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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| SHBG | 6462 | sex hormone-binding globulin | 17 | ABP, TEBG, MGC126834, MGC138391 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 21317201 | 2011 | Cell line : - Source : Population-based DACHS study (South Germany) Sample Type : Population based case control study No. of Sample : 1798 CRC cases and 1810 controls Stage : - | Genotyping | Polymorhpism | - | Role of ESR2 in the risk for developing CRC in women and suggest that HSD17B1, ABCB1, and SHBG genes may contribute to sex steroid-mediated effects on CRC development. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes a steroid binding protein that was first described as a plasma protein secreted by the liver but is now thought to participate in the regulation of steroid responses. The encoded protein transports androgens and estrogens in the blood, binding each steroid molecule as a dimer formed from identical or nearly identical monomers. Polymorphisms in this gene have been associated with polycystic ovary syndrome and type 2 diabetes mellitus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014] |
| Chromosome | 17 |
| Location | 17p13.1 |
| Start | 7517382 |
| End | 7536700 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 19319 |
| OMIM ID | 182205 |
| HGNC ID | HGNC:10839 |
| Unigene ID | Hs.632235 |
| Ensembl ID | ENSG00000129214 |
| PharmGKB ID | PA35745 |
mRNA Information
| mRNA ID | ?NM_001040.4 |
|---|---|
| Exon | complement(389..834) | mRNA Sequence | Download Select all |
| Length | 3016 |
Protein Information
| Protein ID | NP_001031.2 |
|---|---|
| Protein Name | sex hormone-binding globulin |
| Molecular Wt. (Da) | 22521 |
| Protein Sequence | Download Select all |
| Length | 402 |
| Uniprot ID | O94817 |
| Ensembl Protein ID | ENSP00000425164 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| Y | Phosphorylation | 86;- |
| N | Glycosylation | 380 |
| N | Glycosylation | 396 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 6652 | SORD | 1679 | NP_003095.2 | yeast 2-hybrid | 15862967 |
| 6717 | SRI | 1680 | NP_003121.1 | yeast 2-hybrid | 15862967 |
| 7337 | UBE3A | 3375 | NP_000453.2 | yeast 2-hybrid | 15862967 |
| 23557 | SNAPIN | 6111 | NP_036569.1 | yeast 2-hybrid | 15862967 |
| 54020 | SLC37A1 | 10479 | NP_061837.3 | yeast 2-hybrid | 15862967 |
| 80149 | ZC3H12A | 8021 | NP_079355.2 | yeast 2-hybrid | 15862967 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00110 | 67-196 | LamG |
| cl22861 | 67-196 | LamG superfamily |
| pfam00054 | 75-205 | Laminin_G_1 |
| smart00282 | 72-202 | LamG |
| pfam02210 | 75-196 | Laminin_G_2 |
| PRK00364 | 118-155 | groES |
| cl09113 | 118-155 | cpn10 superfamily |
| pfam06439 | 84-159 | DUF1080 |
| COG0234 | 118-154 | GroES |
Ontology Information
| HPRD ID | 5775 |
|---|---|
| Molecular Class | Transport/cargo protein |
| Molecular Function | Receptor binding (GO:0005102) |
| Biological Process | Apoptosis (GO:0006915); Regulation of cell growth (GO:0001558) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P04278 | DB00624 | Testosterone | SmallMoleculeDrug |
| P04278 | DB00648 | Mitotane | SmallMoleculeDrug |
| P04278 | DB00717 | Norethindrone | SmallMoleculeDrug |
| P04278 | DB00741 | Hydrocortisone | SmallMoleculeDrug |
| P04278 | DB00783 | Estradiol | SmallMoleculeDrug |
| P04278 | DB00858 | Drostanolone | SmallMoleculeDrug |
| P04278 | DB01185 | Fluoxymesterone | SmallMoleculeDrug |
| P04278 | DB01406 | Danazol | SmallMoleculeDrug |
| P04278 | DB04574 | Estropipate | SmallMoleculeDrug |
| P04278 | DB05275 | transdermal testosterone gel | SmallMoleculeDrug |
| P04278 | DB06412 | Oxymetholone | SmallMoleculeDrug |
| P04278 | DB06710 | Methyltestosterone | SmallMoleculeDrug |
| P04278 | DB00421 | Spironolactone | SmallMoleculeDrug |