Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| SFPQ | 6421 | splicing factor proline/glutamine-rich | 1 | PSF, PPP1R140 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 21864731 | 2011 | Cell line : SW480-ADH Source : - Sample Type : - No. of Sample : - Stage : - | Immunofluorescence, confocal microscopy,2D-DIGE electrophoresis,LCMS,Western blotting, real time RT-PCR | Down-regulation | 0.75 | - |
| 25025966 | 2014 | Cell line : LoVo,HCT116 Source : - Sample Type : - No. of Sample : - Stage : TNM Stage IV | real time RT-PCR,RNA-binding protein immunoprecipitation,Immunofluorescence staining and confocal microscopy,Soft agar colony formation assay,Fluorescence in situ hybridisation,Immunohistochemistry | Unknown | - | MALAT1 and SFPQ could be a novel therapeutic target for CRC. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | RNA binding motif (RRM) containing |
| Description | - |
| Chromosome | 1 |
| Location | 1p34.3 |
| Start | 35641981 |
| End | 35658766 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 16786 |
| OMIM ID | 605199 |
| HGNC ID | HGNC:10774 |
| Unigene ID | Hs.355934 |
| Ensembl ID | ENSG00000116560 |
| PharmGKB ID | PA35690 |
mRNA Information
| mRNA ID | ?NM_005066.2 |
|---|---|
| Exon | join(1..937,1630..1818,2164..2465,2566..2661,3777..3973, 4072..4156,5069..5186,5908..5956,6037..6158,15123..15170, 15760..15840,16688..16779) | mRNA Sequence | Download Select all |
| Length | 2316 |
Protein Information
| Protein ID | NP_005057.1 |
|---|---|
| Protein Name | splicing factor proline/glutamine-rich |
| Molecular Wt. (Da) | 37831 |
| Protein Sequence | Download Select all |
| Length | 707 |
| Uniprot ID | O95835 |
| Ensembl Protein ID | ENSP00000253339 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| R | Methylation | 9 |
| R | Methylation | 7 |
| R | Methylation | 19 |
| R | Methylation | 25 |
| S | Phosphorylation | 33;- |
| S | Phosphorylation | 225 |
| S | Phosphorylation | 273 |
| S | Phosphorylation | 283 |
| T | Phosphorylation | 687 |
| K | Acetylation | 338 |
| K | Acetylation | 421 |
| K | Acetylation | 319 |
| K | Acetylation | 472 |
| K | Acetylation | 330 |
| T | Phosphorylation | 226 |
| Y | Phosphorylation | 320 |
| S | Phosphorylation | 626 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 2274 | FHL2 | 4026 | NP_001441.4 | yeast 2-hybrid | 11161712 |
| 2521 | FUS | 660 | NP_004951.1 | in vivo | 15975576 |
| 4841 | NONO | 2098 | NP_031389.3 | in vitro;in vivo;yeast 2-hybrid | 12403470 |
| 5725 | PTBP1 | 2823 | NP_002810.1 | in vitro;in vivo | 10 653 975 844 940 100 000 000 |
| 6626 | SNRPA | 1658 | NP_004587.1 | in vitro;in vivo | 9848648 |
| 7150 | TOP1 | 535 | NP_003277.1 | in vivo | 9756848 |
| 25942 | SIN3A | 9690 | NP_056292.1 | in vitro;in vivo | 11259580 |
| 51155 | HN1 | 13665 | NP_001002032.1 | yeast 2-hybrid | 16169070 |
| 55269 | PSPC1 | 10172 | AAL59601.1 | in vivo | 15140795 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd12948 | 442-538 | NOPS_PSF |
| cl06904 | 442-538 | eNOPS_SF superfamily |
| cd12333 | 372-451 | RRM2_p54nrb_like |
| cl17169 | 372-451 | RRM_SF superfamily |
| cd12587 | 296-366 | RRM1_PSF |
| cl17169 | 296-366 | RRM_SF superfamily |
| cd12946 | 442-534 | NOPS_p54nrb_PSF_PSPC1 |
| cd12589 | 372-451 | RRM2_PSP1 |
| cd12949 | 442-535 | NOPS_PSPC1 |
| cd12590 | 372-451 | RRM2_PSF |
| cd12591 | 372-451 | RRM2_p54nrb |
| cd12947 | 442-535 | NOPS_p54nrb |
| cd12931 | 442-531 | eNOPS_SF |
| cd12332 | 296-366 | RRM1_p54nrb_like |
| cd12945 | 442-539 | NOPS_NONA_like |
| cd12588 | 296-366 | RRM1_p54nrb |
| cd12586 | 296-366 | RRM1_PSP1 |
| pfam08075 | 444-495 | NOPS |
| cd00590 | 299-365 | RRM_SF |
| pfam00076 | 373-436 | RRM_1 |
| cd00590 | 373-436 | RRM_SF |
| pfam00076 | 299-363 | RRM_1 |
| cd12414 | 298-367 | RRM2_RBM28_like |
| cd12382 | 299-368 | RRM_RBMX_like |
| cd12354 | 297-365 | RRM3_TIA1_like |
| cd12399 | 298-367 | RRM_HP0827_like |
| cd12316 | 298-364 | RRM3_RBM19_RRM2_MRD1 |
| cd12346 | 299-363 | RRM3_NGR1_NAM8_like |
| cd12395 | 300-364 | RRM2_RBM34 |
| cd12389 | 299-368 | RRM2_RAVER |
| cd12413 | 299-369 | RRM1_RBM28_like |
| cd12566 | 298-364 | RRM2_MRD1 |
| cd12398 | 300-367 | RRM_CSTF2_RNA15_like |
| cd12311 | 299-364 | RRM_SRSF2_SRSF8 |
| cd12384 | 375-429 | RRM_RBM24_RBM38_like |
| cd12449 | 298-364 | RRM_CIRBP_RBM3 |
| cd12380 | 299-364 | RRM3_I_PABPs |
| cd12310 | 299-367 | RRM3_Spen |
| cd12223 | 299-367 | RRM_SR140 |
| cd12415 | 375-429 | RRM3_RBM28_like |
| cd12407 | 298-368 | RRM_FOX1_like |
| cd12373 | 298-368 | RRM_SRSF3_like |
| cd12229 | 299-357 | RRM_G3BP |
| cd12412 | 298-367 | RRM_DAZL_BOULE |
| cd12413 | 375-429 | RRM1_RBM28_like |
| cd12384 | 297-367 | RRM_RBM24_RBM38_like |
| cd12381 | 373-427 | RRM4_I_PABPs |
| cd12390 | 296-366 | RRM3_RAVER |
| cd12322 | 297-368 | RRM2_TDP43 |
| cd12343 | 298-364 | RRM1_2_CoAA_like |
| cd12567 | 298-364 | RRM3_RBM19 |
| cd12361 | 298-365 | RRM1_2_CELF1-6_like |
| cd12226 | 298-367 | RRM_NOL8 |
| cd12380 | 375-429 | RRM3_I_PABPs |
| cd12363 | 372-431 | RRM_TRA2 |
| cd12448 | 299-364 | RRM2_gar2 |
| cd12454 | 299-366 | RRM2_RIM4_like |
| cd12674 | 373-427 | RRM1_Nop4p |
| cd12680 | 373-427 | RRM_THOC4 |
| cd12564 | 298-367 | RRM1_RBM19 |
| cd12355 | 298-367 | RRM_RBM18 |
| cd12524 | 299-367 | RRM1_MEI2_like |
| cd12450 | 298-368 | RRM1_NUCLs |
| cd12622 | 300-363 | RRM3_PUB1 |
| cd12449 | 371-430 | RRM_CIRBP_RBM3 |
| cd12450 | 373-429 | RRM1_NUCLs |
| cd12606 | 298-364 | RRM1_RBM4 |
| cd12377 | 299-366 | RRM3_Hu |
| cd12251 | 372-430 | RRM3_hnRNPR_like |
| cd12363 | 299-367 | RRM_TRA2 |
| cd12341 | 297-362 | RRM_hnRNPC_like |
| cd12447 | 373-429 | RRM1_gar2 |
| cd12312 | 299-367 | RRM_SRSF10_SRSF12 |
| cd12251 | 299-367 | RRM3_hnRNPR_like |
| cd12309 | 299-363 | RRM2_Spen |
| cd12671 | 299-367 | RRM_CSTF2_CSTF2T |
| cd12389 | 373-427 | RRM2_RAVER |
| cd12418 | 297-366 | RRM_Aly_REF_like |
| cd12399 | 373-429 | RRM_HP0827_like |
| pfam13893 | 313-367 | RRM_5 |
| cd12250 | 297-349 | RRM2_hnRNPR_like |
| cd12330 | 298-346 | RRM2_Hrp1p |
| cd12674 | 299-368 | RRM1_Nop4p |
| cd12371 | 298-364 | RRM2_PUF60 |
| cd12315 | 298-367 | RRM1_RBM19_MRD1 |
| cd12353 | 299-363 | RRM2_TIA1_like |
| cd12375 | 299-367 | RRM1_Hu_like |
| cd12651 | 299-367 | RRM2_SXL |
| cd12415 | 299-367 | RRM3_RBM28_like |
| cd12618 | 299-368 | RRM2_TIA1 |
| cd12353 | 375-427 | RRM2_TIA1_like |
| cd12387 | 375-429 | RRM3_hnRNPM_like |
| cd12617 | 299-368 | RRM2_TIAR |
| cd12247 | 299-355 | RRM2_U1A_like |
| cd12619 | 375-427 | RRM2_PUB1 |
| cd12447 | 298-367 | RRM1_gar2 |
| cd12338 | 298-366 | RRM1_SRSF1_like |
| cd12281 | 297-368 | RRM1_TatSF1_like |
| cd12335 | 371-448 | RRM2_SF3B4 |
| cd12609 | 298-364 | RRM2_CoAA |
| cd12327 | 298-341 | RRM2_DAZAP1 |
| cd12272 | 298-364 | RRM2_PHIP1 |
| cd12418 | 373-430 | RRM_Aly_REF_like |
| cd12411 | 292-364 | RRM_ist3_like |
| cd12414 | 373-429 | RRM2_RBM28_like |
| cd12635 | 298-367 | RRM2_CELF3_4_5_6 |
| cd12224 | 299-365 | RRM_RBM22 |
| cd12392 | 298-364 | RRM2_SART3 |
| cd12394 | 299-364 | RRM1_RBM34 |
| cd12410 | 298-368 | RRM2_RRT5 |
| cd12316 | 373-436 | RRM3_RBM19_RRM2_MRD1 |
| cd12552 | 299-366 | RRM_Nop15p |
| cd12404 | 299-366 | RRM2_NCL |
| cd12608 | 298-364 | RRM1_CoAA |
| cd12337 | 298-367 | RRM1_SRSF4_like |
| cd12306 | 300-364 | RRM_II_PABPs |
| cd12367 | 383-449 | RRM2_RBM45 |
| cd12254 | 373-431 | RRM_hnRNPH_ESRPs_RBM12_like |
| cd12637 | 298-367 | RRM2_FCA |
| cd12235 | 373-428 | RRM_PPIL4 |
| cd12408 | 301-353 | RRM_eIF3G_like |
| cd12633 | 298-367 | RRM1_FCA |
| cd12393 | 296-367 | RRM_ZCRB1 |
| cd12284 | 299-364 | RRM2_RBM23_RBM39 |
| cd12597 | 298-366 | RRM1_SRSF1 |
| cd12323 | 298-346 | RRM2_MSI |
| cd12599 | 298-364 | RRM1_SF2_plant_like |
| cd12242 | 375-427 | RRM_SLIRP |
| cd12579 | 373-427 | RRM2_hnRNPA0 |
| cd12284 | 373-429 | RRM2_RBM23_RBM39 |
| cd12330 | 375-428 | RRM2_Hrp1p |
| cd12417 | 299-364 | RRM_SAFB_like |
| cd12565 | 298-367 | RRM1_MRD1 |
| cd12347 | 299-364 | RRM_PPIE |
| cd12463 | 298-360 | RRM_G3BP1 |
| cd12340 | 298-364 | RBD_RRM1_NPL3 |
| cd12227 | 299-368 | RRM_SCAF4_SCAF8 |
| cd12370 | 297-364 | RRM1_PUF60 |
| cd12358 | 299-348 | RRM1_VICKZ |
| cd12336 | 296-365 | RRM_RBM7_like |
| cd12388 | 298-367 | RRM1_RAVER |
| cd12318 | 297-366 | RRM5_RBM19_like |
| cd12298 | 375-429 | RRM3_Prp24 |
| cd12675 | 298-367 | RRM2_Nop4p |
| cd12321 | 299-368 | RRM1_TDP43 |
| cd12336 | 373-424 | RRM_RBM7_like |
| cd12376 | 299-367 | RRM2_Hu_like |
| cd12400 | 299-364 | RRM_Nop6 |
| cd12395 | 375-429 | RRM2_RBM34 |
| cd12362 | 299-364 | RRM3_CELF1-6 |
| cd12494 | 373-429 | RRM3_hnRNPR |
| cd12230 | 298-365 | RRM1_U2AF65 |
| cd12559 | 299-367 | RRM_SRSF10 |
| cd12429 | 383-450 | RRM_DNAJC17 |
| cd12556 | 299-362 | RRM2_RBM15B |
| cd12329 | 298-341 | RRM2_hnRNPD_like |
| cd12231 | 298-367 | RRM2_U2AF65 |
| cd12276 | 299-365 | RRM2_MEI2_EAR1_like |
| cd12397 | 299-367 | RRM2_Nop13p_fungi |
| cd12234 | 299-367 | RRM1_AtRSp31_like |
| cd12598 | 298-348 | RRM1_SRSF9 |
| cd12665 | 373-427 | RRM2_RAVER1 |
| cd12379 | 375-429 | RRM2_I_PABPs |
| cd12656 | 299-371 | RRM3_HuD |
| cd12331 | 299-366 | RRM_NRD1_SEB1_like |
| cd12593 | 299-365 | RRM_RBM11 |
| cd12555 | 299-366 | RRM2_RBM15 |
| cd12320 | 297-367 | RRM6_RBM19_RRM5_MRD1 |
| cd12298 | 299-364 | RRM3_Prp24 |
| cd12570 | 298-367 | RRM5_MRD1 |
| cd12637 | 373-447 | RRM2_FCA |
| cd12345 | 375-449 | RRM2_SECp43_like |
| cd12305 | 306-369 | RRM_NELFE |
| cd12464 | 293-337 | RRM_G3BP2 |
| cd12344 | 299-368 | RRM1_SECp43_like |
| cd12421 | 299-369 | RRM1_PTBP1_hnRNPL_like |
| cd12265 | 299-367 | RRM_SLT11 |
| cd12448 | 373-429 | RRM2_gar2 |
| cd12523 | 295-356 | RRM2_MRN1 |
| cd12378 | 299-364 | RRM1_I_PABPs |
| cd12391 | 299-360 | RRM1_SART3 |
| cd12365 | 299-365 | RRM_RNPS1 |
| cd12326 | 295-348 | RRM1_hnRNPA0 |
| cd12328 | 373-427 | RRM2_hnRNPA_like |
| cd12652 | 299-367 | RRM2_Hu |
| cd12386 | 375-418 | RRM2_hnRNPM_like |
| cd12239 | 297-367 | RRM2_RBM40_like |
| cd12352 | 373-427 | RRM1_TIA1_like |
| cd12486 | 297-364 | RRM1_ACF |
| cd12661 | 298-370 | RRM3_hnRNPM |
| cd12290 | 299-356 | RRM1_LARP7 |
| cd12484 | 297-358 | RRM1_RBM46 |
| cd12565 | 375-427 | RRM1_MRD1 |
| cd12676 | 373-418 | RRM3_Nop4p |
| cd12271 | 299-365 | RRM1_PHIP1 |
| cd12663 | 298-366 | RRM1_RAVER1 |
| cd12666 | 373-427 | RRM2_RAVER2 |
| cd12412 | 375-427 | RRM_DAZL_BOULE |
| cd12650 | 296-367 | RRM1_Hu |
| cd12307 | 299-365 | RRM_NIFK_like |
| cd12283 | 375-427 | RRM1_RBM39_like |
| cd12350 | 299-330 | RRM3_SHARP |
| cd12408 | 372-430 | RRM_eIF3G_like |
| cd12645 | 297-367 | RRM_SRSF3 |
| cd12267 | 375-430 | RRM_YRA1_MLO3 |
| cd12325 | 299-356 | RRM1_hnRNPA_hnRNPD_like |
| cd12485 | 297-364 | RRM1_RBM47 |
| cd12402 | 300-367 | RRM_eIF4B |
| cd12409 | 298-365 | RRM1_RRT5 |
| cd12551 | 299-364 | RRM_II_PABPN1L |
| cd12391 | 375-430 | RRM1_SART3 |
| cd12245 | 299-333 | RRM_scw1_like |
| cd12342 | 298-362 | RRM_Nab3p |
| cd12392 | 373-427 | RRM2_SART3 |
| cd12294 | 373-447 | RRM_Rrp7A |
| cd12249 | 297-364 | RRM1_hnRNPR_like |
| cd12325 | 378-429 | RRM1_hnRNPA_hnRNPD_like |
| cd12495 | 373-429 | RRM3_hnRNPQ |
| cd12654 | 299-368 | RRM3_HuB |
| cd12681 | 373-430 | RRM_SKAR |
| cd12492 | 297-367 | RRM2_RBM46 |
| cd12378 | 372-429 | RRM1_I_PABPs |
| cd12244 | 299-367 | RRM2_MSSP |
| cd12361 | 373-447 | RRM1_2_CELF1-6_like |
| cd12574 | 298-338 | RRM1_DAZAP1 |
| cd12579 | 298-367 | RRM2_hnRNPA0 |
| pfam03938 | 495-567 | OmpH |
| cl21485 | 495-567 | OmpH superfamily |
| cd12641 | 297-367 | RRM_TRA2B |
| cd12381 | 299-367 | RRM4_I_PABPs |
| cd12497 | 299-367 | RRM3_RBM47 |
| cd12614 | 299-367 | RRM1_PUB1 |
| cd12619 | 299-364 | RRM2_PUB1 |
| cd12607 | 298-365 | RRM2_RBM4 |
| cd12558 | 298-368 | RRM3_RBM15B |
| cd12246 | 299-367 | RRM1_U1A_like |
| cd12236 | 299-364 | RRM_snRNP70 |
| cd12632 | 298-367 | RRM1_CELF3_4_5_6 |
| cd12655 | 299-368 | RRM3_HuC |
| pfam13893 | 391-436 | RRM_5 |
| cd12569 | 375-430 | RRM4_RBM19 |
| cd12383 | 298-337 | RRM_RBM42 |
| cd12296 | 297-334 | RRM1_Prp24 |
| cd12306 | 375-427 | RRM_II_PABPs |
| cd12494 | 299-367 | RRM3_hnRNPR |
| cd12310 | 373-429 | RRM3_Spen |
| cd12369 | 298-365 | RRM4_RBM45 |
| cd12237 | 373-431 | RRM_snRNP35 |
| cd12578 | 378-427 | RRM1_hnRNPA_like |
| cd12240 | 299-364 | RRM_NCBP2 |
| cd12243 | 373-429 | RRM1_MSSP |
| cd12334 | 375-420 | RRM1_SF3B4 |
| cd12636 | 298-367 | RRM2_Bruno_like |
| cd12297 | 297-366 | RRM2_Prp24 |
| cd12618 | 375-430 | RRM2_TIA1 |
| cd12673 | 298-364 | RRM_BOULE |
| cd12241 | 299-322 | RRM_SF3B14 |
| cd12566 | 373-436 | RRM2_MRD1 |
| cd12614 | 373-429 | RRM1_PUB1 |
| cd12617 | 375-427 | RRM2_TIAR |
| cd12422 | 373-427 | RRM2_PTBP1_hnRNPL_like |
| cd12585 | 298-337 | RRM2_hnRPDL |
| cd12360 | 297-368 | RRM_cwf2 |
| cd12366 | 379-429 | RRM1_RBM45 |
| cd12328 | 298-337 | RRM2_hnRNPA_like |
| cd12578 | 298-350 | RRM1_hnRNPA_like |
| cd12775 | 299-371 | RRM2_HuB |
| cd12662 | 298-370 | RRM3_MYEF2 |
| cd12372 | 373-430 | RRM_CFIm68_CFIm59 |
| cd12339 | 298-365 | RRM2_SRSF1_4_like |
| cd12279 | 299-365 | RRM_TUT1 |
| cd12344 | 378-429 | RRM1_SECp43_like |
| cd12382 | 373-427 | RRM_RBMX_like |
| cd12571 | 297-367 | RRM6_RBM19 |
| cd12505 | 401-430 | RRM2_GRSF1 |
| cd12634 | 298-367 | RRM2_CELF1_2 |
| cd12242 | 298-342 | RRM_SLIRP |
| cd12324 | 375-441 | RRM_RBM8 |
| cd12365 | 373-427 | RRM_RNPS1 |
| cd12407 | 387-430 | RRM_FOX1_like |
| cd12317 | 299-348 | RRM4_RBM19_RRM3_MRD1 |
| cd12444 | 297-321 | RRM1_CPEBs |
| smart00360 | 298-364 | RRM |
| TIGR01628 | 299-427 | PABP-1234 |
| TIGR01628 | 299-429 | PABP-1234 |
| smart00360 | 375-429 | RRM |
| COG0724 | 267-480 | RRM |
| pfam14259 | 299-363 | RRM_6 |
| TIGR01628 | 299-430 | PABP-1234 |
| pfam14259 | 373-436 | RRM_6 |
| TIGR01661 | 296-427 | ELAV_HUD_SF |
| PRK12704 | 461-594 | PRK12704 |
| TIGR01645 | 297-427 | half-pint |
| TIGR01648 | 297-445 | hnRNP-R-Q |
| TIGR01648 | 297-434 | hnRNP-R-Q |
| PLN03134 | 298-368 | PLN03134 |
| TIGR01642 | 298-371 | U2AF_lg |
| TIGR01659 | 287-427 | sex-lethal |
| TIGR01661 | 299-372 | ELAV_HUD_SF |
| TIGR01649 | 301-427 | hnRNP-L_PTB |
| TIGR01622 | 298-380 | SF-CC1 |
| PTZ00121 | 424-595 | PTZ00121 |
| TIGR01661 | 299-380 | ELAV_HUD_SF |
| TIGR01622 | 267-429 | SF-CC1 |
| PTZ00121 | 499-599 | PTZ00121 |
| PLN03134 | 370-427 | PLN03134 |
| TIGR01659 | 287-367 | sex-lethal |
| pfam12037 | 497-608 | DUF3523 |
Ontology Information
| HPRD ID | 4131 |
|---|---|
| Molecular Class | RNA binding protein |
| Molecular Function | Protein binding (GO:0005515) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.