGCCT TGTGTGAACTCACCAAACACAAGAAAATCAAATATATAACCAATAGTGAAATGCCACACCTTTG TCCACTGTCAGGGTTGTCTACCTGTAGGATCAGGGTCTAAGCACCTTGGTGCTTAGCTAGAATA CCACCTAATCCTTCTGGCAAGCCTGTCTTCAGAGAACCCACTAGAAGCAACTAGGAAAATCACT TGCCAAAATCCAAGGCAATTCCTGATGGAAAATGCAAAAGCACATATATGTTTTAATATCTTTA TGGGCTCTGTTCAAGGCAGTGCTGAGAGGGAGGGGTTATAGCTTCAGGAGGGAACCAGCTTCTG ATAAACACAATCTGCTAGGAACTTGGGAAAGGAATCAGAGAGCTGCCCTTCAGCGATTATTTAA ATTATTGTTAAAGAATACACAATTTGGGGTATTGGGATTTTTCTCCTTTTCTCTGAGACATTCC ACCATTTTAATTTTTGTAACTGCTTATTTATGTGAAAAGGGTTATTTTTACTTAGCTTAGCTAT GTCAGCCAATCCGATTGCCTTAGGTGAAAGAAACCACCGAAATCCCTCAGGTCCCTTGGTCAGG AGCCTCTCAAGATTTTTTTTGTCAGAGGCTCCAAATAGAAAATAAGAAAAGGTTTTCTTCATTC ATGGCTAGAGCTAGATTTAACTCAGTTTCTAGGCACCTCAGACCAATCATCAACTACCATTCTA TTCCATGTTTGCACCTGTGCATTTTCTGTTTGCCCCCATTCACTTTGTCAGGAAACCTTGGCCT CTGCTAAGGTGTATTTGGTCCTTGAGAAGTGGGAGCACCCTACAGGGACACTATCACTCATGCT GGTGGCATTGTTTACAGCTAGAAAGCTGCACTGGTGCTAATGCCCCTTGGGGAAATGGGGCTGT GAGGAGGAGGATTATAACTTAGGCCTAGCCTCTTTTAACAGCCTCTGAAATTTATCTTTTCTTC TATGGGGTCTATAAATGTATCTTATAATAAAAAGGAAGGACAGGAGGAAGACAGGCAAATGTAC TTCTCACCCAGTCTTCTACACAGATGGAATCTCTTTGGGGCTAAGAGAAAGGTTTTATTCTATA TTGCTTACCTGATCTCATGTTAGGCCTAAGAGGCTTTCTCCAGGAGGATTAGCTTGGAGTTCTC TATACTCAGGTACCTCTTTCAGGGTTTTCTAACCCTGACACGGACTGTGCATACTTTCCCTCAT CCATGCTGTGCTGTGTTATTTAATTTTTCCTGGCTAAGATCATGTCTGAATTATGTATGAAAAT TATTCTATGTTTTTATAATAAAAATAATATATCAGACATCGAAAAAAAAAA    Download   Select all
Length	3187

CDS Information

   

Location	join(136..199,1110..1469,6308..6586,6989..7243, 16031..16160,16882..16934,17590..17621,19282..19401)
CDS Sequence	>gi|296317313:136-1242 Homo sapiens carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) (CEACAM1), transcript variant 5, mRNA ATGGGGCACCTCTCAGCCCCACTTCACAGAGTGCGTGTACCCTGGCAGGGGCTTCTGCTCACAGCCTCAC TTCTAACCTTCTGGAACCCGCCCACCACTGCCCAGCTCACTACTGAATCCATGCCATTCAATGTTGCAGA GGGGAAGGAGGTTCTTCTCCTTGTCCACAATCTGCCCCAGCAACTTTTTGGCTACAGCTGGTACAAAGGG GAAAGAGTGGATGGCAACCGTCAAATTGTAGGATATGCAATAGGAACTCAACAAGCTACCCCAGGGCCCG CAAACAGCGGTCGAGAGACAATATACCCCAATGCATCCCTGCTGATCCAGAACGTCACCCAGAATGACAC AGGATTCTACACCCTACAAGTCATAAAGTCAGATCTTGTGAATGAAGAAGCAACTGGACAGTTCCATGTA TACCCGGAGCTGCCCAAGCCCTCCATCTCCAGCAACAACTCCAACCCTGTGGAGGACAAGGATGCTGTGG CCTTCACCTGTGAACCTGAGACTCAGGACACAACCTACCTGTGGTGGATAAACAATCAGAGCCTCCCGGT CAGTCCCAGGCTGCAGCTGTCCAATGGCAACAGGACCCTCACTCTACTCAGTGTCACAAGGAATGACACA GGACCCTATGAGTGTGAAATACAGAACCCAGTGAGTGCGAACCGCAGTGACCCAGTCACCTTGAATGTCA CCTATGGCCCGGACACCCCCACCATTTCCCCTTCAGACACCTATTACCGTCCAGGGGCAAACCTCAGCCT CTCCTGCTATGCAGCCTCTAACCCACCTGCACAGTACTCCTGGCTTATCAATGGAACATTCCAGCAAAGC ACACAAGAGCTCTTTATCCCTAACATCACTGTGAATAATAGTGGATCCTATACCTGCCACGCCAATAACT CAGTCACTGGCTGCAACAGGACCACAGTCAAGACGATCATAGTCACTGATAATGCTCTACCACAAGAAAA TGGCCTCTCACCTGGGGCCATTGCTGGCATTGTGATTGGAGTAGTGGCCCTGGTTGCTCTGATAGCAGTA GCCCTGGCATGTTTTCTGCATTTCGGGAAGACCGGCAGCTCAGGACCACTCCAATGA    Download   Select all
CCDS ID	CCDS54273.1

Protein Information

      

Protein ID	NP_001020083.1
Protein Name	Carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
Molecular Wt. (Da)	46757
Protein Sequence	>634 MGHLSAPLHRVRVPWQGLLLTASLLTFWNPPTTAQLTTESMPFNVAEGKEVLLLVHNLPQQLFG YSWYKGERVDGNRQIVGYAIGTQQATPGPANSGRETIYPNASLLIQNVTQNDTGFYTLQVIKSD LVNEEATGQFHVYPELPKPSISSNNSNPVEDKDAVAFTCEPETQDTTYLWWINNQSLPVSPRLQ LSNGNRTLTLLSVTRNDTGPYECEIQNPVSANRSDPVTLNVTYGPDTPTISPSDTYYRPGANLS LSCYAASNPPAQYSWLINGTFQQSTQELFIPNITVNNSGSYTCHANNSVTGCNRTTVKTIIVTE LSPVVAKPQIKASKTTVTGDKDSVNLTCSTNDTGISIRWFFKNQSLPSSERMKLSQGNTTLSIN PVKREDAGTYWCEVFNPISKNQSDPIMLNVNYNALPQENGLSPGAIAGIVIGVVALVALIAVAL ACFLHFGKTGSSGPLQ    Download   Select all
Length	464
Uniprot ID	P04075
Ensembl Protein ID	ENSP00000336927

Post-translational Modification Information (Source : HPRD)

Residue	Type	site
Y	Phosphorylation	493
Y	Phosphorylation	520
S	Phosphorylation	508

Enzyme Information

No matching records could be found.

PPi Information

(Click to view network : Source STRING)      View   

                                             

Interactant Gene ID (Source: HPRD)	Gene Symbol	HPRD ID	Ref Seq ID	Technique	References
1956	EGFR	579	NP_005219.2	in vitro;in vivo	15467833
2316	FLNA	2060	NP_001104026.1	in vitro;in vivo;yeast 2-hybrid	16291724
3643	INSR	975	NP_000199.2	in vitro	108   057   337   592   607   000   000   000   000   000

Pathway Information

No matching records could be found.

Structure Information

No matching records could be found.

Domain Information

ID	Location	Description
cd05774	36-140	Ig_CEACAM_D1
cl11960	36-140	Ig superfamily
cd05740	146-233	Ig_CEACAM_D4
cl11960	146-233	Ig superfamily
cd05741	48-140	Ig_CEACAM_D1_like
cd05740	340-415	Ig_CEACAM_D4
cl11960	340-415	Ig superfamily
pfam13895	240-318	Ig_2
cl11960	240-318	Ig superfamily
cd00096	344-404	Ig
pfam00047	342-398	ig
pfam13927	327-400	Ig_3
cd05728	244-303	Ig4_Contactin-2-like
pfam13895	327-414	Ig_2
cd00096	255-313	Ig
cd04967	244-305	Ig1_Contactin
pfam13895	146-233	Ig_2
cd05850	244-305	Ig1_Contactin-2
cd04968	244-304	Ig3_Contactin_like
cd05736	256-305	Ig2_Follistatin_like
pfam13927	241-303	Ig_3
pfam13927	146-219	Ig_3
cd05848	255-305	Ig1_Contactin-5
cd05732	326-406	Ig5_NCAM-1_like
pfam07686	329-414	V-set
cd05729	250-311	Ig2_FGFR_like
cd05716	377-396	Ig_pIgR
cd00096	163-221	Ig
cd05851	246-303	Ig3_Contactin-1
pfam07686	35-140	V-set
cd05742	284-317	Ig1_VEGFR_like
cd04969	88-121	Ig5_Contactin_like
cd05751	145-234	Ig1_LILRB1_like
pfam00047	252-301	ig
cd05852	252-316	Ig5_Contactin-1
cd05743	163-219	Ig_Perlecan_D2_like
cd05856	250-311	Ig2_FGFRL1-like
cd05714	327-414	Ig_CSPGs_LP
cd05857	251-311	Ig2_FGFR
cd05750	356-407	Ig_Pro_neuregulin
cd05737	340-400	Ig_Myomesin_like_C
cd05728	175-219	Ig4_Contactin-2-like
cd05754	330-396	Ig3_Perlecan_like
cd05876	163-219	Ig3_L1-CAM
cd05745	163-225	Ig3_Peroxidasin
cd05856	343-400	Ig2_FGFRL1-like
cd05734	85-124	Ig7_DSCAM
smart00408	342-403	IGc2
smart00408	251-305	IGc2
smart00410	157-233	IG_like
smart00410	244-304	IG_like
smart00409	244-304	IG
pfam07679	317-408	I-set
smart00410	342-414	IG_like
smart00409	342-414	IG
smart00409	157-233	IG
pfam07679	241-305	I-set
smart00408	161-222	IGc2
PHA02785	193-404	PHA02785
pfam07679	161-233	I-set
PHA02826	213-417	PHA02826
PHA02826	106-217	PHA02826

Ontology Information

   

HPRD ID	70
Molecular Class	Adhesion molecule
Molecular Function	Lyase activity (GO:0016829)
Biological Process	Metabolism (GO:0008152); Energy pathways (GO:0006091)

SNP Information

View SNP Geneview Report   

Drug Information

Uniprot ID	DrugBank ID	Name	Type
P13688	DB00113	Arcitumomab	BiotechDrug

External Links

                                 

ArrayExpress	GO
ICGC	GO
Cancer3D	GO
COSMIC	GO
NCG	GO
TSGene	GO
Tumor Gene Family of Databases	GO
CCDB	GO
G2SBC	GO
Osteosarcoma Database	GO
RCDB	GO