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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
SRSF6 6431 serine/arginine-rich splicing factor 6  20SRP55, B52 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
23132731   2013Cell line : RKO, SNC19 ST14,RKO ST14 1

Source : -

Sample Type : -

No. of Sample : -

Stage : -

-Up-regulation--


Gene Details



NC_000020.10 (42086504..42092245)

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Gene Type protein coding
Gene Family Serine/arginine-rich splicing factors, "RNA binding motif (RRM) containing"
Description The protein encoded by this gene is involved in mRNA splicing and may play a role in the determination of alternative splicing. The encoded nuclear protein belongs to the splicing factor SR family and has been shown to bind with and modulate another member of the family, SFRS12. Alternative splicing results in multiple transcript variants. In addition, two pseudogenes, one on chromosome 17 and the other on the X chromosome, have been found for this gene.[provided by RefSeq, Sep 2010]  
Chromosome 20
Location 20q12-q13.
Start 42086504  
End 42092245  
Strand +  
Gene Sequence

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Length 5742  
OMIM ID 601944   
HGNC ID HGNC:10788   
Unigene ID Hs.684950   
Ensembl ID ENSG00000124193   
PharmGKB ID PA35704   

mRNA Information


mRNA ID ?NM_006275.5
Exon join(1..277,498..646,1908..2032,2170..2378,2652..2735, 2840..5742)  
mRNA Sequence

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Length 3755  



CDS Information


   
Location 171..1205
CDS Sequence

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CCDS ID CCDS13318.1



Protein Information


      
Protein IDNP_006266.2
Protein Nameserine/arginine-rich splicing factor 6
Molecular Wt. (Da)59773
Protein Sequence

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Length 344  
Uniprot IDO95067
Ensembl Protein ID ENSP00000288207  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation301
SPhosphorylation314
SPhosphorylation316
SPhosphorylation301;-
SPhosphorylation303;-
SPhosphorylation45;-
SPhosphorylation297;-
SPhosphorylation299;-
SPhosphorylation259;-
SPhosphorylation118;-
SPhosphorylation119;-
SPhosphorylation324;-
SPhosphorylation326;-
KAcetylation101
SPhosphorylation257
SPhosphorylation261
SPhosphorylation263
SPhosphorylation265
SPhosphorylation295
TPhosphorylation323
SPhosphorylation81

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

No matching records from HPRD source could be found.

Pathway Information


            
Pathway Name Pathway ID
Herpes simplex infection hsa05168
Spliceosome hsa03040


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd12600110-181  RRM2_SRSF4_like
cl17169110-181  RRM_SF superfamily
cd12596Mar-72  RRM1_SRSF6
cl17169Mar-72  RRM_SF superfamily
cd12766110-182  RRM2_SRSF6
cd12337Mar-72  RRM1_SRSF4_like
cd12764110-181  RRM2_SRSF4
cd12594Mar-76  RRM1_SRSF4
cd12765107-180  RRM2_SRSF5
cd12339110-180  RRM2_SRSF1_4_like
cd12595Mar-71  RRM1_SRSF5
cd12373Mar-72  RRM_SRSF3_like
cd00590Apr-68  RRM_SF
cd12602110-170  RRM2_SF2_plant_like
cd12601110-170  RRM2_SRSF1_like
cd12338Mar-68  RRM1_SRSF1_like
pfam00076Apr-65  RRM_1
cd12382Apr-71  RRM_RBMX_like
cd12768110-170  RRM2_SRSF9
cd12599Mar-68  RRM1_SF2_plant_like
cd12597Mar-71  RRM1_SRSF1
cd00590112-178  RRM_SF
pfam00076112-177  RRM_1
cd12399Mar-71  RRM_HP0827_like
cd1223314-71  RRM_Srp1p_AtRSp31_like
cd12341Mar-65  RRM_hnRNPC_like
cd12598Mar-68  RRM1_SRSF9
cd12645Mar-75  RRM_SRSF3
cd12343Mar-68  RRM1_2_CoAA_like
cd12449Mar-70  RRM_CIRBP_RBM3
cd12646Mar-75  RRM_SRSF7
cd12234Apr-64  RRM1_AtRSp31_like
cd12365Apr-68  RRM_RNPS1
cd12387112-176  RRM3_hnRNPM_like
cd12606Mar-68  RRM1_RBM4
cd12342Mar-68  RRM_Nab3p
cd12312Apr-75  RRM_SRSF10_SRSF12
cd12767111-170  RRM2_SRSF1
cd12609Mar-68  RRM2_CoAA
cd12398Apr-70  RRM_CSTF2_RNA15_like
cd12411Apr-71  RRM_ist3_like
cd12354Apr-65  RRM3_TIA1_like
cd12454Apr-68  RRM2_RIM4_like
cd12371Feb-67  RRM2_PUF60
cd12236May-75  RRM_snRNP70
cd12385111-181  RRM1_hnRNPM_like
cd12414Mar-70  RRM2_RBM28_like
cd12608Mar-70  RRM1_CoAA
cd12284May-62  RRM2_RBM23_RBM39
cd12407Mar-70  RRM_FOX1_like
cd12347Apr-66  RRM_PPIE
cd12447Mar-70  RRM1_gar2
cd12658111-181  RRM1_MYEF2
cd12298Apr-68  RRM3_Prp24
cd12657111-181  RRM1_hnRNPM
cd12604Mar-74  RRM_RALY
cd12355Mar-71  RRM_RBM18
cd12399111-183  RRM_HP0827_like
cd12559Apr-75  RRM_SRSF10
cd12346Apr-65  RRM3_NGR1_NAM8_like
cd12358May-70  RRM1_VICKZ
cd12560Apr-75  RRM_SRSF12
cd1232414-73  RRM_RBM8
cd12379Apr-69  RRM2_I_PABPs
cd12412Mar-60  RRM_DAZL_BOULE
cd12418Feb-69  RRM_Aly_REF_like
cd12380Apr-70  RRM3_I_PABPs
cd12273Mar-68  RRM1_NEFsp
cd12625Jan-70  RRM1_IGF2BP1
cd12254Apr-66  RRM_hnRNPH_ESRPs_RBM12_like
cd12272Mar-67  RRM2_PHIP1
cd12619Apr-66  RRM2_PUB1
cd12494Apr-65  RRM3_hnRNPR
cd12340Mar-67  RBD_RRM1_NPL3
cd12237Apr-75  RRM_snRNP35
cd12448Apr-65  RRM2_gar2
cd12450Mar-71  RRM1_NUCLs
cd12335Apr-71  RRM2_SF3B4
cd12323Mar-65  RRM2_MSI
cd12552Apr-67  RRM_Nop15p
cd12309May-58  RRM2_Spen
cd12352Apr-67  RRM1_TIA1_like
cd12566Mar-58  RRM2_MRD1
cd12251Apr-71  RRM3_hnRNPR_like
cd12661111-182  RRM3_hnRNPM
cd12570Mar-70  RRM5_MRD1
cd12283Apr-67  RRM1_RBM39_like
cd12466Nov-70  RRM2_AtRSp31_like
cd12223Apr-67  RRM_SR140
cd12316Mar-62  RRM3_RBM19_RRM2_MRD1
cd12284112-178  RRM2_RBM23_RBM39
cd12627Jan-75  RRM1_IGF2BP3
cd12607Mar-68  RRM2_RBM4
cd12467Apr-71  RRM_Srp1p_like
cd12307Apr-68  RRM_NIFK_like
cd12605Mar-63  RRM_RALYL
pfam1389318-70  RRM_5
cd12353Apr-65  RRM2_TIA1_like
cd12276Dec-68  RRM2_MEI2_EAR1_like
cd12673Mar-56  RRM_BOULE
cd12662111-182  RRM3_MYEF2
cd12603Mar-63  RRM_hnRNPC
cd12626Jan-70  RRM1_IGF2BP2
cd12375Sep-70  RRM1_Hu_like
cd12495Apr-71  RRM3_hnRNPQ
cd12370Feb-67  RRM1_PUF60
cd12616Apr-77  RRM1_TIAR
cd12361Mar-61  RRM1_2_CELF1-6_like
cd12311Sep-67  RRM_SRSF2_SRSF8
cd12414111-176  RRM2_RBM28_like
cd12405112-178  RRM3_NCL
cd12671Apr-70  RRM_CSTF2_CSTF2T
cd12393Apr-65  RRM_ZCRB1
cd12327Feb-70  RRM2_DAZAP1
cd12318Apr-67  RRM5_RBM19_like
cd12231Mar-70  RRM2_U2AF65
cd12773Apr-73  RRM2_HuR
cd12392Mar-66  RRM2_SART3
cd12363Sep-70  RRM_TRA2
cd1236916-67  RRM4_RBM45
cd12413Apr-71  RRM1_RBM28_like
cd12775Apr-75  RRM2_HuB
cd12618Apr-65  RRM2_TIA1
cd12391Apr-51  RRM1_SART3
cd12404112-176  RRM2_NCL
cd12565111-172  RRM1_MRD1
cd12227Apr-73  RRM_SCAF4_SCAF8
cd12400Apr-68  RRM_Nop6
cd12614Apr-60  RRM1_PUB1
cd12330Mar-70  RRM2_Hrp1p
cd12397Apr-70  RRM2_Nop13p_fungi
cd12579Mar-70  RRM2_hnRNPA0
cd12674112-184  RRM1_Nop4p
cd12650Sep-70  RRM1_Hu
cd12384Mar-56  RRM_RBM24_RBM38_like
cd12320Sep-70  RRM6_RBM19_RRM5_MRD1
cd12298112-176  RRM3_Prp24
cd12322Mar-71  RRM2_TDP43
cd12567Mar-57  RRM3_RBM19
cd12417Apr-68  RRM_SAFB_like
cd12325May-59  RRM1_hnRNPA_hnRNPD_like
cd12617Apr-65  RRM2_TIAR
cd12776Apr-70  RRM2_HuC
cd12243Feb-58  RRM1_MSSP
cd12409Mar-66  RRM1_RRT5
cd12378May-56  RRM1_I_PABPs
cd1252718-68  RRM2_EAR1_like
cd12350May-65  RRM3_SHARP
cd12332Mar-62  RRM1_p54nrb_like
cd12326Mar-52  RRM1_hnRNPA0
cd12402May-70  RRM_eIF4B
cd12351Apr-67  RRM4_SHARP
cd12529Sep-68  RRM2_MEI2_like
cd12226Mar-43  RRM_NOL8
cd12774Apr-62  RRM2_HuD
cd12328Mar-52  RRM2_hnRNPA_like
cd12344May-58  RRM1_SECp43_like
cd1277236-71  RRM1_HuC
cd12305Nov-71  RRM_NELFE
cd12555Apr-60  RRM2_RBM15
cd12615Apr-70  RRM1_TIA1
cd12260107-179  RRM2_SREK1
cd12382112-177  RRM_RBMX_like
cd12343111-177  RRM1_2_CoAA_like
cd12756Apr-58  RRM1_hnRNPD
cd12386Apr-67  RRM2_hnRNPM_like
cd12306Apr-67  RRM_II_PABPs
cd12621Apr-65  RRM3_TIA1
cd12334Apr-62  RRM1_SF3B4
cd12448112-178  RRM2_gar2
cd1236215-68  RRM3_CELF1-6
cd1261036-62  RRM1_SECp43
cd12770Jun-71  RRM1_HuD
cd12564111-178  RRM1_RBM19
cd12641Sep-70  RRM_TRA2B
cd1233935-68  RRM2_SRSF1_4_like
cd12240Apr-66  RRM_NCBP2
cd12290Apr-56  RRM1_LARP7
cd12242Mar-48  RRM_SLIRP
cd12418111-178  RRM_Aly_REF_like
cd12541112-180  RRM2_La
cd12447111-178  RRM1_gar2
cd12450111-178  RRM1_NUCLs
cd1264936-71  RRM1_SXL
cd12248Apr-67  RRM_RBM44
cd12387Apr-66  RRM3_hnRNPM_like
cd12229Apr-45  RRM_G3BP
cd12463Mar-45  RRM_G3BP1
cd12245May-60  RRM_scw1_like
cd1277136-71  RRM1_HuB
cd12675Feb-70  RRM2_Nop4p
cd12385Mar-67  RRM1_hnRNPM_like
cd12620Apr-65  RRM3_TIAR
cd12223112-178  RRM_SR140
cd12588Mar-67  RRM1_p54nrb
cd12271Apr-68  RRM1_PHIP1
cd12485Apr-60  RRM1_RBM47
cd12613Apr-66  RRM2_NGR1_NAM8_like
cd12574Mar-44  RRM1_DAZAP1
cd12350112-178  RRM3_SHARP
cd12575Apr-58  RRM1_hnRNPD_like
cd12609110-176  RRM2_CoAA
cd12758Mar-71  RRM1_hnRPDL
cd12345Apr-66  RRM2_SECp43_like
cd12408Sep-57  RRM_eIF3G_like
cd12674Apr-70  RRM1_Nop4p
cd1227836-60  RRM_eIF3B
cd1261236-66  RRM2_SECp43
pfam08777112-166  RRM_3
cd12642Sep-70  RRM_TRA2A
cd12524May-62  RRM1_MEI2_like
cd12249Apr-60  RRM1_hnRNPR_like
cd12769Jun-71  RRM1_HuR
cd12622Apr-57  RRM3_PUB1
cd12378112-178  RRM1_I_PABPs
cd12383Mar-58  RRM_RBM42
cd12578Mar-66  RRM1_hnRNPA_like
cd12415Apr-70  RRM3_RBM28_like
smart00360Mar-67  RRM
smart00360111-178  RRM
TIGR016284-173  PABP-1234
pfam14259112-177  RRM_6
COG0724Mar-77  RRM
pfam14259Apr-65  RRM_6
TIGR016284-174  PABP-1234
TIGR01622Mar-70  SF-CC1
TIGR016224-178  SF-CC1
TIGR01645Jan-67  half-pint
TIGR01642Mar-70  U2AF_lg
PLN03134Mar-70  PLN03134
COG072430-177  RRM
TIGR01661Apr-73  ELAV_HUD_SF
TIGR01645Mar-73  half-pint
TIGR01648Apr-76  hnRNP-R-Q
TIGR01628Feb-76  PABP-1234
TIGR01661Jun-71  ELAV_HUD_SF


Ontology Information


   
HPRD ID8496
Molecular ClassSerine/threonine kinase
Molecular FunctionMolecular function unknown (GO:0005554)
Biological ProcessBiological_process unknown (GO:0000004)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO