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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| CCL2 | 6347 | chemokine (C-C motif) ligand 2 | 17 | MCP1, MCP-1, MCAF, SMC-CF, GDCF-2, HC11, MGC9434 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 19706805 | 2009 | Cell line : SW1116p21, SW1116v3 Source : Cancer Institute/Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College (CAMS&PUMC), Beijing. Sample Type : CRC tumor and normal tissue No. of Sample : 245 Stage : TNM Stage I-IV | Immunohistochemistry | Up-regulation | - | CCL2 and SNCG, combined with clinicopathologic features, may be used as accurate predictors of liver metastasis in colorectal cancer. |
| 26020569 | 2015 | Cell line : - Source : - Sample Type : Blood sample No. of Sample : 45 Stage : - | Peripheral blood mononuclear cells (PBMC) culture,cytometric bead array | Up-regulation | - | The serum level of CCL2 in patients with colorectal cancer may have prognostic value. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Chemokine ligands, "Endogenous ligands" |
| Description | This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Chemokines are a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4. [provided by RefSeq, Jul 2013] |
| Chromosome | 17 |
| Location | 17q11.2-q2 |
| Start | 32582296 |
| End | 32584222 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 1927 |
| OMIM ID | 158105 |
| HGNC ID | HGNC:10618 |
| Unigene ID | Hs.303649 |
| Ensembl ID | ENSG00000108691 |
| PharmGKB ID | PA130413151 |
mRNA Information
| mRNA ID | ?NM_002982.3 |
|---|---|
| Exon | join(1..149,946..1063,1446..1927) | mRNA Sequence | Download Select all |
| Length | 760 |
Protein Information
| Protein ID | NP_002973.1 |
|---|---|
| Protein Name | chemokine (C-C motif) ligand 2 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 99 |
| Uniprot ID | O14543 |
| Ensembl Protein ID | ENSP00000330341 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| A | Proteolytic Cleavage | 27 |
| A | Proteolytic Cleavage | 27 |
| A | Proteolytic Cleavage | 27 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1462 | VCAN | 340 | NP_004376.2 | in vitro | 11083865 |
| 2532 | DARC | 192 | NP_001116423.1 | in vitro;in vivo | 1 367 939 117 416 740 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| AGE-RAGE signaling pathway in diabetic complications | hsa04933 |
| Chagas disease (American trypanosomiasis) | hsa05142 |
| Chemokine signaling pathway | hsa04062 |
| Cytokine-cytokine receptor interaction | hsa04060 |
| Herpes simplex infection | hsa05168 |
| Influenza A | hsa05164 |
| Malaria | hsa05144 |
| NOD-like receptor signaling pathway | hsa04621 |
| Rheumatoid arthritis | hsa05323 |
| TNF signaling pathway | hsa04668 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00272 | 34-91 | Chemokine_CC |
| cl00134 | 34-91 | Chemokine superfamily |
| smart00199 | 31-90 | SCY |
| cd00169 | 34-91 | Chemokine |
| pfam00048 | 29-90 | IL8 |
| cd00274 | 35-94 | Chemokine_CX3C |
| cd01119 | 34-91 | Chemokine_CC_DCCL |
| cd00271 | 35-98 | Chemokine_C |
Ontology Information
| HPRD ID | 10398 |
|---|---|
| Molecular Class | Chemokine |
| Molecular Function | Molecular function unknown (GO:0005554) |
| Biological Process | Cell growth and/or maintenance (GO:0008151) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P13500 | DB01055 | Mimosine | SmallMoleculeDrug |
| P13500 | DB01406 | Danazol | SmallMoleculeDrug |