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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| CCL18 | 6362 | chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) | 17 | DC-CK1, PARC, AMAC-1, DCCK1, MIP-4, CKb7 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23433718 | 2013 | Cell line : - Source : First Affiliated Hospital, Sun Yat-Sen University Sample Type : CRC tumor and normal tissue No. of Sample : 371 CRC patient samples Stage : - | Immunohistochemistry | Up-regulation | - | A high CCL18 level might be an independent biomarker for predicting better survival of patients with CRC. 118 samples (31.8%) showed a high CCL18 expression level. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Chemokine ligands |
| Description | This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for naive T cells, CD4+ and CD8+ T cells and nonactivated lymphocytes, but not for monocytes or granulocytes. This chemokine attracts naive T lymphocytes toward dendritic cells and activated macrophages in lymph nodes. It may play a role in both humoral and cell-mediated immunity responses. |
| Chromosome | 17 |
| Location | 17q11.2 |
| Start | 36064272 |
| End | 36071481 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 7210 |
| OMIM ID | 603757 |
| HGNC ID | HGNC:10616 |
| Unigene ID | Hs.143961 |
| Ensembl ID | ENSG00000275385 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_002988.3 |
|---|---|
| Exon | join(1..138,6176..6287,6680..7210) | mRNA Sequence | Download Select all |
| Length | 798 |
CDS Information
| Location | join(72..138,6176..6287,6680..6770) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS11306.1 |
Protein Information
| Protein ID | NP_002979.1 |
|---|---|
| Protein Name | chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) |
| Molecular Wt. (Da) | 7855 |
| Protein Sequence | Download Select all |
| Length | 89 |
| Uniprot ID | P10809 |
| Ensembl Protein ID | ENSP00000340019 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 9094 | UNC119 | 4927 | NP_005139.1 | yeast 2-hybrid | 16169070 |
| 11161 | C14orf1 | 5201 | NP_009107.1 | yeast 2-hybrid | 16169070 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Chemokine signaling pathway | hsa04062 |
| Cytokine-cytokine receptor interaction | hsa04060 |
Structure Information
| PDB ID | 4MHE |
|---|---|
| Resolution | 2.1 |
| Method | X-RAY DIFFRACTION |
| Chains | A,B,C |
| Molecule | C-C motif chemokine 18 |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00272 | 30-86 | Chemokine_CC |
| cl00134 | 30-86 | Chemokine superfamily |
| smart00199 | 30-85 | SCY |
| pfam00048 | 24-85 | IL8 |
| cd00169 | 30-82 | Chemokine |
| cd01119 | 30-82 | Chemokine_CC_DCCL |
| cd00271 | 27-82 | Chemokine_C |
| cd00274 | 25-85 | Chemokine_CX3C |
| cd00273 | 31-82 | Chemokine_CXC |
Ontology Information
| HPRD ID | 3336 |
|---|---|
| Molecular Class | Chemokine |
| Molecular Function | Transcription factor activity (GO:0003700) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.