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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| CCL21 | 6366 | chemokine (C-C motif) ligand 21 | 9 | SLC, exodus-2, TCA4, CKb9, 6Ckine, ECL |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23760102 | 2013 | Cell line : - Source : Tissue Bank of the Sixth Affiliated Hospital of Sun Yat-Sen University (Guangzhou, China) Sample Type : CRC tumor and normal tissue No. of Sample : 12 paired primary CRC tissues and normal colorectal tissues Stage : - | Western blotting, tissue microarray, Immunohistochemistry | Up-regulation | - | High expression of CCL21 is an independent and useful biomarker for predicting longer survival of stage III/IV CRC patients. Overexpression of CCL21 was signi?cantly correlated with larger tumor diameter, more mucinous carcinoma or signet ring cell carcinoma and poor tumor differentiation. Patients with high expression of CCL21 had a higher overall survival rate in comparison to patients with low expression. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Chemokine ligands, "Endogenous ligands" |
| Description | This antimicrobial gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. Similar to other chemokines the protein encoded by this gene inhibits hemopoiesis and stimulates chemotaxis. This protein is chemotactic in vitro for thymocytes and activated T cells, but not for B cells, macrophages, or neutrophils. The cytokine encoded by this gene may also play a role in mediating homing of lymphocytes to secondary lymphoid organs. It is a high affinity functional ligand for chemokine receptor 7 that is expressed on T and B lymphocytes and a known receptor for another member of the cytokine family (small inducible cytokine A19). |
| Chromosome | 9 |
| Location | 9p13 |
| Start | 34709005 |
| End | 34710167 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 1163 |
| OMIM ID | 602737 |
| HGNC ID | HGNC:10620 |
| Unigene ID | Hs.57907 |
| Ensembl ID | ENSG00000137077 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_002989.3 |
|---|---|
| Exon | join(1..168,271..391,486..668,741..1163) | mRNA Sequence | Download Select all |
| Length | 913 |
CDS Information
| Location | join(102..168,271..391,486..668,741..774) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS6571.1 |
Protein Information
| Protein ID | NP_002980.1 |
|---|---|
| Protein Name | chemokine (C-C motif) ligand 21 |
| Molecular Wt. (Da) | 12251 |
| Protein Sequence | Download Select all |
| Length | 134 |
| Uniprot ID | P61604 |
| Ensembl Protein ID | ENSP00000233893 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| L | Proteolytic Cleavage | 81 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1236 | CCR7 | 2588 | NP_001829.1 | in vivo | 95 070 249 585 422 |
| 1462 | VCAN | 340 | NP_004376.2 | in vitro | 11083865 |
| 51554 | CCRL1 | 7298 | NP_848540.1 | in vitro | 10706668 |
| 56893 | UBQLN4 | 5670 | NP_064516.2 | yeast 2-hybrid | 16713569 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Chemokine signaling pathway | hsa04062 |
| Cytokine-cytokine receptor interaction | hsa04060 |
| NF-kappa B signaling pathway | hsa04064 |
Structure Information
| PDB ID | 2L4N |
|---|---|
| Resolution | |
| Method | SOLUTION NMR |
| Chains | A |
| Molecule | C-C motif chemokine 21 |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| cd01119 | 29-91 | Chemokine_CC_DCCL |
| cl00134 | 29-91 | Chemokine superfamily |
| pfam00048 | 30-90 | IL8 |
| cd00272 | 31-91 | Chemokine_CC |
| cd00169 | 31-91 | Chemokine |
| smart00199 | 30-90 | SCY |
| cd00274 | 39-92 | Chemokine_CX3C |
| cd00271 | 23-98 | Chemokine_C |
Ontology Information
| HPRD ID | 8980 |
|---|---|
| Molecular Class | Chemokine |
| Molecular Function | Transcription regulator activity (GO:0030528) |
| Biological Process | Regulation of immune response (GO:0050776); Regulation of gene expression, epigenetic (GO:0040029); Regulation of cell proliferation (GO:0042127) |
Drug Information
No matching records could be found.