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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
SEMA3F 6405 sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F  3SEMAK, Sema4 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
25866254   2015Cell line : -

Source : Cancer Genome Atlas.

Sample Type : Data study

No. of Sample : CRC specimens from 85 patients and 229 CRC samples.

Stage : -

-Down-regulation-SEMA3F functions as a suppressor of CRC metastasis via down-regulating the ASCL2-CXCR4 axis.


Gene Details



NC_000003.11 (50192562..50226508)

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Gene Type protein coding
Gene Family Semaphorins, "Immunoglobulin superfamily / Immunoglobulin-like domain containing"
Description This gene encodes a member of the semaphorin III family of secreted signaling proteins that are involved in axon guidance during neuronal development. The encoded protein contains an N-terminal Sema domain, an immunoglobulin loop and a C-terminal basic domain. This gene is expressed by the endothelial cells where it was found to act in an autocrine fashion to induce apoptosis, inhibit cell proliferation and survival, and function as an anti-tumorigenic agent. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]  
Chromosome 3
Location 3p21.3
Start 50192562  
End 50226508  
Strand +  
Gene Sequence

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Length 33947  
OMIM ID 601124   
HGNC ID HGNC:10728   
Unigene ID Hs.32981   
Ensembl ID ENSG00000001617   
PharmGKB ID PA35650   

mRNA Information


mRNA ID ?NM_004186.3
Exon join(1..85,4513..4672,18731..18891,18990..19052, 19169..19288,20034..20126,21706..21799,27222..27341, 27582..27721,27842..27956,28124..28193,28358..28502, 29530..29752,30381..30469,30604..30645,30827..30984, 31219..31286,31551..31684,32643..34013)  
mRNA Sequence

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Length 3451  



CDS Information


   
Location 134..2491
CDS Sequence

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CCDS ID CCDS2811.1



Protein Information


      
Protein IDNP_004177.3
Protein Namesema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
Molecular Wt. (Da)72132
Protein Sequence

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Length 785  
Uniprot IDQ13330
Ensembl Protein ID ENSP00000333633  



Post-translational Modification Information (Source : HPRD)


No matching records could be found.

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                            
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
6462SHBG1646NP_001031.2yeast 2-hybrid15862967   
7317UBA12440NP_003325.2yeast 2-hybrid16169070   
7422VEGFA1889NP_001020537.2in vitro;in vivo12845630   
80723TMEM2215532NP_079522.2yeast 2-hybrid16169070   


Pathway Information


      
Pathway Name Pathway ID
Axon guidance hsa04360


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd1125448-548  Sema_3F
cl1569348-548  Sema superfamily
cd05871609-697  Ig_Semaphorin_classIII
cl11960609-697  Ig superfamily
cd1123948-548  Sema_3
cd1125153-548  Sema_3C
cd1124930-548  Sema_3A
cd1125057-548  Sema_3B
pfam0140357-529  Sema
cd1125256-548  Sema_3D
cd1125548-548  Sema_3G
cd1125356-548  Sema_3E
cd1123555-546  Sema_semaphorin
smart0063057-521  Sema
cd1124055-545  Sema_4
cd1126250-545  Sema_4G
cd1123753-548  Sema_1A
cd1125956-540  Sema_4D
cd1126056-545  Sema_4E
cd1124267-497  Sema_6
cd1125856-545  Sema_4C
cd1125653-545  Sema_4A
cd1125755-545  Sema_4B
cd1126956-494  Sema_6D
cd1123857-545  Sema_2A
cd1124153-545  Sema_5
cd1126669-495  Sema_6A
cd1126769-500  Sema_6B
cd1126154-543  Sema_4F
cd1127056-494  Sema_6E
cd1126456-494  Sema_5B
cd1126553-543  Sema_5C
cd1126353-534  Sema_5A
cd1126869-494  Sema_6C
cd1124357-545  Sema_7A
cd0929556-541  Sema
cd04979609-697  Ig_Semaphorin_C
cd11272478-588  Sema_plexin_A2
cd11236276-498  Sema_plexin_like
smart00423547-584  PSI
cl02601547-584  PSI superfamily
cd11245267-501  Sema_plexin_B
cd11276272-493  Sema_plexin_B2
cd00096622-681  Ig
cd11275276-500  Sema_plexin_B1
cd05873619-697  Ig_Sema4D_like
pfam01437547-575  PSI
cd04978619-697  Ig4_L1-NrCAM_like
cd05872624-697  Ig_Sema4B_like
smart00410612-696  IG_like
smart00409612-696  IG
smart00408619-681  IGc2
pfam07679619-696  I-set


Ontology Information


   
HPRD ID2161
Molecular ClassLigand
Molecular FunctionOxidoreductase activity (GO:0016491)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO