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General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23747112 | 2013 | Cell line : - Source : Korean Cell Line Bank (Seoul National University, Seoul, Korea), Yonsei University College of Medicine Cancer Center, Innovative Research (Novi, MI), Sample Type : - No. of Sample : - Stage : - | CpG DNA Microarray, Bisulfite Pyrosequencing, Methylation specific PCR | Methylation | - | sensitivity at stage I was 92.3%, indicating the potential of SDC2 methylation as a blood-based DNA test for early detection of CRC. In clinical validation in tissues from 139 CRC patients, a much higher level of aberrant SDC2 methylation was measured in most primary tumors (97.8%), compared with corresponding nontumor tissue of CRC patients. Sample size: Fresh-frozen primary tumors (n = 139) and paired, adjacent nontumor tissues (n = 139) CRC patients. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Proteoglycans / Cell Surface : Syndecans, "CD molecules" |
| Description | The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-2 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-2 expression has been detected in several different tumor types. |
| Chromosome | 8 |
| Location | 8q22-q23 |
| Start | 96493351 |
| End | 96611809 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 118459 |
| OMIM ID | 142460 |
| HGNC ID | HGNC:10659 |
| Unigene ID | Hs.598247 |
| Ensembl ID | ENSG00000169439 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | XM_005251020.2 |
|---|---|
| Exon | join(1..693,100130..100241,109045..109178,114985..115120, 116035..118422) | mRNA Sequence | Download Select all |
| Length | 3485 |
CDS Information
| Location | join(922..981,100130..100241,109045..109178, 114985..115120,116035..116198) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS6272.1 |
Protein Information
| Protein ID | NP_002989.2 |
|---|---|
| Protein Name | syndecan 2 |
| Molecular Wt. (Da) | 20205 |
| Protein Sequence | Download Select all |
| Length | 201 |
| Uniprot ID | Q02556 |
| Ensembl Protein ID | ENSP00000268638 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 187 |
| S | Phosphorylation | 188 |
| S | Phosphorylation | 187 |
| S | Phosphorylation | 188 |
| S | Phosphorylation | 187 |
| S | Phosphorylation | 188 |
| Y | Phosphorylation | 191 |
| Y | Phosphorylation | 200 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 462 | SERPINC1 | 122 | NP_000479.1 | in vivo | 1315572 |
| 1437 | CSF2 | 734 | NP_000749.2 | in vivo | 10734053 |
| 2335 | FN1 | 626 | NP_997647.1 | in vitro;in vivo | 10772816 |
| 3082 | HGF | 799 | NP_000592.3 | in vitro | 8157651 |
| 7040 | TGFB1 | 1821 | NP_000651.3 | in vitro | 14976204 |
| 7049 | TGFBR3 | 2846 | NP_003234.2 | in vivo | 14976204 |
| 7430 | EZR | 475 | NP_003370.2 | in vitro;in vivo | 10704377 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Cell adhesion molecules (CAMs) | hsa04514 |
| Malaria | hsa05144 |
| Proteoglycans in cancer | hsa05205 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam01034 | 136-199 | Syndecan |
| cl20212 | 136-199 | Syndecan superfamily |
| smart00294 | 169-185 | 4.1m |
| cl02555 | 169-185 | 4.1m superfamily |
Ontology Information
| HPRD ID | 2608 |
|---|---|
| Molecular Class | Adhesion molecule |
| Molecular Function | Transcription regulator activity (GO:0030528) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P34741 | DB00020 | Sargramostim | BiotechDrug |