Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| SFRS1 | 6426 | Splicing factor, arginine/serine-rich 1 (splicing factor 2, alternate splicing factor) | 17 | ASF; SF2; SFRS1; SF2p33; Srp30a |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 20089989 | 2010 | Cell line : - Source : VU University Medical Center, Amsterdam, The Netherlands. Sample Type : CRC tumor and normal tissue No. of Sample : - Stage : - | Biochemical isolation to nano-LC-MS/MS analysis | Unknown | - | - |
| 24550521 | 2014 | Cell line : HT29 Source : - Sample Type : - No. of Sample : - Stage : - | SDS-PAGE and Western blotting,Cell fractionation,Confocal immunofluorescence microscopy | Up-regulation | - | SRSF1 as a prime regulator of Rac1b expression in colorectal cells and provide further mechanistic insight into how the regulation of alternative splicing events by protein kinases can contribute to sustain tumor cell survival. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Serine/arginine-rich splicing factors, RNA binding motif (RRM) containing |
| Description | This gene encodes a member of the arginine/serine-rich splicing factor protein family, and functions in both constitutive and alternative pre-mRNA splicing. The protein binds to pre-mRNA transcripts and components of the spliceosome, and can either activate or repress splicing depending on the location of the pre-mRNA binding site. The protein's ability to activate splicing is regulated by phosphorylation and interactions with other splicing factor associated proteins. Multiple transcript variants encoding different isoforms have been found for this gene. In addition, a pseudogene of this gene has been found on chromosome 13. [provided by RefSeq, Sep 2010] |
| Chromosome | 17 |
| Location | 17q22 |
| Start | 58000919 |
| End | 58007346 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 6428 |
| OMIM ID | 600812 |
| HGNC ID | HGNC:10780 |
| Unigene ID | Hs.68714 |
| Ensembl ID | ENSG00000136450 |
| PharmGKB ID | PA35696 |
mRNA Information
| mRNA ID | NM_006924.4 |
|---|---|
| Exon | join(1..403,820..1004,1374..1546,1747..6428) | mRNA Sequence | Download Select all |
| Length | 5468 |
CDS Information
| Location | join(210..403,820..1004,1374..1546,2306..2344) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | - |
Protein Information
| Protein ID | NP_001071634.1 |
|---|---|
| Protein Name | Splicing factor, arginine/serine-rich 1 (splicing factor 2, alternate splicing factor) |
| Molecular Wt. (Da) | 22329 |
| Protein Sequence | Download Select all |
| Length | 201 |
| Uniprot ID | P05181 |
| Ensembl Protein ID | ENSP00000252945 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| R | Methylation | 97 |
| R | Methylation | 93 |
| R | Methylation | 109 |
| Y | Phosphorylation | 189;- |
| S | Phosphorylation | 199;- |
| S | Phosphorylation | 201;- |
| Y | Phosphorylation | 202;- |
| S | Phosphorylation | 225;- |
| Y | Phosphorylation | 226;- |
| Y | Phosphorylation | 237;- |
| S | Phosphorylation | 231;- |
| S | Phosphorylation | 227;- |
| S | Phosphorylation | 238;- |
| S | Phosphorylation | 234;- |
| S | Phosphorylation | 205;- |
| S | Phosphorylation | 2;- |
| S | Phosphorylation | 2;- |
| S | Acetylation | 2 |
| S | Acetylation | 2 |
| K | Acetylation | 38 |
| K | Acetylation | 38 |
| K | Acetylation | 179 |
| K | Acetylation | 179 |
| S | Phosphorylation | 242 |
| S | Phosphorylation | 244 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 925 | CD8A | 1737 | NP_001759.3 | in vitro | 10022843 |
| 4800 | NFYA | 1793 | NP_002496.1 | in vitro;in vivo | 15243141 |
| 6625 | SNRNP70 | 1617 | NP_003080.2 | in vitro | 9799243 |
| 7150 | TOP1 | 535 | NP_003277.1 | in vitro;in vivo | 9 611 241 122 707 050 000 000 |
| 7307 | U2AF1 | 1871 | NP_006749.1 | in vitro;in vivo | 97 992 438 261 509 |
| 8233 | ZRSR2 | 2068 | NP_005080.1 | in vitro;yeast 2-hybrid | 9237760 |
| 84708 | LNX1 | 17287 | NP_001119800.1 | yeast 2-hybrid | 16189514 |
| 85362 | C20orf158 | 12752 | NP_689515.1 | yeast 2-hybrid | 16189514 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Herpes simplex infection | hsa05168 |
| Spliceosome | hsa03040 |
Structure Information
| PDB ID | 1X4A |
|---|---|
| Resolution | - |
| Method | SOLUTION NMR |
| Chains | A |
| Molecule | splicing factor, arginine/serine-rich 1 (splicing factor 2, alternate splicing factor) variant |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| cd12601 | 121-193 | RRM2_SRSF1_like |
| cl17169 | 121-193 | RRM_SF superfamily |
| cd12597 | 17-90 | RRM1_SRSF1 |
| cl17169 | 17-90 | RRM_SF superfamily |
| cd12767 | 121-196 | RRM2_SRSF1 |
| cd12768 | 122-192 | RRM2_SRSF9 |
| cd12338 | 17-88 | RRM1_SRSF1_like |
| cd12598 | 17-88 | RRM1_SRSF9 |
| cd12599 | 17-87 | RRM1_SF2_plant_like |
| cd12339 | 122-193 | RRM2_SRSF1_4_like |
| cd12602 | 122-193 | RRM2_SF2_plant_like |
| cd12373 | 17-88 | RRM_SRSF3_like |
| cd00590 | 18-87 | RRM_SF |
| pfam00076 | 18-85 | RRM_1 |
| cd12600 | 121-180 | RRM2_SRSF4_like |
| cd12337 | 17-88 | RRM1_SRSF4_like |
| cd12341 | 16-84 | RRM_hnRNPC_like |
| cd12382 | Dec-87 | RRM_RBMX_like |
| cd12595 | 17-87 | RRM1_SRSF5 |
| pfam00076 | 123-184 | RRM_1 |
| cd12343 | 17-87 | RRM1_2_CoAA_like |
| cd12765 | 118-175 | RRM2_SRSF5 |
| cd12764 | 122-179 | RRM2_SRSF4 |
| cd12766 | 122-179 | RRM2_SRSF6 |
| cd12399 | 17-86 | RRM_HP0827_like |
| cd12596 | 17-87 | RRM1_SRSF6 |
| cd12645 | 15-88 | RRM_SRSF3 |
| cd12454 | 18-88 | RRM2_RIM4_like |
| cd12392 | 17-86 | RRM2_SART3 |
| cd12646 | 17-87 | RRM_SRSF7 |
| cd12312 | 18-88 | RRM_SRSF10_SRSF12 |
| cd12347 | 18-86 | RRM_PPIE |
| cd12408 | 17-88 | RRM_eIF3G_like |
| cd12233 | 18-88 | RRM_Srp1p_AtRSp31_like |
| cd12229 | 18-87 | RRM_G3BP |
| cd12594 | 17-87 | RRM1_SRSF4 |
| cd12390 | 18-88 | RRM3_RAVER |
| cd12387 | 123-180 | RRM3_hnRNPM_like |
| cd12234 | 18-88 | RRM1_AtRSp31_like |
| cd12311 | 20-86 | RRM_SRSF2_SRSF8 |
| cd12365 | 18-87 | RRM_RNPS1 |
| cd12332 | 16-88 | RRM1_p54nrb_like |
| cd12359 | 17-89 | RRM2_VICKZ |
| cd12226 | 17-87 | RRM_NOL8 |
| cd12371 | 17-86 | RRM2_PUF60 |
| cd12224 | 16-71 | RRM_RBM22 |
| cd12297 | 16-88 | RRM2_Prp24 |
| cd00590 | 123-193 | RRM_SF |
| cd12449 | 17-87 | RRM_CIRBP_RBM3 |
| cd12398 | 18-89 | RRM_CSTF2_RNA15_like |
| cd12350 | 18-86 | RRM3_SHARP |
| cd12340 | 17-74 | RBD_RRM1_NPL3 |
| cd12370 | 16-86 | RRM1_PUF60 |
| cd12355 | 17-76 | RRM_RBM18 |
| cd12380 | 18-86 | RRM3_I_PABPs |
| cd12276 | 18-87 | RRM2_MEI2_EAR1_like |
| cd12273 | 17-87 | RRM1_NEFsp |
| cd12230 | 17-86 | RRM1_U2AF65 |
| cd12407 | 17-86 | RRM_FOX1_like |
| cd12606 | 17-87 | RRM1_RBM4 |
| cd12241 | 18-86 | RRM_SF3B14 |
| cd12250 | 15-70 | RRM2_hnRNPR_like |
| cd12413 | 18-88 | RRM1_RBM28_like |
| cd12290 | 18-71 | RRM1_LARP7 |
| cd12342 | 17-87 | RRM_Nab3p |
| pfam13893 | 34-88 | RRM_5 |
| cd12385 | 122-175 | RRM1_hnRNPM_like |
| cd12237 | 16-88 | RRM_snRNP35 |
| cd12588 | 17-88 | RRM1_p54nrb |
| cd12566 | 17-84 | RRM2_MRD1 |
| cd12467 | 18-87 | RRM_Srp1p_like |
| cd12387 | 18-86 | RRM3_hnRNPM_like |
| cd12329 | 17-71 | RRM2_hnRNPD_like |
| cd12324 | 18-88 | RRM_RBM8 |
| cd12223 | 18-86 | RRM_SR140 |
| cd12658 | 122-176 | RRM1_MYEF2 |
| cd12587 | 16-88 | RRM1_PSF |
| cd12298 | 18-87 | RRM3_Prp24 |
| cd12309 | 18-63 | RRM2_Spen |
| cd12283 | 18-71 | RRM1_RBM39_like |
| cd12559 | 18-88 | RRM_SRSF10 |
| cd12375 | 20-88 | RRM1_Hu_like |
| cd12245 | 18-89 | RRM_scw1_like |
| cd12348 | 18-70 | RRM1_SHARP |
| cd12657 | 122-176 | RRM1_hnRNPM |
| cd12674 | 18-88 | RRM1_Nop4p |
| cd12411 | 18-87 | RRM_ist3_like |
| cd12586 | 16-88 | RRM1_PSP1 |
| cd12675 | 17-88 | RRM2_Nop4p |
| cd12384 | 16-70 | RRM_RBM24_RBM38_like |
| cd12310 | 18-88 | RRM3_Spen |
| cd12322 | 16-88 | RRM2_TDP43 |
| cd12284 | 18-86 | RRM2_RBM23_RBM39 |
| cd12296 | 16-70 | RRM1_Prp24 |
| cd12529 | 18-87 | RRM2_MEI2_like |
| cd12236 | 18-87 | RRM_snRNP70 |
| cd12608 | 17-87 | RRM1_CoAA |
| cd12315 | 17-88 | RRM1_RBM19_MRD1 |
| cd12570 | 17-88 | RRM5_MRD1 |
| cd12378 | 19-70 | RRM1_I_PABPs |
| cd12552 | 18-86 | RRM_Nop15p |
| cd12354 | 16-86 | RRM3_TIA1_like |
| cd12564 | 17-88 | RRM1_RBM19 |
| cd12280 | 18-88 | RRM_FET |
| cd12565 | 17-88 | RRM1_MRD1 |
| cd12414 | 17-88 | RRM2_RBM28_like |
| cd12240 | 18-88 | RRM_NCBP2 |
| cd12352 | 18-86 | RRM1_TIA1_like |
| cd12641 | 30-88 | RRM_TRA2B |
| cd12362 | 18-87 | RRM3_CELF1-6 |
| cd12463 | 17-87 | RRM_G3BP1 |
| cd12607 | 17-87 | RRM2_RBM4 |
| cd12603 | 15-76 | RRM_hnRNPC |
| cd12401 | 19-87 | RRM_eIF4H |
| cd12235 | 18-88 | RRM_PPIL4 |
| cd12571 | 16-74 | RRM6_RBM19 |
| cd12412 | 17-71 | RRM_DAZL_BOULE |
| cd12534 | 18-87 | RRM_SARFH |
| cd12279 | 18-86 | RRM_TUT1 |
| cd12567 | 17-86 | RRM3_RBM19 |
| cd12671 | 18-88 | RRM_CSTF2_CSTF2T |
| cd12313 | 18-88 | RRM1_RRM2_RBM5_like |
| cd12358 | 18-87 | RRM1_VICKZ |
| cd12251 | 18-86 | RRM3_hnRNPR_like |
| cd12316 | 17-86 | RRM3_RBM19_RRM2_MRD1 |
| cd12353 | 18-85 | RRM2_TIA1_like |
| cd12306 | 18-71 | RRM_II_PABPs |
| cd12450 | 17-87 | RRM1_NUCLs |
| cd12231 | 17-86 | RRM2_U2AF65 |
| cd12447 | 17-88 | RRM1_gar2 |
| cd12249 | 15-77 | RRM1_hnRNPR_like |
| cd12357 | 18-85 | RRM_PPARGC1A_like |
| cd12420 | 18-87 | RRM_RBPMS_like |
| cd12269 | 18-71 | RRM_Vip1_like |
| cd12569 | 18-72 | RRM4_RBM19 |
| cd12418 | 16-88 | RRM_Aly_REF_like |
| cd12527 | 20-87 | RRM2_EAR1_like |
| cd12299 | 22-86 | RRM4_Prp24 |
| cd12533 | 18-86 | RRM_EWS |
| cd12661 | 122-195 | RRM3_hnRNPM |
| cd12400 | 18-87 | RRM_Nop6 |
| cd12376 | 18-76 | RRM2_Hu_like |
| cd12271 | 18-87 | RRM1_PHIP1 |
| cd12247 | 22-78 | RRM2_U1A_like |
| cd12379 | Dec-71 | RRM2_I_PABPs |
| cd12330 | 17-86 | RRM2_Hrp1p |
| cd12617 | 18-88 | RRM2_TIAR |
| cd12227 | 18-71 | RRM_SCAF4_SCAF8 |
| cd12560 | 18-88 | RRM_SRSF12 |
| cd12394 | 18-86 | RRM1_RBM34 |
| cd12607 | 125-181 | RRM2_RBM4 |
| cd12335 | 18-70 | RRM2_SF3B4 |
| cd12320 | 16-74 | RRM6_RBM19_RRM5_MRD1 |
| cd12426 | 18-88 | RRM4_PTBPH3 |
| cd12336 | 15-87 | RRM_RBM7_like |
| cd12307 | 18-87 | RRM_NIFK_like |
| cd12415 | 123-167 | RRM3_RBM28_like |
| cd12303 | 18-88 | RRM_spSet1p_like |
| cd12614 | 18-71 | RRM1_PUB1 |
| cd12618 | 18-88 | RRM2_TIA1 |
| cd12325 | 18-71 | RRM1_hnRNPA_hnRNPD_like |
| cd12585 | 17-63 | RRM2_hnRPDL |
| cd12605 | 15-75 | RRM_RALYL |
| cd12254 | 18-71 | RRM_hnRNPH_ESRPs_RBM12_like |
| cd12439 | 16-86 | RRM_TRMT2A |
| cd12328 | 17-75 | RRM2_hnRNPA_like |
| cd12523 | 16-71 | RRM2_MRN1 |
| cd12773 | 18-81 | RRM2_HuR |
| cd12389 | 18-89 | RRM2_RAVER |
| cd12673 | 17-86 | RRM_BOULE |
| cd12535 | 18-88 | RRM_FUS_TAF15 |
| cd12642 | 30-88 | RRM_TRA2A |
| cd12405 | 20-88 | RRM3_NCL |
| cd12662 | 122-195 | RRM3_MYEF2 |
| cd12278 | 56-80 | RRM_eIF3B |
| cd12464 | 17-63 | RRM_G3BP2 |
| cd12609 | 17-87 | RRM2_CoAA |
| cd12524 | 18-70 | RRM1_MEI2_like |
| cd12281 | 16-46 | RRM1_TatSF1_like |
| cd12757 | 17-68 | RRM1_hnRNPAB |
| cd12391 | 18-75 | RRM1_SART3 |
| cd12486 | 16-84 | RRM1_ACF |
| cd12616 | 18-88 | RRM1_TIAR |
| cd12689 | 18-72 | RRM1_hnRNPL_like |
| cd12253 | 57-88 | RRM_PIN4_like |
| cd12681 | 122-180 | RRM_SKAR |
| cd12448 | 18-87 | RRM2_gar2 |
| cd12363 | 20-88 | RRM_TRA2 |
| cd12776 | 15-76 | RRM2_HuC |
| cd12628 | 17-88 | RRM2_IGF2BP1 |
| cd12640 | Sep-87 | RRM3_Bruno_like |
| cd12422 | 35-88 | RRM2_PTBP1_hnRNPL_like |
| cd12393 | 15-86 | RRM_ZCRB1 |
| cd12615 | 18-88 | RRM1_TIA1 |
| cd12604 | 15-76 | RRM_RALY |
| cd12417 | 18-87 | RRM_SAFB_like |
| cd12225 | 18-86 | RRM1_2_CID8_like |
| cd12622 | 18-85 | RRM3_PUB1 |
| cd12446 | 16-67 | RRM_RBM25 |
| cd12244 | 18-69 | RRM2_MSSP |
| cd12409 | 17-86 | RRM1_RRT5 |
| cd12674 | 125-183 | RRM1_Nop4p |
| cd12600 | 17-86 | RRM2_SRSF4_like |
| cd12583 | 17-64 | RRM2_hnRNPD |
| cd12557 | 17-88 | RRM3_RBM15 |
| cd12582 | 17-87 | RRM2_hnRNPA3 |
| cd12377 | 18-88 | RRM3_Hu |
| cd12291 | 18-87 | RRM1_La |
| cd12385 | 17-86 | RRM1_hnRNPM_like |
| cd12281 | 123-181 | RRM1_TatSF1_like |
| cd12260 | 18-64 | RRM2_SREK1 |
| cd12580 | 17-86 | RRM2_hnRNPA1 |
| cd12361 | 17-71 | RRM1_2_CELF1-6_like |
| cd12268 | 18-71 | RRM_Vip1 |
| cd12619 | 18-86 | RRM2_PUB1 |
| cd12579 | 17-71 | RRM2_hnRNPA0 |
| cd12295 | 17-87 | RRM_YRA2 |
| cd12651 | 18-71 | RRM2_SXL |
| cd12317 | 18-70 | RRM4_RBM19_RRM3_MRD1 |
| cd12565 | 122-183 | RRM1_MRD1 |
| cd12308 | 15-70 | RRM1_Spen |
| cd12698 | 16-88 | RRM3_PTBPH3 |
| cd12397 | 18-89 | RRM2_Nop13p_fungi |
| cd12296 | 123-194 | RRM1_Prp24 |
| cd12638 | Sep-88 | RRM3_CELF1_2 |
| cd12404 | 15-88 | RRM2_NCL |
| cd12558 | 17-88 | RRM3_RBM15B |
| smart00360 | 17-86 | RRM |
| smart00360 | 122-184 | RRM |
| COG0724 | Aug-88 | RRM |
| pfam14259 | 18-85 | RRM_6 |
| TIGR01645 | 16-172 | half-pint |
| pfam14259 | 123-183 | RRM_6 |
| TIGR01645 | 17-86 | half-pint |
| TIGR01642 | 17-88 | U2AF_lg |
| TIGR01628 | 18-81 | PABP-1234 |
| TIGR01628 | 18-190 | PABP-1234 |
| TIGR01622 | Jul-86 | SF-CC1 |
| TIGR01659 | Oct-71 | sex-lethal |
| TIGR01642 | 17-89 | U2AF_lg |
| TIGR01661 | 20-193 | ELAV_HUD_SF |
Ontology Information
| HPRD ID | 488 |
|---|---|
| Molecular Class | RNA binding protein |
| Molecular Function | Oxidoreductase activity (GO:0016491) |
| Biological Process | Hormone metabolism (GO:0042445) |
Drug Information
No matching records could be found.