Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| NUCKS1 | 64710 | Nuclear casein kinase and cyclin-dependent kinase substrate 1 | 1 | JC7; NUCKS |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23065711 | 2013 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | - | Up-regulation | - | The overexpression of NUCKS1 in cancer cells could be used as a CRC prognostic marker and might also be a target for treatment of this disease. |
| 22968445 | 2012 | Cell line : - Source : Department of Pathology of Wrocaw Medical University. Sample Type : CRC tumor and normal tissue No. of Sample : 8 Stage : - | Laser capture microdissection,FFPE-FASP,SAX fractionation,LC-MSMS,Label-free quantitation. | Up-regulation | - | A list of genes including this gene are differentially expressed analysed by LC-MS/MS technique. To compare the proteomes of colonic mucosa (normal or N) and colon cancer (cancer or C), we analyzed archival FFPE clinical samples originating from eight patients. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes a nuclear protein that is highly conserved in vertebrates. The conserved regions of the protein contain several consensus phosphorylation sites for casein kinase II and cyclin-dependent kinases, two putative nuclear localization signals, and a basic DNA-binding domain. It is phosphorylated in vivo by Cdk1 during mitosis of the cell cycle. [provided by RefSeq, Aug 2010] |
| Chromosome | 1 |
| Location | 1q32.1 |
| Start | 205712819 |
| End | 205750244 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 37426 |
| OMIM ID | 611912 |
| HGNC ID | HGNC:29923 |
| Unigene ID | Hs.213061 |
| Ensembl ID | ENSG00000069275 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_022731.4 |
|---|---|
| Exon | join(1..288,20624..20673,22440..22545,26264..26319, 29592..29744,30569..30718,31766..37426) | mRNA Sequence | Download Select all |
| Length | 6471 |
CDS Information
| Location | join(272..288,20624..20673,22440..22545,26264..26319, 29592..29744,30572..30718,31766..31965) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | - |
Protein Information
| Protein ID | NP_073568.2 |
|---|---|
| Protein Name | Nuclear casein kinase and cyclin-dependent kinase substrate 1 |
| Molecular Wt. (Da) | 27165 |
| Protein Sequence | Download Select all |
| Length | 243 |
| Uniprot ID | Q99958 |
| Ensembl Protein ID | ENSP00000326371 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 113 |
| S | Phosphorylation | 144 |
| S | Phosphorylation | 19 |
| T | Phosphorylation | 179 |
| S | Phosphorylation | 181 |
| S | Phosphorylation | 58 |
| S | Phosphorylation | 204 |
| S | Phosphorylation | 214 |
| S | Phosphorylation | 223 |
| S | Phosphorylation | 229 |
| S | Phosphorylation | 181;- |
| S | Phosphorylation | 214;- |
| T | Phosphorylation | 179;- |
| S | Phosphorylation | 14;- |
| S | Phosphorylation | 75;- |
| S | Phosphorylation | 79;- |
| S | Phosphorylation | 73;- |
| T | Phosphorylation | 177;- |
| S | Phosphorylation | 130;- |
| S | Phosphorylation | 132;- |
| T | Phosphorylation | 202;- |
| T | Phosphorylation | 220;- |
| S | Phosphorylation | 221;- |
| S | Phosphorylation | 240;- |
| S | Phosphorylation | 234;- |
| S | Phosphorylation | 40;- |
| S | Phosphorylation | 54;- |
| S | Phosphorylation | 61;- |
| Y | Phosphorylation | 26 |
| S | Phosphorylation | 30 |
| S | Phosphorylation | 149 |
| S | Phosphorylation | 97 |
| S | Phosphorylation | 101 |
| T | Phosphorylation | 68 |
| T | Phosphorylation | 222 |
| Y | Phosphorylation | 146 |
| S | Acetylation | 2 |
| K | Acetylation | 9 |
| T | Phosphorylation | 34 |
| K | Acetylation | 52 |
| K | Acetylation | 175 |
| K | Acetylation | 184 |
| K | Acetylation | 188 |
| K | Acetylation | 196 |
| S | Phosphorylation | 2 |
| S | Phosphorylation | 39 |
| Y | Phosphorylation | 13 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
No matching records could be found.
Ontology Information
| HPRD ID | 4061 |
|---|---|
| Molecular Class | DNA binding protein |
| Molecular Function | Transcription factor activity (GO:0003700) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.