Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| SFRP1 | 6422 | Secreted frizzled-related protein 1 | 8 | FRP; FRP1; FrzA; FRP-1; SARP2 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22703586 | 2012 | Cell line : - Source : Xinhua Hospital, School of Medicine, Shanghai Jiaotong University. Sample Type : CRC tumor and normal tissue No. of Sample : 40 CRC tissues and matched adjacent normal colorectal mucosa Stage : - | real time RT-PCR, TargetScan and miRanda, microarray analysis | Down-regulation | - | SFRP1 expression level is decreased due to Up-regulation of SFRP2 specific micro RNA mir- 21 and mir 29a. |
| 22736139 | 2012 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 90 patients with colorectal cancer, 60 patients with adenomatous polyp, and 20 healthy controls. Stage : - | Methylation specific PCR | Methylation | - | DNA methylation levels of vimentin, sFRP1 and HPP1 are significantly higher in colorectal cancer tissue and and may be used as early diagnosis method for colorectal cancer.
|
| 23010642 | 2012 | Cell line : - Source : Saudi Arabian patients Sample Type : - No. of Sample : - Stage : - | K-means clustering analysis of the methylation events. | Methylation | - | SFRP1 showing high frequency of methylation.
|
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Secreted frizzled-related proteins |
| Description | This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. Members of this family act as soluble modulators of Wnt signaling; epigenetic silencing of SFRP genes leads to deregulated activation of the Wnt-pathway which is associated with cancer. This gene may also be involved in determining the polarity of photoreceptor cells in the retina. [provided by RefSeq, Sep 2009] |
| Chromosome | 8 |
| Location | 8p11.21 |
| Start | 41261957 |
| End | 41309471 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 47515 |
| OMIM ID | 604156 |
| HGNC ID | HGNC:10776 |
| Unigene ID | Hs.213424 |
| Ensembl ID | ENSG00000104332 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_003012.4 |
|---|---|
| Exon | join(1..856,5934..6011,43983..47515) | mRNA Sequence | Download Select all |
| Length | 4482 |
CDS Information
| Location | join(313..856,5934..6011,43983..44305) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS34886.1 |
Protein Information
| Protein ID | NP_003003.3 |
|---|---|
| Protein Name | Secreted frizzled-related protein 1 |
| Molecular Wt. (Da) | 32538 |
| Protein Sequence | Download Select all |
| Length | 314 |
| Uniprot ID | Q16678 |
| Ensembl Protein ID | ENSP00000478561 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 7471 | WNT1 | 1276 | NP_005421.1 | in vitro;in vivo | 10347172 |
| 7472 | WNT2 | 999 | NP_003382.1 | in vitro;in vivo | 10347172 |
| 8323 | FZD6 | 4559 | NP_003497.2 | in vitro;in vivo | 10347172 |
| 54361 | WNT4 | 4601 | NP_110388.2 | in vivo | 11287180 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Wnt signaling pathway | hsa04310 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd07443 | 52-175 | CRD_SFRP1 |
| cl02447 | 52-175 | CRD_FZ superfamily |
| cd03580 | 183-306 | NTR_Sfrp1_like |
| cl02512 | 183-306 | NTR_like superfamily |
| cd07444 | 52-169 | CRD_SFRP5 |
| cd07453 | 58-192 | CRD_crescent |
| cd07446 | 54-180 | CRD_SFRP2 |
| smart00063 | 61-169 | FRI |
| pfam01392 | 58-167 | Fz |
| cd07452 | 57-189 | CRD_sizzled |
| cd07066 | 57-171 | CRD_FZ |
| cd07448 | 62-177 | CRD_FZ4 |
| cd07458 | 62-168 | CRD_FZ1_like |
| cd07457 | 62-173 | CRD_FZ9_like |
| cd07456 | 67-163 | CRD_FZ5_like |
| cd07463 | 55-184 | CRD_FZ9 |
| cd07462 | 57-161 | CRD_FZ10 |
| cd07465 | 62-180 | CRD_FZ1 |
| cd07466 | 62-168 | CRD_FZ7 |
| cd07460 | 54-178 | CRD_FZ5 |
| cd07461 | 54-162 | CRD_FZ8 |
| cd07464 | 62-161 | CRD_FZ2 |
| cd07449 | 62-164 | CRD_FZ3 |
| cd07442 | 55-171 | CRD_SFRP4 |
| cd07441 | 62-171 | CRD_SFRP3 |
| cd07454 | 61-167 | CRD_LIN_17 |
| cd07455 | 55-172 | CRD_Collagen_XVIII |
| cd07888 | 62-162 | CRD_corin_2 |
| cd03523 | 200-304 | NTR_like |
| cd07450 | 62-180 | CRD_FZ6 |
| cd07447 | 56-160 | CRD_Carboxypeptidase_Z |
| pfam01759 | 200-299 | NTR |
| cd07445 | 104-160 | CRD_corin_1 |
| cd07451 | 83-159 | CRD_SMO |
| smart00643 | 199-299 | C345C |
Ontology Information
| HPRD ID | 5617 |
|---|---|
| Molecular Class | Secreted polypeptide |
| Molecular Function | Oxidoreductase activity (GO:0016491) |
| Biological Process | Metabolism (GO:0008152); Energy pathways (GO:0006091) |
Drug Information
No matching records could be found.