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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| CCL23 | 6368 | chemokine (C-C motif) ligand 23 | 17 | Ckb-8, MPIF-1, MIP-3, CKb8 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 24366523 | 2014 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 6 Stage : - | Biotin label-based antibody array | Up-regulation | - | MPIF-1/CCL23, FGF R5, MIP2, SAA and IL-18 R? were strongly upregulated in rectal cancer when compared to the levels in non-rectal cancer. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Chemokine ligands, "Endogenous ligands" |
| Description | This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, displays chemotactic activity on resting T lymphocytes and monocytes, lower activity on neutrophils and no activity on activated T lymphocytes. The protein is also a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line. In addition, the product of this gene is a potent agonist of the chemokine (C-C motif) receptor 1. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Jul 2013] |
| Chromosome | 17 |
| Location | 17q11.2 |
| Start | 34340096 |
| End | 34345005 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 4910 |
| OMIM ID | 602494 |
| HGNC ID | HGNC:10622 |
| Unigene ID | Hs.169191 |
| Ensembl ID | ENSG00000167236 |
| PharmGKB ID | PA35554 |
mRNA Information
| mRNA ID | ?NM_005064.5 |
|---|---|
| Exon | join(8..154,3583..3642,4118..4232,4668..4920) | mRNA Sequence | Download Select all |
| Length | 604 |
Protein Information
| Protein ID | NP_005055.3 |
|---|---|
| Protein Name | chemokine (C-C motif) ligand 23 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 120 |
| Uniprot ID | O95832 |
| Ensembl Protein ID | ENSP00000295522 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
No STRING Network could be found.
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1230 | CCR1 | 3101 | NP_001286.1 | in vivo | 9 558 365 106 601 250 000 000 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Chemokine signaling pathway | hsa04062 |
| Cytokine-cytokine receptor interaction | hsa04060 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00272 | 54-110 | Chemokine_CC |
| cl00134 | 54-110 | Chemokine superfamily |
| smart00199 | 51-109 | SCY |
| pfam00048 | 48-109 | IL8 |
| cd00169 | 54-110 | Chemokine |
| cd01119 | 52-109 | Chemokine_CC_DCCL |
| cd00271 | 55-120 | Chemokine_C |
| cd00274 | 55-118 | Chemokine_CX3C |
Ontology Information
| HPRD ID | 19076 |
|---|---|
| Molecular Class | Chemokine |
| Molecular Function | Transcription factor activity (GO:0003700) |
| Biological Process | Transcription (GO:0006350) |
Drug Information
No matching records could be found.